Mehmet Akif CAMKURT, Mehmet Fatih YILMAZ, Serkan GÜNEŞ

Duloksetine bağlı gelişen spontan ejekülasyon

Sertleşme işlev bozukluğu, uyarılma sorunları, libido azalması veya orgazm gecikmesi gibi cinsel işlev bozuklukları antidepresan tedavinin sık görülen yan etkileri arasında yer almaktadır. Ancak, antidepresanlara bağlı spontan ejakülasyon nadir bir yan etkidir. Bu güne kadar essitalopram, venlafaksin ve reboksetin kullanımına bağlı spontan ejakülasyon olguları bildirilmiştir. Bu yazıda duloksetinle spontan ejakülasyon gelişen 46 yaşındaki bir erkek olgu ele alınacaktır. (Anadolu Psikiyatri dergisi 2016; 17(Ek.3):14-16).

Spontaneous ejaculation induced by duloxetine

Sexual dysfunctions such as diminished libido, erectile dysfunction, arousal problems, or delayed orgasm are common side effects of antidepressant medication. However, spontaneous ejaculation is a rare side effect caused by antidepressants. Several case of spontaneous ejaculation have been reported about escitalopram, venlafaxine and reboxetine in the literature. In this paper, a 46-year-old man who developed spontaneous ejaculation with duloxetine is discussed. (Anatolian Journal of Psychiatry 2016; 17(Suppl.3):14-16).

___

1. Karpa KD, Cavanaugh JE, Lakoski JM. Duloxetine pharmacology: profile of a dual monoamine modulator. CNS Drug Rev 2002; 8(4):361-376.

2. Pergolizzi JV, Raffa RB, Taylor R, Rodriguez G, Nalamachu S, Langley P. A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and low back pain. Pain Pract 2013; 13(3):239-252.

3. Patel DS, Deshpande SS, Patel CG, Singh S. Duloxetine: a dual action antidepressant. Indo Glob J Pharm Sci 2011; 1(1).

4. Wernicke JF, Gahimer J, Yalcin I, WulsterRadcliffe M, Viktrup L. Safety and adverse event profile of duloxetine. Expert Opin Drug Saf 2005; 4(6):987-993.

5. O'Flynn R, Michael A. Reboxetine-induced spontaneous ejaculation. Br J Psychiatry 2000; 177:567-568.

6. Roose SP. Tolerability and patient compliance. J Clin Psychiatry 1999; 60(Suppl.1):14-17; discussion 46-48.

7. Rothschild AJ. Sexual side effects of antidepressants. J Clin Psychiatry 2000; 61(Suppl.1):28-36.

8. Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of PsychotropicRelated Sexual Dysfunction. J Clin Psychiatry 2001; 62(3):10-21.

9. Belli H, Aslaner D, Ural C, Vardar MK, Yesilyurt S, Gul ES. Escitalopram related erectile dysfunction and spontaneous ejaculation during micturition. West Indian Med J 2010; 59(6):715-716.

10. Yanik M. Spontaneous orgasm started with venlafaxine and continued with citalopram. Can J Psychiatry 2004; 49(11):786.

11. Sivrioglu EY, Topaloglu VC, Sarandol A, Akkaya C, Eker SS, Kirli S. Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition. Prog Neuro-Psychopharmacology Biol Psychiatry 2007; 31(2):548- 550.

12. Elliott, Stacy. Ejaculation and orgasm: sexuality in men with SCI. Topics in Spinal Cord Injury Rehabilitation 2002; 1-15.

13. Shores MM, Pascualy M, Lewis NL, Flatness D, Veith RC. Short-term sertraline treatment suppresses sympathetic nervous system activity in healthy human subjects. Psychoneuroendocrinology 2001; 26(4):433-439.

14. Barton DA, Dawood T, Lambert EA, Esler MD, Haikerwal D, Brenchley C, et al. Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk? J Hypertens 2007; 25(10):2117-2124.

15. Licht CMM, Penninx BWJH, de Geus EJC. Response to depression and blood pressure control: All antidepressants are not the same. Hypertension. Am Heart Assoc 2009; 54(1):e2-e2.

16. Oosterhuis I, Heijting L, van Puijenbroek E. Spontaneous ejaculation with the use of noradrenergic reuptake inhibitors. Eur J Clin Pharmacol 2012; 68(10):1461-1462.

17. Sawada N, Uchida H, Suzuki T, Watanabe K, Kikuchi T, Handa T, et al. Persistence and compliance to antidepressant treatment in patients with depression: a chart review. BMC Psychiatry 2009; 9(1):38.