Obeziteyi Önleyen Gıda Bileşenleri

Obezite son yıllarda çok sık rastlanan, sadece tıbbi yönü ile değil, sosyal ve ekonomik boyutlarıyla da değerlendirilmesi gereken önemli bir halk sağlığı sorunudur. Dünya Sağlık Örgütü verilerine göre obezite ve obeziteye bağlı hastalıklar dünyada her yıl 1 milyondan fazla insanın ölümüne neden olmaktadır. Beslenme bilimi beslenmenin insan sağlığı üzerine etkilerini, beslenme şekli ile bazı hastalıkların görülme sıklığı arasında doğrudan ilişkili olduğunu kanıtlamıştır. Bugün yeni bilgiler ışığında obezite hastalığı ile ilgili, ulusal beslenme politikaları geliştirmek, kamu organizasyonlarının ve gıda sektörünün sorumlulukları çerçevesinde yer almaktadır. Obeziteyi önlemek ya da azaltmak için yağ ve karbonhidratların kilo alımına etkisini azaltıcı yeni stratejiler geliştirilmesi ve değerlendirilmesi gerekmektedir. Gıdalarda doğal olarak bulunan bazı gıda bileşenlerinin çeşitli mekanizmalar ile kilo kontrolünde etkili olduğu bildirilmekte ve obezitenin engellemesinde yeni bir yaklaşım olarak çalışılmaktadır. Bu derlemede, obeziteyi önleyici etki gösteren bazı gıdalar veya gıdalarda bulunan bazı biyoaktif bileşenler üzerine yapılan çalışmalar incelenmiş ve değerlendirilmiştir

Food Ingredients in Preventing Obesity

Obesity has become a major public health problem and should be considered with not only medical aspects also the social and economic aspects. According to the data of the World Health Organization (WHO), obesity and obesityrelated diseases cause the death of over a million people worldwide each year. Science of nutrition has proven the effects of nutrition on human health and direct correlation between nutritional habits and the frequency of some diseases. Improvement of national nutrition policies about obesity is within the framework of responsibilities of the public organizations and food industry by considering the new approaches. Development and evaluation of new strategies about reducing the effects of fat and carbohydrates on weight gain are required to prevent or reduce obesity. It has been reported that food constituents, which are naturally found in foods, may be effective on the control of weight gain via various mechanism and have been studied as a new approach for obesity prevention. In this article, recent studies about some foods or bioactive compounds found in foods, which can effect on obesity prevention, are reviewed

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Çayır, A., Atak, N., Köse S.K., 2011. Beslenme ve diyet kliniğine başvuranlarda obezite durumu ve etkili faktörlerin belirlenmesi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 64(1):13-19.
Trigueros, L., Peña, S., Ugidos, A.V., Sayas- Barbera, E., Pérez-Álvarez, J.A., Sendra E., 2012. Food ingredients as anti-obesity agents: a review. Critical Reviews in Food Science and Nutrition DOI:10.1080/10408398.2011.574215.
WHO, World Health Organization, 2005. The World Health Organisation. Preventing Chronic Disease: A Vital İnvestment: Who Global Report. Geneva, 56p.
Anonim, 2004. Sağlıklı Beslenelim, Kalbimizi Koruyalım" Projesi Araştırma Raporu. Sağlık Bakanlığı Müdürlüğü, Ankara, 83s. Hizmetleri Genel
Anonım, 2010, Türkiye Obezite (Şişmanlık) Ile Mücadele Ve Kontrol Programı (2010-2014). Sağlık Bakanlığı, Ankara, Yayın No: 773, 112s.
Birari, R.B., Bhutani, K.K., 2007. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discovery Today 12(19-20): 879- 889.
Wang, H., Du, Y., Song, H., 2010. ?-glucosidase and ?-amylase inhibitory activities of guava leaves. Food Chem. 123(1):6-13.
Kazemipoor, M., Radzi, C.W.J.W.M., Cordell, G.A., Yaze, I., 2012. Potential of traditional medicinal plants for treating obesity: a review, 2012 International Conference on Nutrition and Food Sciences, IPCBEE vol. 39 (2012) IACSIT Press, Singapore.
Li, J.J., Huang, C.J., Xie, D., 2008. Review anti- obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Mol. Nutr. Food Res. 52: 631-645.
Kim, H., Choi, S., Lee, H.J., Lee, J.H., Choi, H., 2003. Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. J. Biochem. Mol. Biol. 36:258-264.
Froyland, L., Madsen, L., Vaagenes, H.,Totland, G.K., Auwerx, J., Kryui, H., Staels, B., Berge, R.K., 1997. Mitochondrion is the principal target for nutritional and pharmacological control triglyceride metabolism. J. Lipid Res. 38:851-1858. of
Kim, H. K., Della-Fera, M., Lin, J., Baile, C.A., 2006. Docosahexaenoic differentiation and induces apoptosis in 3T3-L1 preadipocytes. J. Nutr. 136: 3965-3696. adipocyte
Buckley, J.D., Howe, P.R.C., 2009. Obesity management anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids. International Association for the Study of Obesity. Obesity Reviews 10: 648-659.
Hainault, I., Carlotti, M., Hajduch, E., Guichard, C., Lavau, M., 1993. Fish oil in a high lard diet prevents obesity, hyperlipidemia, and adipocyte insulin resistance in rats. Ann. NY Acad. Sci. 683: 98-101.
Baillie, R., Takada, R., Nakamura, M., Clarke, S., 1999. Coordinate induction of peroxisomal acyl- CoA oxidase and UCP-3 by dietary fishoil: a mechanism for decreased body fat deposition. Prostaglandins Leukot Essent Fatty Acids 60: 351- 356.
Aslan M., Orhan N., 2010, Obezite Tedavisine Yardımcı Olarak Kullanılan Doğal Ürünler, Mised, 23-24: 91:105.
Blankson, H., Jakop, A., Fapertun, H., 2000. Conjugated linoleic acid reduces body fat mass in overweigth and obese humans. J. Nutr. 130: 2943- 2948.
Riserus, U., Arner, P., Brismar, K., Vessby, B., 2002. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25: 1516-21.
Smedman, A., Vessby, B., 2001. Conjugated linoleic acid supplementation in humans--metabolic effects. Lipids 36(8):773-81.
Kamphuis, M.M.J.W., Lejeune, M.P.G.M., Saris, W.H.M., Westerterp-Plantenga, M.S., 2003. Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. Eur. J. Clin. Nutr. 57: 1268- 74.
Gaullier, J.M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik H., Gudmundsen, O., 2004. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am. J. Clin. Nutr. 79: 1118-1125.
Furlan, C.P.B.F., Marques, A.C., Marineli, R.S., Jşnior, M.R.M., 2013. Conjugated linoleic acid and phytosterols counteract obesity induced by high-fat diet. Food Res. Int. 51: 429-435.
Mhurchu, C.N. , 2004, The effect of the dietary supplement, chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults. Int. J. Obes. Relat. Metab. Disord. 28: 1149-56.
Ni, M.C, Dunshea-Mooij, CA, Bennett, D, Rodgers, A., 2005. Chitosan for overweight or obesity. Cochrane Database Syst Rev. 20(3): CD003892.
Kaats, G.R., Michalek, J.E., Preuss, H.G., 2006. Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol. Journal of the American College of Nutrition 25(5): 389- 394.
Tucci, S.A., Boyland, E.J., Halford, J.C.G., 2010. The role of lipit and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents, diabetes. Metabolic Syndrome and Obesity: Targets And Therapy 3: 125-143.
Garza A.L., Milagro F.I., Boque N., Campión J., Martínez J.A., 2011, Natural inhibitors of pancreatic lipase as new players in obesity treatment. Planta Med. 77(8): 773-785.
Gonçalves, R., Mateus, N., Freitas, V., 2011. Inhibition of a-amylase activity by condensed tannins. Food Chem. 125(2): 665-672.
Ikarashi, N., Takeda, R., Ito, K., Ochiai, W., Sugiyama, K., 2010. The ınhibition of lipase and glucosidase activities by acacia polyphenol. Ecam. Doi:10.1093/Ecam/Neq043, 1-7.
Ashok, P.K., Upadhyaya, K., 2012. Tannins are astringent. Journal of Pharmacognosy and Phytochemistry 1(3): 45-50
Sugiyama, H., Akazome, Y., Shoji, T., Yamaguchi, T., Yasue, M., Kanda, T., Ohtake, Y., 2007. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J. Agric. Food Chem. 55(11): 4604-4609.
He, Q., Lv, Y., Yao, K., 2007. Effects of tea polyphenols on the activities of a-amylase, pepsin, trypsin and lipase. Food Chem. 101(3):1178-1182.
Chitpan, M., 2009. Monitoring of the Binding Processes of Black Tea Polyphenols to Bovine Serum Albumin Surface Using Quartz Crystal Microbalance With Dissipation. Graduate School- New Brunswick Rutgers, The State University of New Jersey, Doctor of Philosophy Graduate Program in Food Science, New Brunswick, New Jersey.
Moreno, D.A., Ilic, N., Poulev, A., Brasaemle, D.L., Fried, S.K., Raskin I., 2003. Inhibitory effects of grape seed extract on lipases. Nutrition 19: 876- 879.
Moreno, D.A., Ilic, N., Poulev, A., Raskin, I., 2006. Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters. Life Sci. 78: 2797-2803.
Kimura, H., Ogawa, S., Katsube, T., Jisaka, M., Yokota, K., 2008. Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata BLUME) after treatment with wood ashes. J. Agric. Food Chem. 56: 4783-4788.
Lee, I.A., Lee, J.H., Baek, N.I., Kim, D.H., 2005. Antihyperlipitemic effect of crocin isolated from the fructus of gardenia jasminoides and its metabolite crocetin. Biol. Pharm. Bull. 28(11): 2106-2110.
Sheng, L., Qian, Z., Zheng, S., Xi, L., 2006. Mechanism of hypolipitemic effect of crocin in rats: crocin inhibits pancreatic lipase. Eur. J. Pharmacol. 543: 116-122.
Cederroth, C.R., Nef, phytoestrogens and metabolism: a review. Mol. Cell. Endocrinol. 304: 30- 42. S., 2009. Soy,
Dalais, F.S., Ebeling, P.R., Kotsopoulos, D., McGrath, B.P., Teede H.J., 2003. The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin. Endocrinol. 58: 704-709.
Wu, J., Oka, J., Higuchi, M., Tabata, I., Toda, T., Fujioka, M., Fuku, N., Teramoto, T., Okuhira, T., Ueno, T., Uchiyama, S., Urata, K., Yamada, K., Ishimi, Y., 2006. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism 5: 423-433.
Tolba, E.A.H.T., 2013. Dietary phytoestrogens reduce the leptin level in ovariectomized female rats, Environmental & Biological Sciences 1(3): 2320- 4079. of Chemical,
Yamashita, T., Sasahara, T., Pomeroy, S.E., Collier, G., Nestel, P.J., 1998. Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet. Metabolism 47: 1308-14.
Mikkelsen, P.B., Toubro, S., Astrup, A., 2000. Effect of fat-reduced diets on 24-h energy expenditure: comparisons between animal protein, vegetable protein, and carbohydrate. Am. J. Clin. Nutr. 72: 1135-41.
Zhang, Y., Chen, W., Guo, J., Fu, Z., Yi, C., Zhang, M., Na, X., 2013. Soy isoflavone supplementation could reduce body weight and improve glucose metabolism in non-Asian postmenopausal women- A meta-analysis. Nutrition 29(1): 8-14.
Suzuki, K., Konno, R., Shimizu, T., Nagashima, T., Kimura, A., 2007. A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice . J. Nutr. Sci. Vitaminol. 53: 63-67.
Clifton, P.M., Noakes, M., Sullivan, D., Erichsen, N., Ross, D., Annison, G., Fassoulakis, A., Cehun, M.,Nestel, P., 2004. Cholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereal. Eur. J. Clin. Nutr. 58: 503-509.
Rideout, T.C., Harding, S.V., Jones, P.J.H., 2010. Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. Mol. Nutr. Food Res. 54: 7-13
Takeshita, M., Saito, S., Moriwaki, J., Takase, N., Shiiba, D., Kudo, N., Nakajima, Y., Tokimitsu, I., 2007. Effects of dietary diacylglycerol oil containing phytosterols in mayonnaise on abdominal fat and blood cholesterol levels in Japanese men. Jpn. Pharmacol. Ther. 39: 973-987.
Zemel, M. B., Shi, H., Greer, B., DiRienzo, D., Zemel, P.C., 2000. Regulation of adiposity by dietary calcium. FASEB J. 14: 1132-1138.
Jacobsen, R., Lorenzen, J. K., Toubro, S. , Krog- Mikkelsen, I., Astrup, A., 2005. Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion. Int. J. Obesity. 29: 292-301.
Astrup, A., Kristensen, M., Gregersen, N.T., Belza, A., Lorenzen, J.K., Due, A., Larsen, T.M., 2010. Can bioactive foods affect obesity? Annals of the New York Academy of Sciences, Issue: Foods for Health in the 21st Century, Ann. N.Y. Acad. Sci. 1190, 25-41c, New York Academy of Sciences.
Zemel, M. B., 2005. The role of dairy foods in weight management. J. Am. Coll. Nutr. 24(6): 537- 546.
Shapses, S.A., Heshka, S., Heymsfield, S.B., 2004. Effect of calcium supplementationon weight and fat loss in women. J. Clin. Endocrinol. Metab. 89: 632- 637.
Fakhrawi, D.H., Lammi-Keefe, C.J., Beeson, W.L., Darnell, T.A., Cordero-MacIntyre, Z.R., 2013. Dairy calcium decreases adiposity, plasma leptin, and glucose in obese postmenopausal women. Nutrition Research, http://dx.doi.org/10.1016/j.nutres.2013.04.007.