Sevgiye KAÇAR ÖZKARA, Cengiz ERÇİN, Bahar MÜEZZİNOĞLU, Neşet Nuri GÖNÜLLÜ, Bekir ERALDEMİR, Tuncer ÖCALAN

Malign Fibröz Histiositom

Malign fibröz histiositom, yedinci dekad civarında en sıklıkla görülen yumuşak doku sarkomudur. Genellikle alt ekstremitelerde ve kas içerisinde derin yerleşimli olan bu tümor, 4 histopatolojik tipte görülür. (Görülme sıklığına göre, storiform-pleomorfik, mikzoid, dev hücreli ve inflamatuvar tipler.) Bu sunumda biri aksilla, diğeri ise üst ekstremitede subkutan yerleşimli, ilki storiform-pleomorfik, ikincisi ise dev hücreli tipte iki malign fibröz histiositom olgusu yer almaktadır. Hastalardan ilki 67, ikincisi ise 71 yaşında olup, her ikisi de erkektir.

Anahtar Kelimeler:

Malign fibröz histiositom (MFH), storiform-pleomorfik, dev hücreli

Malignant Fibrous Histiocytoma

Malignant fibrous histiocytoma is the mostly encountered soft tissue sarcoma around the seventh decade of life. Usually, it is located at lower ekstremities and deep in the muscles. It is seen in 4 histopathological subtypes, namely storiform pleomorphic, myxoid, giant cell and inflammatory types respectively. At this presentation, there are two malignant fibrous histiocytoma cases, one of storiform-pleomorphic and the other of giant cell types; the first located at the axillary region and the second located at the upper extremity subcutaneously. The first patient is 67 years of age and the second one is 71, both being males.

Keywords:

Malignant fibrous histiocytoma (MFH), storiform-pleomorphic, giant cell,

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Enzinger FM, Weis SW. Soft Tissue Tumors. 3rd Edition. St. Louis: Mosby-Year Book Inc; 1995:351-380.
Rosai J. Ackerman's Surgical Pathology ,8th Edition(Vol2). St. Louis: Mosby-Year Book Inc; 1996:2036-2041.
Cotran RS, Kumar V, Robbins SL. In: Schoen FJ, ed. Pathologic Basis of Disease. 5th Edition. Philadelphia: W.B. Saunders; 1994:1267.
Hollowood K, Fletcher CD. Malignant fibrous histiocytoma:morphologic pattern or pathologic entity? Semin Diagn Pathol. 1995;12(3):210-220.
Takeya M, Yamasiro S, Yoshimura T, Takahashi K. lmmunophenotypic and immunoelectron microscopic charaterzation of major constituent cells in malignant fibrous histiocytoma using human cell lines and their transplanted tumors in immunodeficient mice. Lab Invest. 1995;72(6):679-688.
Menztel T, Fletcher CD. Malignant mesenchymomas of soft tissue associated with numerous osteoclast-like giant cells mimicking the so called giant celt variant of "malignant fibrous histioscytoma" Virchows Arch. 1994;424(5):539-545. doi:10.1007/bf00191441