SOLİD ORGAN TRANSPLANTASYONU SONRASI İMMÜNSUPRESİF İLAÇ KULLANIMINA UYUM

Öz ÖZETİlaç kullanımına uyum, reçete edilen ilacın belirlenen süre boyunca, sağlık profesyoneli tarafından önerilen zamana, doza ve sıklığa uygun olarak kullanılmasını ifade etmektedir. Solid organ transplantasyonu yapılan hastaların uzun yıllar çok sayıda ilaç kullanmak durumunda kalmaları ilaç kullanımına uyum konusunda sıkıntı yaşamalarına neden olabilmektedir. İmmünsupresif ilaç kullanımına uyumsuzluk tedavinin başarısını olumsuz yönde etkilemekte, rejeksiyon, greft kaybı ve hatta ölüme kadar varabilen sonuçlara yol açabilmektedir. Solid organ transplantasyonu yapılan hastaların immünsupresif ilaç kullanımına uyumsuzlukları nedeniyle oluşan tıbbi ve ekonomik olumsuzlukların önüne geçebilmek için hastaların immünsupresif kullanımına uyumunun değerlendirilmesi ve bu değerlendirmenin rutin klinik izlemin bir parçası haline getirilmesi gerekmektedir. Hemşirelerin, “ilaç kullanımına uyumu” standart ölçüm araçları ile değerlendirmesi, uyumsuzluk durumunu tespit ederek iyileştirmek üzere girişimlerde bulunması tedavinin başarısı açısından son derece önemlidir. Anahtar Kelimeler: İmmünsupresif; solid organ transplantasyonu; ilaç kullanımına uyum ABSTRACTImmunosuppressive Medication Adherence After Solid Organ TransplantationMedication adherence means that the drug prescribed is used consistently according to the time, dose, and frequency recommended by the health professional during the period determined. The fact that patients who have undergone solid organ transplantation have to use multiple immunosuppressive drugs continuously or for long many years causes them to experience difficulties with medication adherence. Immunosuppressive medication nonadherence negatively affects the success of treatment and may cause rejection, graft loss and death. To prevent medical and financial problems related to immunosuppressive medication nonadherence in solid organ transplant patients, medication adherence should be evaluated and assessing of medication adherence must be a part of routine clinical monitoring. The evaluation of medication adherence using standard measurement methods, determination of nonadherence and having taken a step to improve medication adherence by the nurses are considerably important for the success of treatment.Keywords: Immunosuppressive; solid organ transplantation; medication adherence

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  • Witt CA, Hachem RR. Immunosuppression: What’s Standart and What’s New. Seminars in Respiratory and Critical Care Medicine 2013;34(3):405-13.
  • Williams AF, Manias E, Gaskin CJ, Crawford K. Medicine non-adherence in kidney transplantation. Journal of Renal Care 2014;40(2):107–16.
  • Schaefer HM, Helderman HJ. Current and Emerging Maintenance Immunosuppressive Therapy. Türkiye Klinikleri Nefroloji Özel Dergisi 2012;5(3):1-9.
  • Sandwijk MS, Bemelman FJ, Berg IJM. Immunosuppressive Drugs After Solid Organ Transplantation. Netherlands The Journal of Medicine 2013;71(6):281-89.
  • Schmid-Mohler G, Pechula Thut M, Wuthrich RP, Denhaerynck K, De Geest S. Non-adherence to immunosuppressive medication in renal transplant recipients within the scope of the integrative model of behavioral prediction: a cross-sectional study. Clin Transplant 2010;24: 213–22.
  • Sabate E. Adherence to Long-Term Therapies: Evidence for Action. First edition, Switzerland, World Health Organization, 2003.
  • Russell C, Conn V, Ashbaugh C, Madsen R, Wakefield M, Webb A et al. Taking Immunosuppressive Medicaitons Effectively (TIMELink): A Pilot Randomized Controlled Trial in Adult Kidney Transplant Recipients. Clinical Transplantation 2011; 25(6):864-70.
  • Prihodova L, Nagyova I, Rosenberger J, Majernikova M, Roland R, Groothoff JW et al. Adherence in patients in the first year after kidney transplantation and its impact on graft loss and mortality: a cross-sectional and prospective study. Journal of Advanced Nursing 2014;70(12):2871–83.
  • Prendergast MB, Gaston RS. Optimizing medication adherence: an ongoing opportunity to improve outcomes after kidney transplantation. Clin J Am Soc Nephrol 2010;5:1305-11.
  • Osterberg L, Blashchke T. Adherence to Medication. The New England Journal of Medicine 2005;353:487-97.
  • Oliva M, Singh TP, Gauvreau K, VanderPluym CJ, Bastardi HJ, Almond CS. Impact of medication non-adherence on survival after pediatric heart transplantation in the USA. J Heart Lung Transplant 2013;32:881–8.
  • Morrissey PE, Flynn ML, Lin S. Medication Noncompliance and its Implications in Transplant Recipients. Drugs 2007; 67(10):1463-81.
  • Martínez Pérez AB, López Suárez A, Rodríguez Rodríguez J, Sobrino Márquez JM, Lage Galle E. Medication Adherence in Patients Who Undergo Cardiac Transplantation. Transplantation Proceedings 2013;45:3662-64.
  • MacLaughlin EJ, Raehl CL, Treadway AK, Sterling TL, Zoller DP, Bond CA. Assessing Medication Adherence in The Elderly. Which Tools to Use in Clinical Practice?. Drug Aging 2005;22(3):231-55.
  • Kung M, Koschwanez HE, Painter L, Honeyman V, Broadbent E. Immunosuppressant Nonadherence in Heart, Liver, and Lung Transplant Patients: Associations with Medication Beliefs and Illness Perceptions. Transplantation 2012; 93(9):958-63.
  • Kalogianni A. Can Nursing Interventions increase adherence medication regimen? Health Science Journal 2012;6(1):1-3.
  • Hoy H, Alexander S, Payne J, Zavala E. The Role of Advanced Practice Nurses in Transplant Center Staffing. Progress in Transplantation 2011;21(4):294- 298.
  • Ho PM, Magid DJ, Shetterly SM, Olson KL, Maddox TM, Peterson PN et al. Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease. Am Heart J 2008;155:772–9.
  • Ho PM, Bryson CL, Rumsfeld JS. Medication Adherence Its Importance in Cardiovascular Outcomes. Circulation 2009;119:3028-35.
  • Hartono C, Muthukumar T. Immunsuppressive Drug Therapy. Cold Spring Harbor Perspectives in Medicine 2013;3(9):1-15.
  • Gould E, Mitty E. Medication Adherence is a Partnership, Medication Compliance is Not. Geriatric Nursing 2010;31(4):290-98.
  • Fredericks EM, Magee JC, Opipari-Arrigan L, Shieck V, Well A, Lopez MJ. Adherence and Health-Related Quality of Life in Adolescent Liver Transplant Recipients. Pediatric Transplant 2008;12(3):289-299.
  • Frank-Bader M, Beltran K, Dojlidko D. Improving Transplant Discharge Education Using A Structured Teaching Approach. Progress in Transplantation 2011;21(4):332-39.
  • Eldegez UC, Seyhun Y. Türkiye’ de ve Dünyada Transplantasyonun Tarihçesi. Türkiye Klinikleri Dergisi Genel Cerrahi Özel Dergisi 2013;6(1):1-6.
  • Dobbels F, Lut Berben L, De Geest S, Drent G, Lennerling A, Whittaker C. The Psychometric Properties and Practicability of Self-Report Instruments to Identfy Medication Nonadherence in Adult Transplant Patients: A Systematic Review. Transplantation 2010;90(2):205-19.
  • Dew MA, Di Martini AF, De Vito Dabbs A, Myaskovsky L, Steel J, Unruh M et al. Rates and Risk Factors for Nonadherence to the Medical Regimen After Adult Solid Organ Transplantation. Transplantation 2007;83:858-73.
  • Dew MA, DeVito Dabbs A, Myaskovsky L, Shyu S, Shellmer DA, DiMartini AF et al. Meta-Analysis of Medical Regimen Adherence Outcomes in Pediatric Solid Organ Transplantation. Transplantation 2009;88(5):736–46.
  • De Bleser L, Matteson M, Dobbels F, Russell C, De Geest, S. Interventions to Improve Medication Adherence After Transplantation: a systematic review. Transplant International 2009;22:780-97.
  • De Bleser L, Dobbels F, Berben L, Vanhaecke J, Verleden G, Nevens F et al. The Spectrum of Nonadherence with Medication in Heart, Liver, and Lung Transplant Patients Assessed in Various Ways. Transplant International 2011;24:882-91.
  • Brown M, Bussell JK. Medication Adherence: WHO Cares? Mayo Clinic Proceedings 2011;86(4):304-14.
  • Berquist RK, Berquist WE, Esquivel CO, Cox KL, Wayman KI, Litt IF. Non-Adherence to PostTransplant Care: Prevalence, Risk Factors and Outcomes in Adolescent Liver Transplant Recipients. Pediatric Transplantation 2008;12:194–200.
  • Balkrishnan R. The Importance of Medication Adherence in Improving Chronic-Disease Related Outcomes: What We Know and What We Need to Further Know. Medical Care 2005;43:517.
  • Ayna KT, Çiftçi ŞH, Tozkır H, Gürteki M, Çarin M. İmmunsupresif İlaçların Etki Mekanizmaları. Gaziantep Tıp Dergisi 2009;15(3):42-7.
Anadolu Hemşirelik ve Sağlık Bilimleri Dergisi-Cover
  • ISSN: 1309-5471
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Atatürk Üniversitesi Hemşirelik Fakültesi
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