Malign özofageal disfajisi olan vakalarda içten kaplı kendiliğinden genişleyebilen metal stent uygulamalarımızın etkinlik ve güvenliğinin değerlendirilmesi
Giriş ve Amaç: Kendiliğinden genişleyebilen metalik stentler malign disfajide palyatif bir tedavi yöntemidir. Çalışmamızın amacı malign özofagus darlıklarında içten kaplı kendiliğinden genişleyebilen metalik stent uygulamalarımızın etkinlik ve güvenliğini değerlendirmektir. Gereç ve Yöntem: Ocak 2014-Temmuz 2015 tarihleri arasında Keçiören Eğitim ve Araştırma Hastanesi Gastroenteroloji Kliniğinde malign disfaji nedeni ile içten kaplı kendiliğinden genişleyebilen metalik stent uygulanmış 22 hasta çalışmaya dahil edildi. Hastalar, yaş, cinsiyet, primer malig- nensi odağı, darlık uzunluğu, darlık lokasyonu, trakeözofageal fistül varlığı açısından değerlendirildiler. Hastalar işlem ilişkili komplikasyonlar açısından takip edildiler. Ortalama takip süresi 28 hafta idi (4 ila 48 hafta). Bulgular: 19 hasta (86%) erkek ve 3 (14%) hasta kadındı. En genç hasta 31, en yaşlı hasta 72 yaşında idi (ortalama yaş: 58,1±10,4 yıl). Ortalama disfaji skorları stent uygulamasından önce 3.0±0.61 iken, kendiliğinden genişleyebilen metalik stent sonrası 1,1±0,75e geriledi. Hastalarımızda işlem ilişkili ciddi komplikasyon yaşanmadı. Sonuç: Kliniğimizde malign disfajilerde beslenmenin devamının sağlanması ve disfaji palyasyonu açısından tercih edilen içten kaplı kendiliğinden genişleyebilen metalik stentler son derecede etkili ve güvenli bir şekilde uygulanmaktadır.
Evaluation of efficacy and safety of our experiences with internally covered self-expandable metal stent in cases with malignant esophageal dysphagia
Background and Aims: Self-expandable metal stents are an established palliative therapy for malignant dysphagia. The aim of our study was to evaluate the efficacy and safety of our experiences with internally covered self-expandable metal stents in cases with malignant esophageal strictures. Materials and Methods: 22 patients with advanced malignant dysphagia, who underwent esophageal internally covered self-expandable metal stent implementation at Keçioren Research and Training Hospital, Department of Gastroenterology between January 2015 and July 2015, were included in this study. The patients were evaluated for age, gender, primary malignancy focus, stricture location and length, and presence of tracheoesophageal fistula. Follow up for procedure related complications and dysphagia scores was performed, with a mean follow-up time of 28 weeks (range, 4 to 48). Results: 19 patients, (86%) were male and 3 (14%) female, were included in the study. The youngest patient was 31 years of age, while the oldest was 72 years of age (mean age, 58,1±10,4 years). Mean dysphagia scores (scale 0-4) improved from 3.0±0.61 to 1.1±0.75 after self-expandable metal stent implantation. There were no procedure-related major complications in this series. Conclusion: In our clinic, internally covered self-expandable metal stents, which are preferred for maintaining the nutrition and palliation of dysphagia in cases with malignant dysphagia, are used safely and effectively.
___
- 1. OSullivan GJ, Grundy A. Palliation of malignant dysphagia with expanding metallic stents. J Vasc Interv Radiol 1999;10:346-51.
- 2. Munoz JC. Esophageal stenting in patients with advanced esopha- geal cancer. Northeast Florida Medicine 2010;61:33-8.
- 3. Weigel TL, Frumiento C, Gaumintz E. Endoluminal palliation for dysphagia secondary to esophageal carcinoma. Surg Clin North Am 2002;82:747-61.
- 4. Shridhar R, Almhanna K, Meredith KL, et al. Radiation therapy and esophageal cancer. Cancer Control 2013;20:97-110.
- 5. Bethge N, Sommer A, Vakil N. A prospective trial of self-expand- ing metal stents in the palliation of malignant esophageal stric- tures near the upper esophageal sphincter. Gastrointest Endosc 1997;45:300-3.
- 6. Maier A, Tomaselli F, Gebhard F, et al. Palliation of advan-ced esophageal carcinoma by photodynamic therapy and irradiation. Ann Thorac Surg 2000;69:1006-9.
- 7. Llano RC. Endoscopic techniques for gastrointestinal stenting: when and how to stent, how to manage complications, stent se- lection and costs. Rev Col Gastroenterol 2012; 27:31-42.
- 8. Minsky BD. Choosing the correct modality for the treatment of dysphagia in the patient with esophageal cancer. J Support Oncol 2006;4:377.
- 9. Mason RC, Bright N, McColl I. Palliation of malignant dysphagia with laser therapy: predictability of results. Br J Surg 1991;78:1346-7.
- 10. Frimberger E. Endoscopic treatment of benign esophageal stric- ture. Endoscopy 1983;15(Suppl 1):199-202.
- 11. Kim JY, Kim SG, Lim JH, et al. Clinical outcomes of esophageal stents in patients with malignant esophageal obstruction according to palliative additional treatment. J Dig Dis 2015 Aug 27. [Epub ahead of print].
- 12. Talreja JP, Eloubeidi MA, Sauer BG, et al. Fully covered remov- able nitinol self-expandable metal stents (SEMS) in malignant strictures of theesophagus: a multicenter analysis. Surg Endosc 2012;26:1664-9.
- 13. Vakil N, Morris AI, Marcon N, et al. A prospective, randomized, controlled trial of covered expandable metal stents in the palliation of malignant esophageal obstruction at the gastroesophageal junc- tion. Am J Gastroenterol 2001;96:1791-6.
- 14. Philips P, North DA, Scoggins C, et al. Gastric esophageal stenting for malignant dysphagia: results of prospective clinical trial evalua- tion of long-term gastroesophageal reflux and quality of life-related symptoms. J Am Coll Surg 2015;221:165-73.
- 15. Mariette C, Gronnier C, Duhamel A; FREGAT Working Group FRENCHAFC;FREGAT Working Group-FRENCH-AFC. Self-ex- panding covered metallic stent as a bridge to surgery in esoph- ageal cancer: impact on oncologic outcomes. J Am Coll Surg 2015;220:287-96.
- 16. Wen L, Quan H, Li L, et al. The clinical research of the endo- scopic sequential treatment for patients with intermediate-ad- vancedesophageal cancer: a randomized clinical trial. Med Oncol 2014;31:284-9.