PROLAKTİNOMADA KABERGOLİN VE KALP KAPAK BOZUKLUKLARI
Kabergolin ergot türevi dopamin agonisti olup hormon hipersekresyonu olan hipofiz tümörlerinde yaygın olarak kullanılmaktadır. Parkinson hastalığında kabergolin kullanımı, klinik olarak anlamlı kardiak kapak hastalığı gelişimi riski ile ilişkili iken prolaktinoma ve akromegalide kabergolin tedavisi anlamlı valvulopati risk artışı ile ilişkili bulunmamıştır. Ayrıca prolaktinomalarda valvuler anormallik ile kabergolin kullanım süresi veya kümülatif dozu arasında korelasyon gösterilmemiştir. Uzun dönem yüksek doz (>3 mg/hafta), kabergolin tedavisi alan hastalarda valvüler anormallikleri göstermek için ekokardiografi ihtiyacı varken, 1-2 mg/hafta dozunda kabergolin tedavisinde düzenli ekokardiografi ile tarama gerekmez.
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