SEVİM KARAKAŞ ÇELİK, Nurcan ARAS ATEŞ, Badel ARSLAN MAMUR, Mehmet Özgür TÜRKMENOĞLU

SULT1A1 R213H gen polimorfizmi ile mide kanseri arasındaki ilişki

Giriş ve Amaç: Ülkemizde gastrointestinal sistem kanserleri, akciğer kanserinden sonra en sık görülen kanserlerden birisidir. Mide kanseri ise gastrointestinal sistem kanserlerinin en sık rastlanılan tümörüdür. Yapılan çalışmalar, ksenobiyotik metabolizmasından sorumlu genler- deki polimorfizmlerin bireylerin kanser riskini değiştirebileceği üzerine yoğunlaşmaktadır. Sülfotransferazlar, ksenobiyotik metabolize eden enzim grubunda bulunmakta olup, bu enzim grubu endojen ve eksojen kimyasalların detoksifikasyonu ve biyoaktivasyonunda rol oynamakta- dırlar. Bu çalışmada SULT1A1 gen polimorfizmi ile mide kanseri ara- sında ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntem: SULT1A1 geni R213H polimorfizmi 59 mide kanseri hastası ve 80 kontrol bireyde polimeraz zincir reaksiyonu/restriksiyon parça uzunluğu polimorfizmi yöntemi kullanılarak belirlenmiştir. Bulgular: Kontrol grubu ile hasta grubunu oluşturan mide kanserli bireyler karşılaştırıldığında, SULT1A1 Arg/His genotipini taşımanın mide kanseri açısından koruyucu etki gös- terdiği tespit edilmiştir (p=0.017). Ayrıca sigara içmeyen bireylerde Arg/ His genotipinin koruyuculuk etkisinin daha da belirginleştiği dikkat çek- mektedir. Sonuç: Sonuç olarak elde edilen bulgular SULT1A1 His poli- morfizmini heterozigot taşıyan bireylerin mide kanseri patogenezinde rol oynayan karsinojenlere karşı daha iyi bir koruma sistemleri olduğunu göstermektedir.

Relationship between gastric cancer and SULT1A1 R213H gene polymorphism

Background and Aims: After lung cancer, gastrointestinal cancer is one of the most common cancers in our country. Gastric cancer is the most common gastrointestinal cancer. Recent studies have been fo- cused on polymorphisms in genes responsible for xenobiotic metab- olism that may alter the risk of cancer. Sulfotransferases are in the group of xenobiotic metabolizing enzymes involved in the bioactiva- tion and detoxification of endogenous and exogenous chemicals. In this study, we aimed to investigate the relationship between SULT1A1 gene polymorphisms and gastric cancer. Material and Methods: SULT1A1 R213H gene polymorphisms were determined in 59 gastric cancer patients and 80 control subjects by using polymerase chain re- action-restriction fragment length polymorphism. Results: Our results indicate that SULT1A1Arg/His genotype carriers have increased protec- tion against gastric cancer compared with the control group. In addi- tion, it is noteworthy that the protective effect of the Arg/His genotype is more pronounced in non-smoking individuals. Conclusion: These findings suggest that heterozygous individuals for the SULT1A1 R213H polymorphism have better protection against carcinogens that play a role in the pathogenesis of gastric cancer.

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