Sema TUNCER, Naime YALÇIN, Ruhiye REİSLİ, Yosunkaya ALPER

Remifentanile bağlı gelişen postoperatif hiperaljezinin önlenmesinde lornoksikamın etkisi

Amaç: İntraoperatif remifentanil kullanımında akut opioid toleransına bağlı olarak postoperatif ağrı, opioid tüketimi ve insizyon çevresinde hiperaljezi artmaktadır. Bu çalışmada amacımız, remifentanile bağlı gelişen postoperatif hiperaljezinin önlenmesinde lornoksikamın etkiliğini değerlendirmektir. Gereç ve Yöntem: Olgular randomize olarak iki gruba ayrıldı. Cerrahi başlamadan 15 dk önce Grup I’e (n=22, kontrol) serum fizyolojik, Grup II’ye (n=20, lornoksikam) 16 mg lornoksikam i.v uygulandı. Anestezi indüksiyonu 1 µg/kg remifentanil, 1.5-2 mg/kg propofol, idamesi 0.5 minimum alveolar konsantrasyon (MAC) desfluran ve 0.4 µg/kg/dk remifentanil ile sağlandı. Desfluran konsantrasyonu otonomik cevaplara göre titre edildi. Bütün olgulara cerrahi sonlanmadan 30 dk önce 0.15 mg/kg morfin i.v verildi. Cerrahinin sonunda olgulara i.v hasta kontrollü analjezi cihazı ile morfin uygulandı. Ağrı skoru, morfin isteği ve sunumu postoperatif 2., 4., 6., 12. ve 24. saatlerde değerlendirildi. Total morfin tüketimi 24. ve 48. saatte kaydedildi. Periinsizyonel hiperaljezi operasyon öncesi ve postoperatif 24. ve 48. saat algometre ile ağrı eşiği ölçülerek değerlendirildi. Bulgular: Ağrı skorları ve toplam morfin tüketimi lornoksikam grubunda kontrol grubuna göre daha düşük bulundu (p

The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia

Objectives: Intraoperative remifentanil administration results in acute opioid tolerance that is manifested by increased postoperative pain, opioid requirement and specifically peri-incisional hyperalgesia. The aim of this study was to investigate the effect of lornoxicam in preventing remifentanil-induced hyperalgesia. Methods: Patients were randomly divided into two groups. Fifteen minutes before surgery, saline solution was given to the patients in group I and 16 mg i.v. lornoxicam in group II. Anesthesia was induced with 1 µg/kg remifentanil combined with 1.5-2 mg/kg propofol and maintained with 0.5 MAC desflurane and 0.4 µg/kg/dk remifentanil in both groups. Desflurane concentration was titrated according to autonomic responses. All patients were given i.v. 0.15 mg/kg morphine 30 min before the end of surgery. At the end of surgery, patients received morphine i.v. via a PCA (Patient Controlled Analgesia) device. Pain score, morphine demand and delivery were assessed at 2, 4, 6, 12 and 24 h after surgery. Total morphine consumption was recorded for 24-48 h. Peri-incisional hyperalgesia was assessed by measuring pain threshold to pressure using an algometer before operation and at 24-48 h postoperatively. Results: The pain scores and cumulative morphine consumption were significantly lower in the lornoxicam group when compared with the control group (p<0.05). Pain thresholds were significantly less at 24-48 h postoperatively in the control group than in the lornoxicam group. No significant difference was observed in side effects (p>0.05). Conclusion: Lornoxicam administered preemptively prevented remifentanil-induced hyperalgesia.

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