Safiye Bahar ÖLMEZ, Adnan ÖZÇETİN, Ahmet ATAOĞLU

Paroxetine induced reversible dyskinesia: a case report

Seçici serotonin geri alım inhibitörleri (SSGİ) son yıllarda psikiyatrik bozuklukların tedavisinde sıklıkla kullanılan ilaçlardır. Paroksetin SSGİ grubunda yer alan ilaçlardan biridir. Literatürde paroksetin ilişkili diskinezi olguları diğer hareket bozukluklarına göre oldukça nadir olup sunulan olgular yüz diskinezilerini içermektedir. Bu yazıda klorpromazin tedavisine paroksetin eklenmesi sonucunda ekstiremitelerinde koreiform diskineziler ortaya çıkan bir olgu sunulacaktır. Araştırdığımız kadarıyla, olgumuz paroksetin ile ilişkili ekstiremite diskinezisi gözlenen ilk olgu özelliği taşımaktadır.

Paroksetin kullanımı ile ilişkili geri dönüşümlü diskinezi olgusu

Selective serotonin reuptake inhibitors (SSRI) are the primary medications that have been used recently for the treatment of psychiatric disorders. Paroxetine is one of the medications in the category of SSRI. In the literature, dyskinesia cases related to paroxetine are quite rare in comparison to other movement disorders, and the ones that have been presented are facial dyskinesia. The purpose of this report is to present an involuntary choreiform dyskinesia case that appears in the extremities related to addition of paroxetine on chlorpromazine. To our knowledge, our case, extremity dyskinesia related to paroxetine is the first case that has been observed so far.

PDF

___

1. Stahl SM. Stahl's Essential Psychopharmacology. Neuroscientific Basis and Practical Applications: Serotonin-Specific Reuptake Inhibitors. New York: Cambridge University Press, 2013, p.575- 590.
2. Arnone D, Hansen L, Kerr JS. Acute dystonic reaction in an elderly patient with mood disorder after titration of paroxetine: possible mechanisms and implications for clinical care. J Psychopharmacol (Oxf) 2002; 16:395-397.
3. Coulter DM, Pillans PI. Fluoxetine and extrapyramidal side effects. Am J Psychiatry 1995; 152:122-125.
4. Madhusoodanan S, Alexeenko L, Sanders R, Brenner R. Extrapyramidal symptoms associated with antidepressants. A review of the literature and an analysis of spontaneous reports. Ann Clin Psychiatry 2010; 22:148-156.
5. Carluer L, Schupp C, Defer GL. Ear dyskinesia. J Neurol Nerosurg Psychiatry 2006; 77:802-803.
6. Lee MS, Nam JW. A case of paroxetine induced dyskinetic movements. J Clin Psychopharmacol 2000; 20:712-713.
7. Botsaris SD, Sypek JM. Paroxetine and tardive dyskinesia. J Clin Psychopharmacol 1996; 16:258-259.
8. Boffa E, Lofchy J. Paroxetine and tardive akathisia. Can J Psychiatry 2000; 45:398.
9. Hawthorne JM, Caley CF. Extrapyramidal reactions associated with serotonergic antidepressants. Ann Pharmacotherapy 2015; 9:1136-1152.
10. Schillevoort I, Van Puijenbroek EP, De Boer A, Roos RAC, Jansen PA, Leufkens HGM. Extrapyramidal syndromes associated with aelective serotonin reuptake inhibitors: a case-control study using spontaneous reports. Int Clin Psychopharmacol 2002; 17:75-79.
11. Birthi P, Walters C, Karandikar N. A rare case of tardive dyskinesia and akathisia induced by citalopram. PM R 2010; 2:973-975.
12. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth ed., (DSM-5), Arlington, VA: American Psychiatric Publishing, 2013.
13. Bobillier P, Seguin S, Petitjean F, Salvert D, Touret M, Jouvet M. The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography. Brain Res 1976; 113:449-486.
14. Taylor JB, Cunningham MC, Benes FM. Neonatal raphe lesions increase dopamine fibers in prefrontal cortex of adult rats. Neuroreport 1998; 9:1811-1815.
15. Hedenmalm K, Güzey C, Dahl ML, Yue QY, Spigset O. Risk factors for extrapyramidal symptoms during treatment with selective serotonin reuptake inhibitors, including cytochrome P-450 enzyme, and serotonin and dopamine transporter and receptor polymorphisms. J Clin Psychopharmacol 2006; 26:192-197.