Yeni 5,8-Dibromo-2-O/S-sübstitüe-1,4-naftakinon Türevlerinin Sentezi ve Antimikrobiyal Aktivitelerinin Değerlendirilmesi

2,5,8-Tribromo-l,4-naftokinon’dan (1) nükleofilik sübstitüsyon reaksiyonları ile yeni bromo- ve O/S- sübstitüe-1,4-naftokininon (3a-3i) türevleri sentezlendi. Yeni sentezlenen türevlerin antimikrobiyal olarak incelenmesi agar spot yöntemi kullanılarak gerçekleştirildi. Bileşik 3a, 3b ve 3c sırasıyla P. vulgaris, B. cereus ve B.subutilis, ve B.cereus'a karşı 61,25 ug/mL’lik MIC değeri ile en büyük aktivite sergiledi. Sonuçlar, bileşik 3c'nin test edilen tüm mikroorganizmalara karşı belirgin etkinliğe sahip olduğunu ortaya koymuştur.

Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S- substituted-1,4-naphthoquinone Derivatives

Novel bromo- and O/S-substituted-1,4-naphthoquninones (3a-3i) were synthesized via nucleophilicsubstitution reactions from 2,5,8-tribromo-1,4-naphthoquinone (1). Antimicrobial evaluation of thenewly synthesized derivatives was performed using agar spot method. Compounds 3a, 3b, and 3cexhibited the greatest activity with MIC value of 61,25 μg/mL against P. vulgaris, B. cereus andB.subutilis, and B.cereus, respectively. Results revealed that compound 3c has notable activity againstall tested microorganisms.

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