Ömer Aydın YILDIRIM, Necla BENLİER, Hülya ÇİÇEK, Hüseyin GÜRBÜZ, Nuri ORHAN, Özlem Nuray SEVER, Mustafa YILDIRIM

BAKTERİYEL SEPSİSTE HIGH MOBILITY GROUP BOX PROTEIN-1’İN ROLÜ

Amaç: Sepsis ve ilişkili bozulmuş inflamatuar yanıt, çoklu organ disfonksiyonuna ve sonunda ölüme yol açabilir. HMGB1, nekrotik hücreler tarafından pasif olarak salınır ve inflamatuar hücreler tarafından aktif olarak salgılanır ve hücre dışı bir sinyal molekülü görevi görür. Bu çalışmanın amacı, sepsis tanısı alan hastalar ile sağlıklı kontroller arasında serum HMGB1 düzeylerini karşılaştırmaktır. Yöntem: Çalışmaya Gaziantep Medical Park Hastanesi Yoğun Bakım Ünitesinde 2018-2019 yılları arasında tedavi gören sepsisli hastalar ile aynı hastanenin dahiliye polikliniğine rutin kontrol için başvuran herhangi bir hastalığı olmayan sağlıklı bireyler alındı. Hastalardan (tedavinin başlangıcından hemen önce) ve kontrol deneklerinde HMGB1 seviyeleri Bio-Techne kitleri (NBP2-62766) kullanılarak nicel olarak belirlendi. Tüm istatistiksel analizler SPSS for Windows 15.0 yazılım paketi kullanılarak yapıldı. Bulgular: Araştırmanın örneklemini 36 hasta (14 (%38,9) kadın ve 22 (%61,1) erkek) ve 35 sağlıklı gönüllü olmak üzere toplam 71 katılımcı oluşturmuştur. Hastaların yaş ortalaması 70,97±14,72 yıl (dağılım 43-91) idi. HMGB1 değişkeni normal bir dağılım izlemediğinden, hasta ve kontrol grupları arasındaki fark Mann-Whitney U testi kullanılarak analiz edildi ve bu fark istatistiksel olarak anlamlı bir grup arası fark ortaya koydu (p

Anahtar Kelimeler:

Sepsis, Bakteriyel Sepsis, High Mobility Group Box 1 protein (HMGB1), Enflamasyon, Sepsis İlişkili Organ Yetmezliği Değerlendirmesi

The evolution of autism: A bibliometric analysis

Background: In parallel with the dramatic increase in the autism prevalence, a large number of articles has been published in recent years. The main aim of our study was to make descriptive and evaluative analysis of autism related publications using bibliometric mapping and provide better understanding of autism. To make the bibliometric analysis of autism literature, all studies published from 1980 to 2020 on autism were selected from Web of Science. Density and network visualization maps according to certain bibliometric indicators (country, source, and keywords) were obtained with VOSviewer software. Results: From 1980 to 2020, 59653 studies on autism were retrieved. The journal publishing the most studies on this subject is Journal of Autism and Developmental Disorders. The countries having the highest number of publications were USA (46.31%), England (11.39%) and Canada (6.02%). The top 3 organization that published most articles about autism were University of California System (3623), University of London (2671) and Harvard University (1663). Conclusion: Studies on autism were on the rise worldwide, especially in the USA. They published in different fields and in many different sources. What needs to be done here is to increase cooperation in work with autism.

Keywords:

Autism, ASD, Biblometric Analysis, VOSviewer,

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