Mahmut Zabit KARA, Mehmet Hamdi ÖRÜM, Ebru SEKMEN

Is there a relationship between basophil, platelet-related parameters and developmental stuttering?

Objective: Studies show that developmental stuttering (DS) may be associated with inflammatory processes.Complete blood count (CBC) values have been used as indicators of a systemic inflammatory response. We aimedto evaluate the relationship between CBC values particularly basophil, platelet, and lymphocyte-related parameters and DS. Method: In this retrospective case-control study, the CBC values of 54 patients who were diagnosed with DS were compared with the data of 54 healthy subjects. Results: Basophil count, percentage of basophil, and platelet count were significantly higher (p=0.001, r=0.35; p=0.044, r=0.19; p=0.045, r=0.11; respectively); mean platelet volume was significantly lower in the patient group (p=0.000, r=-0.54). The areas under the ROC curve of basophil count, percentage of basophil, and platelet count for patient group were 0.708, 0.611, and 0.636. A significant correlation was found between basophil count and platelet count (r=0.276, p=0.048), basophil count and mean platelet volume (r=-0.420, p=0.002), basophil count and percentage of basophil (r=0.685, p=0.000). Basophil count correlated with disease duration (r=-0.296, p=0.035). According to the Binary logistic regression analysis, low mean platelet volume predicts DS. Discussion: Inflammation might play a role in the etiopathogenesis of DS. Basophil and platelet-related parameters may be potential markers for DS. (Anatolian Journal of Psychiatry 2020; 21(2):187-194)

Bazofil ve trombosit ile ilgili parametreler ile gelişimsel kekemelik arasında bir ilişki var mı?

Amaç: Çalışmalar gelişimsel kekemeliğin (GK) inflamatuar süreçlerle ilişkili olabileceğini göstermektedir. Tam kan sayımı (TKS) değerleri sistemik inflamatuar yanıtın göstergesi olarak kullanılmaktadır. Amacımız, özellikle bazofil, trombosit ve lenfositle ilişkili parametreler olmak üzere TKS ile GK arasındaki ilişkiyi değerlendirmektir. Yöntem: Bu geriye dönük olgu-kontrol çalışmasında, GK tanısı konmuş 54 hastanın TKS değerleri, 54 sağlıklı bireyin verileriyle karşılaştırıldı. Bulgular: Hasta grubunda, bazofil sayısı, bazofil yüzdesi ve trombosit sayısı anlamlı olarak daha yüksekti (p=0.001, r=0.35; p=0.044, r=0.19; p=0.045, r=0.11; sırasıyla) ve ortalama trombosit hacmi anlamlı olarak daha düşüktü (p=0.000, r=-0.54). Hasta grubunun bazofil sayısı, bazofil oranı ve trombosit sayısı düzeylerine ait ROC eğrisi altında kalan alanlar 0.708, 0.611 ve 0.636 idi. Bazofil sayısı ve trombosit sayısı (r=0.276, p=0.048), bazofil sayısı ve ortalama trombosit hacmi (r=-0.420, p=0.002), bazofil sayısı ve bazofil oranı (r=0.685, p=0.000) arasında anlamlı bir ilişki bulundu. Bazofil sayısı ile hastalık süresi arasında korelasyon vardı (r=-0.296, p=0.035). Binary lojistik regresyon analizine göre, düşük ortalama trombosit hacmi GK’yi öngörmektedir. Tartışma: GK’nin etiyopatogenezinde inflamasyon rol oynayabilir. Bazofil ve trombosit ile ilişkili parametreler GK için potansiyel inflamasyon belirteçleri olabilir. (Anadolu Psikiyatri Derg 2020; 21(2):187-194)

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