Nöroblastom çocukluk ça¤›n›n en s›k rastlanan ekstrakraniyal solid tümörü olmakla birlikte özellikle 5 yafl alt› çocuklarda kemik metastazlar› ve buna ba¤l› patolojik k›r›klar›n ay›r›c› tan›s›nda ak›lda bulundu- rulmal›d›r. Çal›flmam›zda, patolojik femur k›r›¤›yla baflvuran ve metastatik nöroblastom tan›s› konulan 11 ayl›k bir k›z olgu sunuyoruz.
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1. Young JL Jr, Ries LG, Silverberg E, Horm JW, Miller RW. Cancer incidence, survival, and mortality for children younger than age 15 years. Cancer 1986;58:598-602.
2. Himelstein BP, Dormans JP. Malignant bone tumors of childhood. Pediatr Clin North Am 1996;43:967-84.
3. Gedalia A, Kassis I. Articular involvement as a presenting symptom of malignancy in childhood. [Article in Hebrew] Harefuah 1989;117:61-4.
4. Wheeler DS, Starr SR. Case 2. Neuroblastoma as a cause of opsoclonus. Pediatr Rev 1998;19:281-3.
5. Alexander F. Neuroblastoma. Urol Clin North Am 2000;27: 383-92.
6. Applegate K, Connolly LP, Treves ST. Neuroblastoma pre- senting clinically as hip osteomyelitis: a “signature” diagno- sis on skeletal scintigraphy. Pediatr Radiol 1995;25:S93-6.
7. Aston JW Jr. Pediatric update #16. The orthopaedic presen- tation of neuroblastoma. Orthop Rev 1990;19:929-32.
8. Olgun N, Günefl D, Aksoylar S, Varan A, Erbay A, Hazar V, et al. On behalf of TSPO. 14th Turkish Society of Pediatric Oncology National Pediatric Cancer Congress. May 18-20, 2006; Abstract Book.
9. Hero B, Simon T, Horz S, Berthold F. Metastatic neurob- lastoma in infancy: what does the pattern of metastases con- tribute to prognosis. Med Pediatr Oncol 2000;35:683-7.
10. Kaufman RA, Thrall JH, Keyes JW Jr, Brown ML, Zakem JF. False negative bone scans in neuroblastoma metastatic to the ends of long bones. AJR Am J Roentgenol 1978;130:131-5.
11. Brodeur GM, Castleberry RP. Neuroblastoma. In: Pizzo P, Poplack DG, editors. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott-Raven,1997. p. 761.
12. Lanzkowsky P. Neuroblastoma. In Manuel of Pediatric Hematology and Oncology. California: Academic Press, 1999. p. 493.
13. Cotterill SJ, Pearson AD, Pritchard J, Foot AB, Roald B, Kohler JA, et al. Clinical prognostic factors in 1277 patients with neuroblastoma: results of the European Neuroblastoma Study Group ‘survey’ 1982-1992. Eur J Cancer 2000;36:901- 8.
14. Cheung NK, Kushner BH, LaQuaglia M, Kramer K, Gollamudi S, Heller G, et al. N7: a novel multi-modality ther- apy of high risk neuroblastoma (NB) in children diagnosed over 1 year of age. Med Pediatr Oncol 2001;36:227-30.