SİBEL GÜLER, Selçuk YAVUZ, Engin NAKUŞ, Yüce DOĞRU

Gabapentin tedavisine belirgin yanıt alınan ağrılı ayaklar ve hareketli parmaklar sendromu

Elli sekiz yaşında kadın hasta iki yıl önce başlayan her iki alt ektremitede ağrı ve ayak parmaklarında belirgin istemsiz hareketler yakınmaları ile değerlendirildi. Nörolojik muayenesinde bilateral alt ekstremite parmaklarında hastanın istemli olarak durdurabildiği fleksiyon/ekstansiyon, abduksiyon/addüksiyon şeklinde gözlenen kıvrılma hareketleri dışında özellik saptanmadı. Etyolojisine yönelik incelemelerde lomber vertebra MRG'sinde L3-4 ve L4-5 diskinde dural keseye ve nöral elemanlara kısmi bası oluşturan posterior anüler taşma saptandı. Elektromiyografide sağ EDB kasından 200 mV ve 1 Hz frekansta yapılan incelemede semiritmik tekrarlayıcı hareketler saptandı. Hastaya 1200 mg/gün gabapentin tedavisi kademeli arttırılarak başlandı. Tedavi sonrasında ağrıları, ayakları ve ayak parmaklarında saptanan istemsiz hareketlerde belirgin gerileme izlendi. PMLT tedavisinde GABA'erjik ajanlar son derece etkilidir. Burada nadir olarak gözlenmesi sebebiyle klinik ve elektrofizyolojik bulgular ile ağrılı ayaklar ve hareketli parmaklar sendromu olarak tanımlanan bir olgu sunuma değer bulunmuştur.

A case of painful legs and moving toes syndrome treated with gabapentin

A 58-year-old woman was evaluated following complaints of pain in both lower extremities and brief involuntary movements in her toes, which had begun 2 years prior. No signs were present beyond a curling, flexion/extension, abduction/adduction movement in the toes of both lower extremities, voluntarily stoppable during neurologic examination. During investigation into etiology, lumbar vertebrae MRI revealed a posterior annular protrusion causing partial compression of the dural sac and neural elements by the L3-4 and L4-5 discs. Semirhythmic repetitious movements were detected on electromyography performed on right extensor digitorum brevis (EDB) muscle with 200 mV and 1 Hz frequency. Patient was put on a gradually increased dose of gabapentin, starting at 1200 mg/day. A brief regression in pain and involuntary movements in feet and toes was observed. GABAergic agents are very effective treatment of painful legs and moving toes syndrome. The present clinically and electrophysiologically diagnosed case was considered worth reporting, as painful legs and moving toes syndrome is a very rare condition.

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