Blefaroptozis etyolojisinin adli tıp açısından değerlendirilmesi

Ptozisin çok çeşitli nedenleri vardır. Adli rapor düzenlenme den önce ptozis nedenini tespit etmek önemlidir. Özellikle işkence mağdurları gibi bazı travmatik olgular akut dönemde çeşitli nedenlerden dolayı sağlık kuruluşlarına başvurmamaktadırlar. Bazen de sağlık çalışanlarının ihmaline bağlı olarak akut dönemde başvuru yapılan sağlık kuruluşunda olaya dair rapor tutulmamaktadır. Travmadan sonra geç başvuru yapan olgularda cilt bulguları azaldığından veya tamamen kaybolduğundan dolayı ptozisin nedenini ortaya koyma açısından Göz Hastalıkları ve Adli Tıp Uzmanları olabildiğince güç durumda kalabilmektedirler. Kronik ptozis olgusu ile karşılaşan bir doktor her şeyden önce olaya ciddiyetle yaklaşmalıdır. Etyolojik nedenlerin oldukça geniş bir yelpaze içinde bulunması ayırıcı tanıyı yapmayı güçleştirmektedir. Tanı koyma aşamasında yaşanan sorunların ana nedeni ise, anamnezin iyi alınmayışı veya ciltteki lezyonun iyileşmesi bazen skar dokusunun dahi tespit edilemeyişidir. Tanı yöntemleri işi aceleye getirmeden büyük bir sabır ve ciddiyetle uygulanmalı ve ptozisin, kişinin aşadığı olayla nedensellik bağı kurulmalıdır.

The evaluation of blepharoptosis etiology from the point of forensic medicine

There are several reasons for ptosis. It is important to determine the cause of ptosis before writing the forensic report. In some traumatic cases, victims, especially victims of torture, do not apply to health care providers for some reasons. Sometimes, healthcare provider institution, to which victims apply during the acute phase, does not keep an incident report due to the negligence of health professionals. The skin findings in patients who apply late after the trauma go down or completely disappear. Because of that, optometrists and forensic science experts have difficulty to determine the cause of ptosis. A doctor faced with a chronic case of ptosis must treat the event seriously. The presence of a wide range of etiological factors makes it difficult to make the differential diagnosis. The main reason for the problems in the diagnostic phase is anamnesis not taken properly or healing of skin lesions; sometimes even the scar tissue can not be found. Diagnostic methods should be performed patiently and carefully without rushing and causality should be established between the event and the victim.

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  • 1. Çiftçi Ö.F. Ptoziste Ayırıcı Tanı ve Cerrahi Yöntem Seçimi. Turkiye Klinikleri J Surg Med Sci 2007;3(25):34-41.
  • 2. Duman S. Oküloplasti. Yalaz M, editör. Göz Kapağı Şekil Bozuklukları. 1.Baskı. Bursa: Türk Oftalmoloji Derneği Eğitim Yayınları No:1; 2003.
  • 3. Finsterer J. Ptosis: causes, presentation and management. Aesthetic Plast Surg. 2003;27(3):193-204.
  • 4. Duman S. Oküloplasti. Argın A, editör. Göz Kapağı Anatomisi. 1.Baskı. Bursa: Türk Oftalmoloji Derneği Eğitim Yayınları No:1; 2003.
  • 5. Zorab RA, Straus H, Dondrea CL, Arturo C, Modric R, Tanaka S, Loftus K. Fundamentals and Principles of Ophthalmology. Orbit and Ocular Adnexa. Section 2. American Academy of Ophthalmology. 2005-2006.
  • 6. Gutierrez JC, Zamora FM, Quinones SM, Bertomeu JP, Ginebreda JA. Congenital mygenic blepharoptosis: indications of treatment and results of 50 cases. Cir. Pediatr. 2008;21(4):214-218.
  • 7. Su YH, Ong CT. Marcus Gunn jawwinking syndrome. Acta Neurol Taiwan. 2010;19(1):76-7.
  • 8. Park KP, Kim HS, Kim ES, Park YE, Lee CH, Kim DS. SLC25A4 and C10ORF2 mutations in autosomal dominant progressive external ophthalmoplegia. J Clin Neurol. 2011;7(1):25-30.
  • 9. Brais B. Oculopharyngeal muscular dystrophy. Handb. Clin. Neurol. 2011;101:181-92.
  • 10. Nadai-Pakleza A, Lusakowska A, Sulek-Piatkowska A, Krysa W, Rajkiewicz M, Kwiecinski H, Kaminska A. Muscle pathology in myotonic dystrophy: light and electron microscopic investigation in eighteen patients. Folia Morphol (Warsz.). 2011;70(2):121-9.
  • 11. Mercelis R, Merckaert V. Diagnostic utility of stimulated single-fiber electromyography of the orbicularis oculi muscle in patients with suspected ocular myasthenia. Muscle Nerve. 2011;43(2):168-70.
  • 12. Kanzaki A, Motomura M. A pregnant patient with anti-Mu-SK antibody positive myasthenia gravis and her infant with transient neonatal myasthenia gravis. Rinsho Shinkeiqaku.2011;51(3):188-91.
  • 13. Sanke RF. Relationship of senile ptosis to age. Ann. Ophthalmol. 1984;16(10):928-31.
  • 14. Dinh Doan G, Noel D, Chassagne JF, Rodier C. Traumatic rupture of the levator tendon of the upper eyelid. Rey Stomatol Chir Maxillo fac. 1992;93(3):154-7.
  • 15. Baggio E, Ruban JM. Postoperative ptozis: etiopathogenesis, clinical analysis and therapeutic management. Apropos of a series of 43 cases. J Fr Ophtalmol. 1998;21(5):361-73.
  • 16. Sanke RF. Blepharoptosis as a complication of pregnancy. Ann Ophthalmol. 1984;1688):720-2.
  • 17. Fujiwara T, Matsuo K, Kondoh S, Yuzuriha S. Etiology and pathogenesis of aponeurotic blepharoptosis. Ann Plast Surg. 2001;46(1):29-35.
  • 18. Griffin RY, Sarici A, Unal M. Acguired ptosis secondary to vernal conjunctivitis in young adults. Ophtal Plast Reconstr Surg. 2006;22(6):438-440.
  • 19. Koursh DM, Modjtahedi SP, Selva D, Leibovitch I. The blepharochalasis syndrome. Surv Ophthalmol. 2009;54(2):235-44.
  • 20. Hartel P. Plastic surgery treatment of blepharochalasia with ptosis. Langenbecks Arch Chir Suppl Kongressbd. 1996;113:1115-7.
  • 21. Klingele J, Kaiser HJ, Hatt M. Automated perimetry in ptosis and blepharochalasis. Klin Monbl Augenheikd. 1995;206(5):401-4.
  • 22. Jordan DR, Anderson RL. The aponeurotic approach to congenital ptosis. Ophthalmic Surg. 1990;21(4):237-44.
  • 23. Song A, Carter KD, Nerad JA, Boldt C, Folk J. Steroid-induced ptosis: case studies and histopathologic analysis. Eye (Lond). 2008;22(4):491-5.
  • 24. Viola F, Morescalchi F, Ratiglia R, Staurenghi G. Ptosis following an intravitreal injection of triamcinolone acetonide. Eye (Lond). 2007;21(3):421-3.
  • 25. Dal Canto AJ, Downs-Kelly E, Perry JD. Ptosis and orbital fat prolapse after posterior sub-Tenon’s capsule triamcinolone injection. Ophtalmology. 2005;112(6):1092-7.
  • 26. Watanable A, Araki B, Noso K, Kakizaki H, Kinoshita S. Histopathology of blepharoptosis induced by prolonged hard contact lens wear. Am J Ophthalmol. 2006;141(6):1092-6.
  • 27. McCulley TJ, Kersten RC, Yip CC, Kulvin DR. Isolated unilateral neurogenic blepharoptosis secondary to eyelid trauma. Am J Ophthalmol. 2002;134(4):626-7.
  • 28. Waller PY, Chossegros C, Semeria E, Gola R. Post-traumatic ptosis. Rey Stomatol Chir Maxillo fac. 1991;92(4):237-46.
  • 29. Keane JR. Ptosis and levator paralysis caused by orbital roof fractures. Three cases with subfrontal epidural hematomas. J Clin Neuroophthalmol. 1993;13(4):225-8.
  • 30. Xum M, Qi M, Zhou H, Yong J, Qiu H, Cong P, Hong X, Li C, Jiang Y, Chen X, Yu Y. Familial syndrome resembling Aarskog syndrome. Am J Med Genet A. 2010;152(8):2017-22.
  • 31. Visootsak J, Rosner B, Dykens E, Schwartz C, Hahn K, White SM, Szeftel R, Graham JM. Clinical and behavioral features of patients with Borjeson-Forssman Lehmann syndrome with mutatioans in PHF6. J Pediatr. 2004;145(6):819-25.
  • 32. Sudarshan R, Anniqeri RG. Lenz Microphthalmia Syndrome?. Wien Klin Wochenschr. 2011;123(3-4):78.
  • 33. Romano AA, Allanson JE, Dahlgren J, Gelb BD, Hall B, Pierpont ME, Roberts AE, Robinson W, Takemoto CM, Noonan JA. Noonan syndrome: clinical features, diagnosis and management guidelines. Pediatrics. 2010;126(4): 746-59.
  • 34. Cooymans P, Al-Zuhaibi S, AlSenawi R, Ganesh A. Congenital fibrosis of extraocular muscles. Oman J Ophthalmol. 2010;3(2):70-4.
  • 35- Anqsanuntsukh C, Oto M, Holmes L, Roqers KJ, Kinq MM, Donohoe M, Kumar SJ. Congenital vertical talus in multiple pterygium syndrome. J Pediatr Orthop. 2011;31(5):564-9.
  • 36. Hirayama T, Kobayashi T, Fujita T, Fujino O. A case of severe mental retardation with blepharophimosis, ptosis, microphthalmia, microcephalus, hypogonadism, and short stature-the difference from Ohdo blepharophimosis syndrome. No To Hattatsu. 2004;36(3):253-7.
  • 37. Pena WA, Slavotinek A, Oberoi S. Saethre-Chotzen syndrome: a case report. Cleft Palate Craniofac J. 2010;47(3):318-21.
  • 38. Schulze BR, Horn D, Kobelt A, Tariverdian G, Stelziq A. Rare dental abnormalities seen in oculo-facio-cardio-den-tal (OFCD) syndrome:three new cases and review of nine patients. Am J Med Genet. 1999;82(5):429-35.
  • 39. Goadsby PJ. Raeder’s syndrome[corrected]. paratrigeminal paralysis of the oculopupillary sympat-hetic system. J Neurol Neurosurg Psychiathry. 2002;72(3):297-9.
  • 40. Tidyman WE, Lee HS, Rauen KA. Skeletal muscle pathology in costello and cardio-facio-cutaneus syndromes: developmental consequences of germline Ras/MAPK activation on myogenesis. Am J Med Genet C Semin Med Genet. 2011;157(2):104-14.
  • 41. Taban M, Cohen BH, David Rothner A, Traboulsi EI. Association of optic nerve hypoplasia with mitochondrial cytopat-hies. J Child Neurol. 2006;21(11):956-60.
  • 42. Brunnerova R, Lebl J, Krasny J, Pruhova S. Ocular manifestations in Turner’s syndrome. Cesk Slov Oftalmol. 2007;63(3):176-84.
  • 43. Wygnanski-Jaffe T, Shin J, Perruza E, Abdolell M, Jackson LG, Levin AV. Ophthalmologic findings in the Cornelia de Lange Syndrome. J AAPOS. 2005;9(5):407-15.
  • 44. Pfeiffer KJ, Ropers SK, Short MW. Diplopia and ptosis. Diagnosis: Diabetic third nerve palsy. Am Fam Physician. 2010;82(2):187-8.
  • 45. Haddad HM. Management of surgical overcorrection of ptosis with topical quanethidine sulfate: a case report. Metab Pediatr Syst Ophthalmol. 1982;6(3-4):285-6.
  • 46. Thapa R, Karmacharya PC, Nepal BP. Etiological pattern of blepharoptosis among patients presenting in teaching hospital. JNMA J Nepal Med Assoc. 2006,45(162):218-22.