Işık ALPER, Sezgin ULUKAYA, Volkan ERTUĞRUL, Özer MAKAY, Meltem UYAR, Taner BALCIOĞLU

Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: A prospective, randomized, double-blinded study

Amaç: İntraperitoneal levobupivakain uygulamasının laparoskopik kolesistektomi sonrası ağrı üzerine etkisinin randomize, çift kör, plasebo-kontrollü çalışma olarak araştırılması amaçlandı. Gereç ve Yöntem: Tüm hastalara trokar giriş yerlerine levobupivakain %0.25’lik (toplam 15 mL) infiltrasyonu ile birlikte, pnömoperiton sonrası, randomizasyon şemasına göre, intraperitoneal olarak hepatodiyafragmatik alana ve safra kesesi üst lojuna toplam 40 mL %0.25’lik levobupivakain (Grup LB, n=20) veya 40 mL normal salin (Grup NS, n=20) uygulandı. İki grubun intraoperatif özellikleri, postoperatif ağrı durumu ve ek analjezik gereksinimi, yan etkiler ve hasta memnuniyeti ilk 24 saatlik dönemde karşılaştırıldı. Bulgular: Postoperatif ağrı skoru, postoperatif ilk 30. dk’da, Grup LB’de Grup NS’ye göre anlamlı olarak daha düşüktü (p

İntraperitoneal levobupivakain uygulamasının laparoskopik kolesistektomi sonrası ağrı üzerine etkisi: Prospektif, randomize, çift-kör çalışma

Objectives: We aimed to determine the effects of intraperitoneal administration of levobupivacaine on pain after laparoscopic cholecystectomy in a prospective, randomized, double-blinded, placebo-controlled trial. Methods: In all patients, infiltration of levobupivacaine 0.25% (15 mL) was used prior to skin incisions for trocar insertion. After pneumoperitoneum was achieved, patients were allocated randomly to receive intraperitoneally either 40 mL of 0.25% levobupivacaine (LB group, n=20) or normal saline (NS group, n=20) under direct vision into the hepatodiaphragmatic lodge and above the gallbladder. Data of intraoperative variables, postoperative pain relief, rescue analgesic consumption, side effects, and patient satisfaction were followed in both groups. Results: The postoperative pain scores were significantly lower in the first half-hour period in the LB group than in the NS group (p<0.05). However, the incidence of right shoulder pain was not significantly different between the LB group (10%) and NS group (15%). The mean dose of meperidine consumption and the number of patients needing rescue meperidine were significantly lower in the LB group than in the NS group (p<0.05). Significantly lower vomiting incidence and increased patient satisfaction were determined in the LB group compared to the NS group (p<0.05). Conclusion: Intraperitoneal administration of 40 mL levobupivacaine 0.25% given immediately after pneumoperitoneum into the hepatodiaphragmatic lodge and above the gallbladder demonstrated useful effects on postoperative pain relief after laparoscopic cholecystectomy, especially in the early postoperative period, and reduced postoperative rescue analgesic requirement, with excellent patient satisfaction. There were no LB-related complications or side effects.

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