Ali Rıza KÖKSAL, Hüseyin ALKIM, Salih BOĞA, Mehmet BAYRAM, İlker ŞEN, Ayşe Ayşim ÖZAĞARI, CANAN ALKIM

Özofageal heterotopik gastrik mukoza: ne kadar sık? Ne kadar önemli? Bir vaka-kontrol çalışması

Giriş ve Amaç: Heterotopik gastrik mukoza genellikle servikal özofagusta yerleşen, çoğunlukla asemptomatik olan ve ilerleyici olmayan kolumnar mukozal adacıktır. Çalışmamızda kliniğimizde endoskopik olarak heterotopik gastrik mukoza tanısı konan vakaların klinikopatolojik özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmada Ocak 2009-Aralık 2013 tarihleri arasında gastroskopi yapılan vakaların verileri retrospektif olarak incelendi. Endikasyonu bilinmeyen, mükerrer ve acil vakalar çalışma dışı bırakıldı. Epidemiyolojik analizler sonrası dispepsi yakınması ile gastroskopi yapılan gruptan heterotopik gastrik mukoza olguları ile yaş ve cinsiyet eşlenik bir kontrol grubu oluşturuldu. Heterotopik gastrik mukoza ve kontrol grubunun klinikopatolojik özellikleri karşılaştırıldı. Bulgular: Çalışmaya 7244ü kadın (%56.7) toplam 12.767 hasta alındı. Hastaların yaş ortalaması 52.4±16.5 yıl idi. 137 vakada (%1.1) heterotopik gastrik mukozaya rastlandı. Vakaların %90.1i proksimal özofagusta idi. Heterotopik gastrik mukoza oranı en yüksek işlem endikasyonları; Barrett özofagus kontrol (%6.5), üst özofageal semptomlar (%2) ve bulantı kusma (%1.7) idi. Heterotopik gastrik mukoza prevalansı kadınlarda %0.7 iken erkeklerde %1.5 bulundu (p

Oesophageal heterotopic gastric mucosa: how often? How important? A case-control study

Background and Aims: Heterotopic gastric mucosa is a columnar mucosal islet, commonly located in the cervical esophagus, that is usually asymptomatic and nonprogressive. In this study, we aimed to evaluate the clinicopathological features of heterotopic gastric mucosa cases in our clinic that were diagnosed using endoscopy. Materials and Method: In this study, we retrospectively analyzed data from patients who underwent gastroscopy between January 2009 and December 2013, excluding procedures performed for unknown indications, or repeated, or urgent gastroscopies. After completing epidemiological analysis, an age and gender matched control group was attained from patients whose gastroscopy was done due to dyspepsia. We compared clinico- pathological characteristics of the heterotopic gastric mucosa and con- trol groups. Results: A total of 12.767 patients, 7.244 (56.7%) female, were included in the study. Mean patient age was 52.4±16.5 years. Heterotopic gastric mucosa accounted for 137 (1.1%) of the cases. Ninety percent were in the proximal esophagus. The highest hetero- topic gastric mucosa rates in follow up examiniations were idenntified as: Barretts esophagus (6.5%), upper esophageal symptoms (2%), and nausea/vomiting (1.7%). Heterotopic gastric mucosa prevalence was 0.7% in females and 1.5% in males (p <0.01). The average age of the heterotopic gastric mucosa group was significantly younger than the non- heterotopic gastric mucosa group (47.9±15 and 52.5±16, p <0.01). Conclusion: The presence of heterotopic gastric mucosa was more frequent in patients with upper oesophageal symptoms resistant to treatment; male patients under 50 years of age; and, in patients with a history of Barretts esophagus.

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