Kenan ÇADIRCI, İsra OĞUZ, Tuba USTA, Havva KESKİN, Ayşe ÇARLIOĞLU, Şenay ARIKAN

Erkek İdiopatik Hipogonadotropik Hipogonadizmli Hastalarda Monosit/ HDL oranı

Amaç: Önceki çalışmalar, düşük testosteron düzeylerine sahip idiopatik hipogonadotropik hipogonadizm (İHH) hastalarında bozulmuş glukoz metabolizmasına ve artmış kardiyovasküler riske yatkınlık olduğunu göstermiştir. Monosit/yüksek yoğunluklu lipoprotein kolesterol (HDL-C) oranı (MHR) de inflamasyon ve kardiyovasküler risk göstergesi olarak gösterilmiştir. Bu çalışmanın amacı, İHH tanılı erkek hastalarda MHR'yi araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya daha önce tedavi almamış İHH tanısı olan 31 erkek hasta ve sağlıklı 44 erkek hasta dahil edildi. Tüm katılımcıların kan örneklemesi, antropometrik ölçümleri ve fizik muayeneleri yapıldı. Bulgular: İHH hastalarının yaş ortalaması 22,5±7,2 yıl ve sağlıklı kontrollerin yaş ortalaması ise 22,9±6,4 yıl idi. Hastalar ve kontroller arasında ortalama HDL-kolesterol, ortalama monosit sayısı ve ortalama MHR açısından istatistiksel olarak anlamlı bir fark yoktu. MHR ayrıca diğer hematolojik parametreler, enflamatuar parametreler ve toplam testosteron seviyesi ile korele değildi. Sonuçlar: Önceki çalışmalarda MHR'nin kardiyovasküler riskin bir göstergesi olduğu gösterilmiştir, ancak bu çalışmada İHH hastalarında artmış bir MHR değeri tespit edemedik.

Anahtar Kelimeler:

Monosit, HDL kolesterol, inflamasyon, idiopatik hipogonadotropik hipogonadizm

Monocyte to HDL-Cholesterol Ratio in Male with Hypogonadotropic Hypogonadism

Purpose: Previous studies have shown that idiopatic hypogonadotropic hypogonadism (IHH) patients with low testosterone levels lead to an impaired glucose metabolism, and an increased cardiovascular risk. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) also has been shown to be an indicator of inflammation and cardiovascular risk. The purpose of the present study is to investigate MHR in the male with IHH. Material and Methods: This study includes 31 men with IHH without previous treatment for the disease and 44 healthy men. The blood sampling, anthropometric measures, and physical examination were undertaken by all the participants. Results: Mean ages of the IHH patients and the healty controls were 22.5±7.2 years vs. 22.9±6.4 years. There was no statistically significant difference between the patients and controls in terms of the mean HDL-C, mean monocyte count, and mean MHR. The MHR also was not correlated with the other hematological parameters, inflammatory parameters, and the total testosterone level. Conclusion: MHR has been shown to be an indicator of cardiovascular risk in previous studies but we could not detect an increased MHR value in patients with IHH In this study.

Keywords:

Monocyte, HDL-cholesterol, inflammation, Idiopathic hypogonadotropic hypogonadism,

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