Anti-Kanser Etkiler Işığında D Vitamini ve Kanser

İnsan beslenmesinde büyük öneme sahip olan vitaminler vücutta önemli mekanizmalarda yer almaktadır. Bu vitaminler arasında, D vitamininin önemi giderek artmaktadır. Neredeyse tamamen güneş ışınları ile deride sentez edilen D vitamininin vücutta birçok görevi vardır. Birçok çalışmada kemik yapısı ile ilişkilendirilse de D vitamininin prevelansı ve türleri gittikçe yaygınlaşan kanser ile ilişkileri üzerinde durulmaktadır. Bu derlemede çeşitli antikanser etkilere sahip olan D vitamininin mekanizmaları ve kanser ile arasındaki ilişkilerden bahsedilecektir

In The Light of The Anti-Cancer Effects of Vitamin D On Cancer

Vitamins play an important role in human nutrition and are part of the important mechanisms in the body. Among these vitamins, vitamin D has become known to be increasingly important. Almost completely synthesized in the skin by sunlight, vitamin D has many functions in the body. In this literature review, the relationship between cancer and the mechanism of vitamin D having various anti-cancer effects, will be reviewed

Keywords:

vitamin D, cancer, apoptosis anticancer,

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Park S, Ham JO, Lee BK. A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men. Clin Nutr 2014;33:900–5.

Clinckspoor I, Verlinden L, Mathieu C, Bouillon R, Verstuyf A, Decallonne B. Vitamin D in thyroid tumorigenesis and development. Prog Histochem Cytochem 2013;48:65–98.

Chiang KC, Chen TC. The Anti-cancer Actions of Vitamin D. Anti- Cancer Agents in Medicinal Chemistry 2013;13:126-39.

Baysal A. Beslenme. Ayşe Baysal, 14. baskı, Ankara, Hatipoğlu Yayınları 2012:176-83.

Zerwekh JE. Blood biomarkers of vitamin D status. Am J Clin Nutr 2008;87:1087-91.

Wesa KM, Segal NH, Cronin AM, Sjoberg DD, Jacobs GN, Coleton MI et al. Serum 25-Hydroxy Vitamin D and Survival in Advanced Colorectal Cancer: A Retrospective Analysis. Nutrition and Cancer 2015;67:424–30.

Bikle D. Nonclassic Actions of Vitamin D. J Clin Endocrinol Metab 2009; 94:26–34.

Salle BL, Delvin EE, Lapillonne A, Bishop NJ, Glorieux FH. Perinatal metabolism of vitamin D. Am J Clin Nutr 2000;71:1317–24.

Pearce SHS, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ 2010;340:142-7.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global Cancer Statistics-2012. CA Cancer J Clin 2015;65:87-108.

Vieneis P. Definition and classification of caner: monothetic or polythetic? Theoretical Medicine1993;14:249-56.

Holick MF. Vitamin D: a D-lightful health perspective. Nutrition Rev 2008;66:182-94.

Shi L, Nechuta S, Gao YT, Zheng Y, Dorjgochoo T, Wu J et al. Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients. PLOS ONE 2014; 9(1): e86467.

Kim JR, Kim BH, Kim SM, Oh MY, Kim WJ, Jeon YK et al. Low Serum 25 Hydroxyvitamin D Is Associated with Poor Clinicopathologic Characteristics in Female Patients with Papillary Thyroid Cancer. Thyroid 2014;24:1618-24.

Marquardt P, Krause R, Schaller M, Bach D, Von-Gersdorff G. Vitamin D status and cancer prevalence of hemodialysis patients in Germany. Anticancer Res 2015;35:1181-7.

Mohr SB. A Brief History of Vitamin D and Cancer Prevention. Ann Epidemiol 2009;19:79-83.

Ylikomi T, Laaksi I, Lou, YR, Martikainen P, Miettinen S, Pennanen P et al. Antiproliferative action of vitamin D. Vitam. Horm 2002; 64:357-406.

Malumbres M. Physiological relevance of cell cycle kinases. Physiol. Rev 2011;91: 973-1007.

Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454:436-44.

Ohlsson B, Albrechtsson E, Axelson J. Vitamins A and D but not E and K decreased the cell number in human pancreatic cancer cell lines, Scand. J. Gastroenterol 2004;39:882–5.

Persons KS , Eddy VJ, Chadid S, Deoliveira R, Saha AK, Ray R. Anti- growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1- beta-4-ribofuranoside in pancreatic cancer cells, Anticancer Res 2010;30:1875–80.

Yao S, Sucheston LE, Millen AE, Johnson CS, Trump DL, Nesline MK, et al. Pretreatment Serum Concentrations of 25-Hydroxyvitamin D and Breast Cancer Prognostic Characteristics: A Case-Control and a Case- Series Study. PLoS One. 2011:28;6(2):e17251. doi: 10.1371/journal. pone.0017251.

Wieczorek K, Braczkowski RS, Skrzypek M, Stryjewski PJ, Kuczaj A, Al- Srory G. The comparison between vitamin d concentration in upper silesia patients with prostate cancer and with benign prostatic hyperplasia. J Biol Regul Homeost Agents 2015;29:207-11.

Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC et al. A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas. N Engl J Med 2015; 373:1519-30.

Galunska B, Gerova D, Kosev P, Anakievski D, Hinev A. Serum 25-hydroxy vitamin D levels in Bulgarian patients with prostate cancer: a pilot study. Clin Lab 2015;61:329-35.

Debatin KM. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol. Immunother 2004;53:153-9.

Chiang KC, Yeh CN, Chen MF, Chen TC. Hepatocellular carcinoma and vitamin D: a review. J. Gastroenterol. Hepatol 2011; 26:1597- 603.

Roskies M, Dolev Y, Caglar D, Hier MP, Mlynarek A, Majdan A et al. Vitamin D Deficiency as a Potentially Modifiable Risk Factor for Thyroid Cancer. Journal of Otolaryngology-Head & Neck Surgery 2012;41:160-3.

Morris LG, Myssiorek D. Improved detection does not fully explain the rising incidence of well-differentiated thyroid cancer: a population-based analysis. Am J Surg 2010;200:454-61.

Milczarek M, Rosinska S, Psurski M, Maciejewska M, Kutner A, Wietrzyk J. Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin. Anticancer Res 2013; 33:433-44.

Milczarek M, Psurski M, Kutner A, Wietrzyk J. Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model. BMC Cancer 2013;13:294.

Ajibade AA, Kirk JS, Karasik E, Gillard B, Moser MT, Johnson CS et al. Early Growth Inhibition Is Followed by Increased Metastatic Disease with Vitamin D (Calcitriol) Treatment in the TRAMP Model of Prostate Cancer. Plosone 2014;9(2): e89555.