Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities

Spirulina platensis simbiyotik, çok hücreli ve ipliksi yapıda mavi-yeşil mikroalgdir. Esansiyel aminoasitler, ?-karoten ve fikobiliproteinler gibi pigmentler ve eikosapentaenoik (EPA) ve dokosaheksaenoik asit (DHA) gibi çoklu doymamış yağ asitleri gibi bazı değerli biyoaktif bileşiklerin zengin bir kaynağıdır. Spirulina platensis ve ondan elde edilen biyoaktif peptitler besinsel ve antioksidan, antihipertansif, antimikrobiyal, antidiyabetik ve antiobezite etkiler gibi bazı medikal faydaları nedeniyle sağlıklı gıda bileşeni olarak gittikçe önem kazanmaktadır. Bu çalışma, Spirulina platensis'ten elde edilen biyoaktif peptitler ve onların bazı sağlık faydaları hakkında bilgi vermeyi amaçlamaktadır.

Mikroalg Spirulina platensis'ten Elde Edilen Biyoaktif Peptitler ve Biyofonksiyonel Aktiviteleri

Spirulina platensis is symbiotic, multicellular, and filamentous blue-green microalgae. It is a rich source of some highvalue bioactive molecules containing essential amino acids, pigments like ?-carotene and phycobiliproteins and polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Spirulina platensis and bioactive peptides derived from these microalgae are gaining more attention because of their nutritional and various medicinal properties like antioxidant, antihypertensive, antimicrobial, anti-diabetes and antiobesity activities. This study provides an overview about bioactive peptides derived from microalgae Spirulina platensis and their some biological activities with health benefits.

___

  • Ravi, M., De, S.L., Azharuddin, S., Paul, S.F.D., 2010. The beneficial effects of Spirulina focusing on its immunomodulatory and antioxidant properties. Nutrition and Dietary Supplements 2: 73-83.
  • Agustini, T.W., Suzery, M., Sutrisnanto, D., Ma'rufa, W.F., Hadiyanto, 2015. Comparative study of bioactive substances extracted from fresh and dried Spirulina sp. Procedia Environmental Sciences 23: 282-289.
  • Vo, T.S., Ngo, D.H., Kim, S.K., 2015. Nutritional and pharmaceutical properties of microalgal Spirulina. In Chapter 9: Handbook of Marine Microalgae, Edited by S.K. Kim,the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK, 568p.
  • Samarakoon, K., Jeon, Y.J., 2012. Bio- functionalities of proteins derived from marine algae - A review. Food Research International 48: 948-960.
  • Priyadarshani, I., Rath, B., 2012. Commercial and industrial applications of microalgae - A review. Journal of Algal Biomass Utilization 3(4): 89-100.
  • Yücetepe, A., Saroğlu, Ö., Bildik, F., Özçelik, B., 2016. Ultrasound assisted extraction of protein from Spirulina platensis; Determination of total phenolic contents and antioxidant activity of protein extracts and optimization of process parameters. The 1st Food Chemistry Conference: Shaping the Future of Food Quality, Health and Safety, October 30-November 1, 2016, Amsterdam, Holland.
  • Wang, L., Pan, B., Sheng, J., Xu, J., Hu, Q., 2007. Antioxidant activity of Spirulina platensis extracts by supercritical carbon dioxide extraction. Food Chemistry 105: 36-41.
  • El-Desouki, N.I., Tabl, G.A., Abdel-Aziz, K.K., Salim, E.I., Nazeeh, N., 2015. Improvement in beta-islets of Langerhans in alloxan-induced diabetic rats by erythropoietin and Spirulina. The Journal of Basic & Applied Zoology 71: 20-31.
  • Benelhadj, S., Gharsallaoui, A., Degraeve, P., Attia, H., Ghorbel, D., 2016. Effect of pH on the functional properties of Arthrospira (Spirulina) platensis protein isolate. Food Chemistry 194: 1056-1063.
  • Silveira, S.T., Burkert, J.F.M., Costa, J.A.V., Burkert, C.A.V., Kalil, S.J., 2007. Optimization of phycocyanin extraction from Spirulina platensis using factorial design. Bioresource Technology 98: 1629-1634.
  • Chaiklahan, R., Chirasuwan, N., Bunnaga, B., 2012. Stability of phycocyanin extracted from Spirulina sp.: Influence of temperature, pH and preservatives. Process Biochemistry 47: 659-664.
  • Yücetepe, A., Özçelik, B., 2016. Nutritional properties of microalgae. Gıda, Metabolizma & Sağlık: Biyoaktif Bileşenler ve Doğal Katkılar Kongresi, 28 Kasım 2016, İstanbul, Turkey, Book of Proceedings, 163-166p.
  • Becker, E.W., 2007. Micro-algae as a source of protein. Biotechnology Advances 25: 207-210.
  • http://www.egemacc.com/tcpdf/examples/pdf.php? a=79&lng=1. Erişim tarihi: 24.11.2016
  • Ngo, D.H., Vo, T.S., Ngo, D.G., 2012. Biological activities and potential health benefits of bioactive peptides International Journal of Biological Macromolecules 51: 378-383. marine organisms.
  • Kim, S.K., Wijesekara, I., 2010. Development and biological activities of marine-derived bioactive peptides: A review. Journal of Functional Foods 2: 1-9.
  • Wijesinghe, W.A.J.P., Jeon, Y.J., 2012. Enzymeassistant extraction (EAE) of bioactive components: A useful approach for recovery of industrially important metabolites from seaweeds: A review. Fitoterapia 83: 6-12.
  • Gür, F., Güzel, M., Öncül, N., Yıldırım, Z., Yıldırım, M., 2010. Süt serum proteinleri ve türevlerinin biyolojik ve fizyolojik aktiviteleri. Akademik Gıda 8(1): 23-31.
  • Suetsuna, K., Chen, J.R., 2001. Identification of antihypertensive peptides from peptic digests of two microalgae, Chlorella vulgaris and Spirulina platensis. Marine Biotechnology 3: 305-309.
  • Zhang, B., Zhang, X., 2013. Separation and nanoencapsulation of antitumor polypeptide from Spirulina platensis. Biotechnology Progress 29(5): 1230-1238.
  • Sun, Y., Chang, R., Li, Q., Li, B., 2015. Isolation and characterization of an antibacterial peptide from protein hydrolysates of Spirulina platensis. European Food Resarch Technolgy 1-8.
  • He, H.L., Chen, X.L., Wu, H., Sun, C.Y., Zhang, Y.Z., Zhou, B.C., 2007. High throughput and rapid screening of marine protein hydrolysates enriched in peptides with angiotensin-I-converting enzyme inhibitory activity by capillary electrophoresis. Bioresource Technology 98: 3499-3505.
  • Yu, J., Hu, Y., Xue, M., Dun, Y., Li, S., Peng, N., Liang, Y., Zhao, S., 2016. Purification and identification of antioxidant peptides from enzymatic hydrolysate of Spirulina platensis. Journal of Microbiology and Biotechnology 26(7): 1216-1223.
  • Wang, Z.J., Zhang, X.W., 2016. Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth. Food & Function 7(2): 781-788.
  • Lu J., Ren D.F., Xue, Y.L., Sawano, Y., Miyakawa, T., Tanokura, M., 2010. Isolation of an antihypertensive peptide from alcalase digest of Spirulina platensis. Journal of Agricultural and Food Chemistry 58(12): 7166-7171.
  • Kim, N.H., Jung, S.H., Kim, J., Kim, S.H., Ahn, H.J., Bin, S.K., 2014. Purification of an ironchelating peptide from Spirulina protein hydrolysates. Journal of the Korean Society for Applied Biological Chemistry 57(1): 91-95.
  • Lu, J., Ren, D.F., Wang, J.Z., Tanokura, M., 2010. Purification and characterization of an angiotensin ı -converting enzyme inhibitory peptide derived from Spirulina platensis. Progress in Biochemistry and Biophysics 37(5): 568-574.
  • Estrada, J.E.P., Bescos, P.B., Fresno, A.M.V., 2001. Antioxidant activity of different fractions of Spirulina platensis protean extract. Il Farmaco 56: 497-500.
  • Gad, A.S., Khadrawy, Y.A., El-Nekeety, A.A., Mohamed, S.R., Hassan, N.S., Abdel-Wahhab, M.A., 2011. Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats. Nutrition 27: 582-589.
  • El-Tantawy, W.H., 2015. Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats. Journal of Traditional and Complementary Medicine 1-5.
  • Bermejo, P., Pinero, E., Villar, A.M., 2008. Ironchelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulina platensis. Food Chemistry 110: 436-445.
  • Ercan, P., El, S.N., 2016. Inhibitory effects of chickpea and Tribulus terrestris on lipase, alphaamylase and alpha-glucosidase. Food Chemistry 205: 163-169.
  • Layam, A., Reddy, C.L.K., 2006. Antidiabetic property of Spirulina. Diabetologia Croatica 35-2.
  • Pagnussatt, F.A., Ponte, E.M.D., Garda-Buffon, J., Furlong, B., 2014. Inhibition of Fusarium graminearum growth and mycotoxin production by phenolic extract from Spirulina sp. Pesticide Biochemistry and Physiology 108: 21-26.
Akademik Gıda-Cover
  • ISSN: 1304-7582
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2003
  • Yayıncı: Sidas Medya Limited Şirketi
Sayıdaki Diğer Makaleler

Kayısı Çekirdek Yağının Biyokimyasal Özellikleri ve Oksidatif Stabilitesi Üzerine Ekstraksiyon Yönteminin Etkisi

Sibel ULUATA

Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities

Aysun YÜCETEPE, Beraat ÖZÇELİK

Yakın-Kızılötesi (NIR) Spektroskopisi Kullanılarak Koyun, Keçi ve İnek Sütlerinin Tanımlanması

İsmail Hakkı BOYACI, Şahin DURNA, Atilla YETİŞEMİYEN, Hüseyin Efe GENİŞ

Yakın-Kızılötesi NIR Spektroskopisi Kullanılarak Koyun, Keçi ve İnek Sütlerinin Tanımlanması

Şahin DURNA, Atilla YETİŞEMİYEN, Hüseyin Efe GENİŞ, İsmail Hakkı BOYACI

İran ve Türkiye Safranları Kullanılarak Yapılan Pudinglerde Dokusal Kalite Özelliklerindeki Değişimlerin Objektif ve Subjektif Yöntemlerle İncelenmesi

Gülden OVA, Saeid Chobdar RAHİM

Changes in Rheological Properties of Koruk (Unripe Grape) Juice Concentrates During Vacuum Evaporation

Filiz İÇİER, Serdal SABANCI, Mutlu ÇEVİK, Derya TEZCAN

Ege Bölgesi’nde Satışa Sunulan Kuru Üzümlerde Okratoksin A ve Küf İlişkisi

Gözde TÜRKÖZ BAKIRCI, Fatih ÇAKMAK, Dilara ÖZDEMİR

Bazı Fermente Gıdalardan İzole Edilen Lactobacillus plantarum Suşlarının Metal Dirençlilik Özellikleri

Halil İbrahim KAYA, Burcu ÖZEL, Ömer ŞİMŞEK

Gıda İşletmelerinde Kullanılan Suların Gıda Güvenliği Yönünden İncelenmesi

Harun URAN, Bayram ÇETİN, Hatice ALOĞLU ŞANLIDERE, Şeyda KARABULUT YANARDAĞ

Gama-orizanol

Neşe TUNCEL YILMAZ