Vedat GÖRAL, Tahir ÇELENK, Abdurrahman KAPLAN, DEDE ŞİT

Ülseratif kolitli hastalarda plazma sitokin düzeyleri

Giriş ve amaç: Ülseratif kolitin etyopatogenezinden sorumlu faktörlerden birisi de immünolojik faktörlerdir. Sitokinler ile bu hastalık arasında ilişki vardır. Gereç ve yöntem: Bu çalışmada 20 ülseratif kolit vakası (ort. yaş 36.2, 9 kadın, 11 erkek) ve 20 kişilik (ort. yaş 27.2, 11 kadın, 9 erkek) sağlıklı kontrol grubunda; IL-1 beta, IL-2Rsp, IL-6, IL-8, IL-10, TNF-alfa düzeyleri çalışıldı. Bulgular: IL-2Rsp, IL-6, IL-8 ve IL-10 düzeyleri hasta ve kontrol grubunda farklı bulundu (p < 0.005). TNF-alfa ve IL-1 beta seviyeleri her 2 grupta da aynı bulundu. Sonuç: Bu sonuçlara göre, IL-2Rsp, IL-6, IL-8 ve IL-10 ülseratif kolitde rol oynayan önemli sitokinlerdir. Bu sitokinlerin hastalığın, tanı, takip ve prognozunda önemli rol oynacağını düşünmekteyiz.

Anahtar Kelimeler:

Ülseratif kolit, sitokinler

Plasma cytokine levels in ulcerative colitis

Background/aim: Some immunological factors are responsible in the pathogenesis of ulcerative colitis. There are some relationship between cytokines and ulcerative colitis. Materials and method: In this study, the levels of IL-1 beta, IL-2Rsp, IL-6, IL-8, IL-10, TNF-alpha were studied 20 patients with ulcerative colitis (mean age 36.2 years, 9 women, 11 men) and 20 healthy individuals (mean age 27.2 years, 11 women, 9 men). Results: We established that IL-2Rsp, IL-6, IL-8 and IL-10 levels were different in the patients and control groups (p

Keywords:

Ulcerative colitis, cytokines,

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Mendeloff AI, Calkins BM. The epidemiology of idiopathic inflama- tory bowel disease. IN: Kirsner JB, Shorter RG (eds). Inflamatory Bowel Disease, 4th ed. Philadelphia Lea and Febiger 1995, 31-9.
Benett RA, Rubin PH, Present DH. Frequency of inflamatory bowel disease in offspring of couples both presenting with inflamatory bo- wel disease. Gastroenterology 1991, 100 (6),1638-42.
Lindberg E, Tysk C, Anderson K, et al. Smoking and inflamatory bo- wel disease. A case control study. Gut 1988, 29 (3): 352.
Scott MG, Nahm MH, Macke K, et al. Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: Differences between ul- cerative, colitis, Crohn disease and controls. Clin Exp Immunol 1986, 66 (1), 209-13.
Halstensen TS, Mollnes TE, Garred P, et al. Epithelial deposition of immunoglobulin G1 and activated complement (C3b and terminal complement complex) in ulcerative colitis. Gastroenterology 1990, 98 (5 Pt 1): 1264-70.
Boughton-Smith N, Pettipher R: Lipid mediators and cytokines in inflamatory bowel disease. Eur J Gastroenterol Hepatol 1990, 2: 241-5.
Funakoshi K, Sugimura K, Sasakawa T, et al. Study of cytokines in ulcerative colitis. J Gastroenterol 1995, 30 Suppl 8: 61-3.
Guimbaud R, Bertrand V, Chauvelot-Moachon L, Quartier G, et al. Network of inflamatory cytokines and correlation with disease acti- vity in ulcerative colitis. AJG 1998, 93(12): 2397-404.
Melgar S, Yeung MM, Bas A, et al. Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis. J Clin Exp Immunol 2003; 134(1): 127-37.
Murata Y, Ishiguro Y, Itoh J, et al. The role of proinflamatory and immunoregulatory cytokines in the pathogenesis of ulcerative coli- tis. J Gastroenterol 1995, 30 Suppl 8: 56-60.
Funakashi K, Sugimura K, Anezaki, et al. Spectrum of cytokines ge- ne expression in intestinal mucosal lesions of Crohn’s disease and ulcerative colitis. Digestion 1998; 59(1): 73-8.
Masuda H, Iwai S, Tanaka T, et al. Expression of IL-8, TNF-alpha and IFN-gamma m-RNA in ulcerative colitis, particularly in pati- ents with inactive phase. J Clin Lab Immunol 1995; 46(3): 111-23.
Dolar M.E. Ülseratif kolitte serum sitokin düzeyleri: Hastalık akti- vitesi ve akut faz reaktanları ile ilişkileri. Türk J Gastroenterol 1998: 9, 370-73.
Rothkrantz-Kos S, Drent M, Schmitz MP, et al. Reference values of soluble interleukin-2 receptor on the IMMULITE. Clin Chem Lab Med. 2004; 42(8): 976-7.