___

• 1. Simboli-Campbell, M., et al., 1,25-Dihydroxyvitamin D3 translocates protein kinase C beta to nucleus and enhances plasma membrane association of protein kinase C alpha in renal epithelial cells. J Biol Chem, 1994. 269(5): p. 3257-64.2. Diaz, G.D., et al., Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. Cancer Res, 2000. 60(8): p. 2304-12. 3 . Haussler, M.R., et al., The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res, 1998. 13(3): p. 325-49.4 Barsony, J., et al., Immunocytology with microwave-fixed fibroblasts shows 1 alpha,25-dihydroxyvitamin D3-dependent rapid and estrogen-dependent slow reorganization of vitamin D receptors. J Cell Biol, 1990. 111(6 Pt 1): p. 2385-95.5 Fedirko, V., et al., Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev, 2010. 19(1): p. 280-916 Freedman, L.P., Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. J Nutr, 1999. 129(2S Suppl): p. 581S-586S.7 Zehnder, D., et al., Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab, 2001. 86(2): p. 888-94.8 Hsu, J.Y., et al., Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition. Cancer Res, 2001. 61(7): p. 2852-6.9 Friedrich, M., et al., Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissue. Anticancer Res, 2006. 26(4A): p. 2615-20.10 Matusiak, D., et al., Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon. Cancer Epidemiol Biomarkers Prev, 2005. 14(10): p. 2370-6.11 Lointier, P., et al., The role of vitamin D3 in the proliferation of a human colon cancer cell line in vitro. Anticancer Res, 1987. 7(4B): p. 817-21.12 Shabahang, M., et al., 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition. Cancer Res, 1993. 53(16): p. 3712-8.13 Sheinin, Y., et al., In situ mRNA hybridization analysis and immunolocalization of the vitamin D receptor in normal and carcinomatous human colonic mucosa: relation to epidermal growth factor receptor expression. Virchows Arch, 2000. 437(5): p. 501-7.14 Elloul, S., et al., Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer, 2005. 103(8): p. 1631-43.15 Otani, T., et al., Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer, 2007. 97(3): p. 446-51.16 Grau, M.V., et al., Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst, 2003. 95(23): p. 1765-71.17 Wactawski-Wende, J., et al., Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med, 2006. 354(7): p. 684-96.18 Garland, C.F., et al., Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet, 1989. 2(8673): p. 1176-819 Cross, H.S., et al., Growth control of human colon cancer cells by vitamin D and calcium in vitro. J Natl Cancer Inst, 1992. 84(17): p. 1355-7.20 Hulla, W., et al., Growth control of human colon-adenocarcinoma-derived Caco-2 cells by vitamin-D compounds and extracellular calcium in vitro: relation to c- myc-oncogene and vitamin-D-receptor expression. Int J Cancer, 1995. 62(6): p. 711-6.21 Matusiak, D., et al., Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon. Cancer Epidemiol Biomarkers Prev, 2005. 14(10): p. 2370-6.22 Deeb, K.K., D.L. Trump, and C.S. Johnson, Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer, 2007. 7(9): p. 684- 700.23 Zhang, Y., J. Zhang, and G.P. Studzinski, AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells. Cell Cycle, 2006. 5(4): p. 447-51.24 Hughes, P.J. and G. Brown, 1Alpha,25-dihydroxyvitamin D3-mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc- mediated activation of the RAS/RAF/ERK-MAP kinase signalling pathway. J Cell Biochem, 2006. 98(3): p. 590-617.25 Kure, S., et al., Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. Cancer Epidemiol Biomarkers Prev, 2009. 18(10): p. 2765-72.26 Thomas, M.G., et al., Vitamin D receptor expression in colorectal cancer. J Clin Pathol, 1999. 52(3): p. 181-3.27 Meggough F, L.P., Saez S, Sex steroid and 1,25-dihydroxy vitamin D3 receptors in human colorectal adenocarcinoma and normal mucosa. Cancer Res 1991. 5: p. 1227-30.28 Kane, K.F., M.J. Langman, and G.R. Williams, 1,25-Dihydroxyvitamin D3 and retinoid X receptor expression in human colorectal neoplasms. Gut, 1995. 36(2): p. 255-8.29 Meggough F, Lointier P, Pezet D, Saez S; Evidence of 1,25-dihydroxyvitamin D3-receptors in human digestive mucosa and carcinoma tissue taken at different levels of digestive tract, in 152 patients, J Steroid Biochem, 1990 Jun; 36(1-2):143-730 Lointier P, Meggough F, Dechelotte P, Pezet D, Ferrier C, Chipponi J, Saez S; 1,25-Dihydroxyvitamin D3 receptors and human colon adenocarcinoma Br J Surs; 1991 Apr; 78(4):435-931 Welsh, J., Vitamin D and breast cancer:insights from animal models. American Journal of Clinical Nutrition, 2004. 80(6): p. 1721-1724. and Malignant Breast Tissue. Anticancer Research, 2009. 29: p. 155-158.32 Stephanie L. Hines, M.D., H. Keels S. Jorn, M.D., Kristine M. Thompson, M.D., and Jan M. Larson, M.D. , Breast cancer survivors and vitamin D: A review. Nutrition, 2010. 26: p. 255-262.33 Rebecca Suk Heist, W.Z., Zhaoxi Wang, Geoffrey Liu, Donna Neuberg, Li Su, Kofi Asomaning, and T.J.L. Bruce W. Hollis, John C. Wain, Edward Giovannucci, and David C. Christiani, Circulating 25-Hydroxyvitamin D, VDR Polymorphisms,and Survival in Advanced Non–Small-Cell Lung Cancer. journal of clinical oncology, 2008. 26: p. 34.34 Martin Blomberg Jensena, C.B.A., John E. Nielsena, Per Bagic, and A.J. Anne Jørgensena, Henrik Leffers Expression of the vitamin D receptor, 25-hydroxylases, 1-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. Journal of Steroid Biochemistry & Molecular Biology, 2010. 121: p. 37382.35 Cross, H.S., et al., The Vitamin D endocrine system of the gut--its possible role in colorectal cancer prevention. J Steroid Biochem Mol Biol, 2005. 97(1-2): p. 121- 8.