İsmail Kerem GELİR, MEHMET SACİT GÜLEÇ, Dilek CEYHAN

Postoperatif ağrıda deksketoprofenin preventif etkisi

Amaç: Preventif analjezi ağrılı stimulusların preoperatif, intraoperatif ve postoperatif dönemde azaltılması olarak tanımlanır. Bu çalışmanın amacı tüm ameliyat boyunca uygulanan ketamin ile santral sensitizasyonu engelleyerek insizyon öncesi ve sonrası uygulanan deksketoprofen trometamolün preventif etkisini değerlendirmektir.Gereç ve Yöntem: Bu çalışma 50 hasta üzerinde yapıldı. Grup I e cerrahi insizyondan önce 50 mg deksketoprofen trometamol, Grup II e cerrahi insizyondan 10 dakika sonra aynı miktarda deksketoprofen trometamol verildi. Genel anestezi indüksiyonunu takiben tüm hastalara 0.50 mg kg-1 ketamine bolus yapıldı ve sonrasında 0,07 mg kg-1 h-1 infüzyon şeklinde ketamin verildi.Bulgular: Her iki gruptaki Vizuel Analog Skala değerleri karşılaştırıldığında, Grup I de 1. ve 4. deki Vizuel Analog Skala değerleri Grup II ye göre anlamlı ölçüde düşüktü. Ek olarak morfin tüketimi 4,8,12 ve 24.saatlerde Grup I de Grup II ye göre anlamlı düşüktü.Sonuç: Santral sensitizasyonu önlemek için ketamin ile birlikte insizyon öncesi uygulanan deksketoprofen insizyon sonrası uygulama ile karşılaştırıldığında daha düşük morfin tüketimi ve daha efektif analjezi sağlar.

Preventive effect of dexketoprofen on postoperative pain

Objectives: Preventive analgesia has been defined as reduction in noxious stimuli during preoperative, intraoperative, and postoperative periods. The aim of the present study was to prevent central sensitization by administering ketamine infusion throughout the surgical procedure. In addition, possible preventive effects of dexketoprofen when administered before and after incision were evaluated.Methods: Fifty patients were included. Group I was administered 50 mg intravenous dexketoprofen prior to surgical incision, and Group II received the same amount 10 minutes after the incision had been made. Following induction of general anesthesia, all patients received a bolus of 0.50 mg/kg ketamine in 0.07 mg/kg/h intravenous infusion.Results: When postoperative visual analog scale values were compared, values for Group I after 1 and 4 hours were significantly lower than those of Group II. In addition, morphine consumption at 4, 8, 12, and 24 hours was significantly lower in Group I.Conclusion: Combined with the prevention of central sensitization with ketamine, administration of dexketoprofen prior to incision led to a lower rate of morphine consumption and more effective analgesia than post-incision administration.

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