Sezgin GÜNEŞ, Sercan ERGÜN, Gülgez Neslihan TAŞKURT HEKİM

Ferroptoz ve erkek infertilitesi

Ferroptoz, demire bağlı lipid peroksit birikimi ile karakterize, apoptotik olmayan düzenlenmiş hücre ölümünün yeni tanımlanmış bir şeklidir. Bilinen hücre ölümü tiplerinden morfolojik ve biyokimyasal olarak fark- lıdır. Erkek infertilitesinin birçok nedeni olabilir. Her ne kadar apoptotik hücre ölüm mekanizmasıyla erkek infertilitesi pek çok farklı açıdan iliş- kilendirilmiş olsa da, ferroptoz ile infertilite ilişkisi çok güncel bir konu olup üzerine henüz az sayıda çalışma yapılmıştır. Yapılan çalışmalar, ferroptoz mekanizmasının daha da aydınlatılmasıyla erkek infertilitesin- deki bilinmeyenler daha iyi çözümlenebileceğini ortaya koymuştur. Bu derlemede ferroptozun ilk tanımlandığı günden günümüze kadarki fer- roptoz ile erkek infertilitesini ilişkilendiren tüm bulgular değerlendirildi.

Ferroptosis and male infertility

Ferroptosis is a newly defined form of non-apoptotic regulated cell death characterized by iron-dependent accumulation of lipid peroxide. It differs morphologically and biochemically from known cell death types. Male infertility can have many causes. Although the mechanism of apoptotic cell death and male infertility has been associated with many different aspects, the association between ferroptosis and male infertility is a very up-to-date issue and few studies have been conducted on it yet. Studies have revealed that the unknowns in male infertility can be better resolved by further elucidating the ferroptosis mechanism. In this review, all findings related to male infertility and ferroptosis since the first definition of ferroptosis were evaluated.

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