Mide ve Kolorektal Kanser ile Serum Gama Glutamil Transferaz Düzeyleri Arasındaki İlişkinin İncelenmesi

Kanser, son yıllarda insidansı ve mortalitesi hızla artan bir hastalıktır. Yapılan çalışmalarda GGT artışı ile kanser riski arasında doğru orantılı bir korelasyon olduğu gözlenmiştir. Bu durum GGT'nin klinik rolü üzerine yoğunlaşılması gerektiğini düşündürmektedir. Bu nedenle bu çalışmada mide ve kolorektal kanserli hastaların GGT düzeylerinde anlamlı bir ilişki olup olmadığı değerlendirilmiştir. Sanko Üniversitesi Hastanesi İç Hastalıkları A.B.D. Gastroenteroloji kliniğinde tanısı histopatolojik olarak doğrulanmış mide ve kolorektal kanser hastalarının dosyaları taranmıştır. Çalışmaya mide ve kolorektal tanısı almış ve kemoterapi almamış olan 90 hasta dahil edilmiştir. Grup karşılaştırmalarında; ölçümle belirtilen sürekli değişkenler için parametrik test koşullarının sağlanması durumunda iki ortalama arasındaki farkın önemlilik testi veya tek yönlü ANOVA, parametrik test koşullarının sağlanmadığı durumlarda Mann-Whitney U testi veya Kruskal-Wallis testi kullanıldı. Nitel değişkenlerin grup karşılaştırmaları için ki-kare testi kullanıldı. p

Anahtar Kelimeler:

Karsinogenez, GGT, Mide kanseri, kolorektal kanser

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