Selman ÇELEBİ, Hüseyin Ataseven Eylem MENGÜCÜK, S. Erhan DEVECİ, Eylem MENGÜCÜK, Yasemin AÇIK, İ. Halil BAHÇECİOĞLU

Elazığ kent toplumunda nonalkolik yağlı karaciğerin epidemiyolojik özellikleri

Anahtar Kelimeler:

Nonalkolik yağlı karaciğer, prevalans, Türkiye

Epidemiologic features of nonalcoholic fatty liver in urban community of Elazığ

Background/aim: Nonalcoholic fatty liver disease is common in industrialized societies, but epidemiological data of nonalcoholic fatty liver disease is insufficient in Turkey. The aim of this study was to determine the prevalence of nonalcoholic fatty liver disease diagnosed by ultrasonography and the risk factors in an eastern Turkish general population. Materials and methods: A hepatobiliary ultrasonography was performed on 459 subjects randomly selected from the general population in Elaz›ğ. Body mass index and waist circumference were calculated and serum lipids, glucose, viral serology and aminotransferases levels were measured. In statistical analysis, chi-square, t-test and logistic regression were used. Results: 408 subjects ranging in age from 18 to 80 years participated in the study. After four persons were excluded (1 for regular alcohol consumption and 3 for chronic viral hepatitis), the remaining 404 persons were evaluated. Prevalence of Nonalcoholic fatty liver disease was 16.5% in females, 23.7% in males (p

Keywords:

Nonalcoholic fatty liver disease, prevalence, Turkey,

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Sanyal AJ. American Gastroenterological Association. AGA techni- cal review on nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 1705-25.
Bugianesi E, Leone N, Vanni E et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepa- tocellular carcinoma. Gastroenterology 2002; 123: 134-40.
Caldwell SH, Oelsner DH, Iezzoni JC et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999; 29: 664-9.
Browning JD, Szczepaniak LS, Dobbins R et al. Prevalence of hepa- tic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40: 1387-95.
Nomura H, Kashiwagi S, Hayashi J et al.Prevalence of fatty liver in a general population of Okinawa, Japan. Jpn J Med 1988; 27: 142- 9.
Bellentani S, Tiribelli C, Saccoccio G et al. Prevalence of chronic liver disease in the general population of northern Italy: the Diony- sos Study. Hepatology 1994; 20: 1442-9.
Omagari K, Kadokawa Y, Masuda J et al. Fatty liver in non-alcoho- lic non-overweight Japanese adults: incidence and clinical charac- teristics. J Gastroenterol Hepatol 2002; 17: 1098-105.
Shen L, Fan JG, Shao Y et al. Prevalence of nonalcoholic fatty liver among administrative officers in Shanghai: an epidemiological sur- vey. World J Gastroenterol 2003; 9: 1106-10.
Fang JG, Zhu J, Li XJ et al. Epidemiological survey of prevalence of fatty liver and its risk factors in a general adult population of Shanghai. Zhonghua Gan Zang Bing Za Zhi 2005; 13: 83-8. [Abst- ract]
Saito Y, Yagyu K, Hattori Y , et al. A study on fatty liver in health examination participants. Nippon Eiseigaku Zasshi 1989; 44: 953- 61. [Abstract]
Singh SP, Nayak S, Swain M et al. Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonograp- hic survey. Trop Gastroenterol 2004; 25: 76-9.
Bedogni G, Bellentani S. Fatty liver: How frequent is it and why? Annals of Hepatology 2004; 3: 63-65
Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepati- tis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37: 1202-19.
Lonardo A. Fatty liver and nonalcoholic steatohepatitis. Where do we stand and where are we going? Dig Dis 1999; 17: 80-9.
Marceau P, Biron S, Hould FS et al. Liver pathology and the meta- bolic syndrome X in severe obesity. J Clin Endocrinol Metab 1999; 84: 1513-7.
Chitturi S, Farrell GC, George J. Non-alcoholic steatohepatitis in the Asia-Pacific region: future shock? Gastroenterol Hepatol 2004; 19: 368-74.
Ozsahin AK, Gokcel A, Sezgin N et al. Prevalence of the metabolic syndrome in a Turkish adult population. Diabetes Nutr Metab 2004; 17: 230-4.
Tezcan S, Altintas H, Sonmez R et al. Cardiovascular risk factor le- vels in a lower middle-class community in Ankara, Turkey. Trop Med Int Health 2003; 8: 660-7.
Onal AE, Erbil S, Ozel S , et al. The prevalence of and risk factors for hypertension in adults living in Istanbul. Blood Press 2004; 13: 31-6.
Erem C, Arslan C, Hacihasanoglu A et al. Prevalence of obesity and associated risk factors in a Turkish population (trabzon city, Tur- key). Obes Res 2004; 12: 1117-27.
Ozdemir L, Topcu S, Nadir I et al. The prevalence of diabetes and impaired glucose tolerance in Sivas, Central Anatolia, Turkey. Di- abetes Care 2005; 28: 795-8.
Gore RM. Diffuse liver disease. In: Gore RM, Levine MS, Laufer I, eds. Textbook of gastrointestinal radiology. Philadelphia: Saunders, 1994: 1968–2017.
Yajima Y, Ohta K, Narui T et al. Ultrasonographical diagnosis of fatty liver: signifcance of the liver kidney contrast. Tohoku J Exp Med 1983; 139: 43–50.
Falck-Ytter Y, Younossi ZM, Marchesini G et al. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Li- ver Dis 2001; 21: 17-26.
Lonardo A, Trande P. Are there any sex differences in fatty liver? A study of glucose metabolism and body fat distribution. J Gastroen- terol Hepatol 2000; 15: 775-82.
Bellentani S, Saccoccio G, Masutti F et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000; 132: 112-7.
Assy N, Kaita K, Mymin D et al. Fatty infiltration of liver in hyper- lipidemic patients. Dig Dis Sci 2000; 45: 1929-34.
Loguercio C, De Girolamo V, de Sio I et al. Non-alcoholic fatty li- ver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects. J Hepatol 2001; 35: 568-74.
Kral JG, Schaffner F, Pierson RN Jr et al. Body fat topography as an independent predictor of fatty liver. Metabolism 1993; 42: 548-51.
Gillum RF, Mussolino ME, Madans JH. Body fat distribution and hypertension incidence in women and men. The NHANES I Epide- miologic Follow-up Study. Int J Obes Relat Metab Disord 1998; 22: 127-34.
Ludwig J, Viggiano TR, McGill DB et al. Nonalcoholic steatohepa- titis: Mayo Clinic experiences with a hitherto unnamed disease. Ma- yo Clin Proc 1980; 55: 434-8.
Diehl AM, Goodman Z, Ishak KG. Alcohollike liver disease in no- nalcoholics. A clinical and histologic comparison with alcohol-in- duced liver injury. Gastroenterology 1988; 95: 1056-62.
Lee RG. Nonalcoholic steatohepatitis: a study of 49 patients. Hum Pathol 1989; 20: 594-8.
Kojima S, Watanabe N, Numata M et al. Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background. J Gastroenterol 2003; 38: 954-61.
Garaulet M, Perez-Llamas F, Baraza JC et al. Body fat distribution in pre-and post-menopausal women: metabolic and anthropometric variables. J Nutr Health Aging 2002; 6: 123-6.
Saruc M, Yuceyar H, Ayhan S et al. The association of dehydroepi- androsterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women: a hyperinsulinemic euglyce- mic insulin clamp study. Hepatogastroenterology 2003; 50: 771-4.
Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastro- enterol 2003; 98: 960-7.
Mathiesen UL, Franzen LE, Fryden A et al. The clinical significan- ce of slightly to moderately increased liver transaminase values in asymptomatic patients. Scand J Gastroenterol 1999; 34: 85-91.
Noguchi H, Tazawa Y, Nishinomiya F et al. The relationship betwe- en serum transaminase activities and fatty liver in children with simple obesity. Acta Paediatr Jpn 1995; 37: 621-5.
Yano E, Tagawa K, Yamaoka K et al. Test validity of periodic liver function tests in a population of Japanese male bank employees. J Clin Epidemiol 2001; 54: 945-51.
Sonsuz A, Basaranoglu M, Ozbay G. Relationship between aminot- ransferase levels and histopathological findings in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2000; 95: 1370-1.