Çocuklarda akut semptomatik nöbetin oldukça nadir bir nedeni: Kayısı çekirdeği yutulması

Çocuklukta nöbetlerin en sık nedenlerinden biri akut semptomatik nöbettir. Nöbetin tekrarlama riskini tahmin etmek için sorunun kökündeki tetikleyici unsuru belirlemek çok önemlidir. Siyanür, mitokondriyal sitokrom oksidazın inaktivasyonu yoluyla hücre oksijen kullanımını ve hücresel solunumu inhibe eder. Siyanür, insan vücudu için şimdiye kadar keşfedilen en öldürücü toksinlerden biridir. Erken tedavi, ölüm dahil zararlı sonuçların önlenmesini sağlar. Bu vaka sunumu, birkaç kayısı çekirdeği yedikten sonra akut semptomatik nöbet ile başvuran ve siyanür zehirlenmesinden şüphelenildikten sonra panzehirle hızla iyileşen 2 yaşındaki bir kız çocuğunu sunmaktadır. Hasta siyanür zehirlenmesinin uzun süreli etkisi görülmeden taburcu edilmiştir.

Anahtar Kelimeler:

Siyanür, Çocuk, akut semptomatik nöbet

An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion

One of the most frequent causes of seizures in children is an acute symptomatic seizure. To forecast risk of recurrence of seizure, it's crucial to identify the trigger element at the root of the problem. Cyanide inhibits cell oxygen utilization and cellular respiration through inactivation of mitochondrial cytochrome oxidase. Cyanide is one of the most lethal toxins ever discovered for the human body. Early treatment enables the avoidance of harmful outcomes, including death. This case report represents case of a 2-year-old girl presented with an acute symptomatic seizure after eating a few apricot kernels and her quick recovery with antidote after cyanide poisoning was suspected. The patient was discharged without experiencing any long-term effects of cyanide poisoning.

Keywords:

Cyanide, children, acute symptomatic seizure,

Tam Metin

___

Nardone R, Brigo F, Trinka E. Acute Symptomatic Seizures Caused by Electrolyte Disturbances. J Clin Neurol. 2016 ;12(1):21-33. doi: 10.3988/jcn.2016.12.1.21.
Peddy SB, Rigby MR, Shaffner DH. Acute cyanide poisoning. Pediatr Crit Care Med. 2006;7(1):79-82. doi: 10.1097/01.pcc.0000192508.92993.d1.
Geller RJ, Barthold C, Saiers JA, Hall AH. Pediatric cyanide poisoning: causes, manifestations, management, and unmet needs. Pediatrics. 2006; 118(5):2146-58. doi: 10.1542/peds.2006-1251.
Geslain G, Tilea B, Heraut F, Rubinsztajn R. Smoke inhalation injury in a 2-year-old domestic fire victim. Arch Pediatr. 2020 May;27(4):223-226. doi: 10.1016/j.arcped.2020.01.008.
Akıl M, Kaya A, Ustyol L, Aktar F, Akbayram S. Acute cyanide intoxication due to apricot seed ingestion. J Emerg Med. 2013; 44(2):e285-6. doi: 10.1016/j.jemermed.2012.05.041.
Unal O, Ozen O, Caksen H. Acute Cyanide Intoxication Related to Apricot Seed: The Findings of Cranial Magnetic Resonance Imaging. J.Neurol.Sci. 2016; 33(1); 171-176.
Yulvianti M, Zidorn C. Chemical Diversity of Plant Cyanogenic Glycosides: An Overview of Reported Natural Products. Molecules. 2021;26(3):719. doi: 10.3390/molecules26030719.
Zhang D, Ye J, Song Y, Wei Y, Jiang S, Chen Y, Shao X. Isomerization and Stabilization of Amygdalin from Peach Kernels. Molecules. 2023;28(11):4550. doi: 10.3390/molecules28114550.
Cigolini D, Ricci G, Zannoni M, et al. Hydroxocobalamin treatment of acute cyanide poisoning from apricot kernels. BMJ Case Rep. 2011;bcr0320113932. doi: 10.1136/bcr.03.2011.3932.
Leavesley HB, Li L, Prabhakaran K, Borowitz JL, Isom GE. Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol Sci. 2008;101(1):101-11. doi: 10.1093/toxsci/kfm254.
Chen F, Jiang L, Yang B. Visual loss caused by acute cyanide poisoning: a case report. Clin Toxicol (Phila). 2011;49(2):121-3. doi: 10.3109/15563650.2011.556643.
Cmorej P, Bruthans P, Halamka J, Voriskova I, Peran D. Life-Threatening Cyanide Intoxication after Ingestion of Amygdalin in Prehospital Care. Prehosp Emerg Care. 2022;26(3):455-458. doi: 10.1080/10903127.2021.1924903.
Schwarz ES. Inhalants. Crit Care Clin. 2021;37(3):687-702. doi: 10.1016/j.ccc.2021.03.014.
Graham J, Traylor J. Cyanide Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. 2023 Feb 13.
Bıcılıoğlu Y, Yıldırım İ, Özkaya PY, Bal A. Pediatric cyanide poisoning after ingestion of apricotseeds. JPediatr Emerg Intensive Care Med. 2020;7(2):85-8.
Rice NC, Rauscher NA, Langston JL, Myers TM. Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery. Food Chem Toxicol 2018;114:145–54. https://doi.org/10.1016/J.FCT.2018.02.033.
Moffett BS, Price JF. Evaluation of sodium nitroprusside toxicity in pediatric cardiac surgical patients. Ann Pharmacother 2008;42:1600–4. https://doi.org/10.1345/APH.1L192.
Thomas C, Svehla L, Moffett BS. Sodium-nitroprusside-induced cyanide toxicity in pediatric patients. Expert Opin Drug Saf 2009;8:599–602. https://doi.org/10.1517/14740330903081717.

___

Bibtex	@olgu sunumu { abantmedj1324250, journal = {Abant Tıp Dergisi}, issn = {1305-4392}, eissn = {2147-1800}, address = {Abant Tıp Dergisi Editörlüğü Bolu Abant İzzet Baysal Üniversitesi Tıp Fakültesi, 14280 / BOLU}, publisher = {Bolu Abant İzzet Baysal Üniversitesi}, year = {2023}, volume = {12}, number = {2}, pages = {146 - 150}, doi = {10.47493/abantmedj.1324250}, title = {An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion}, key = {cite}, author = {Dokurel, İpek and Çeneli, Cansen} }
APA	Dokurel, İ. & Çeneli, C. (2023). An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion . Abant Tıp Dergisi , 12 (2) , 146-150 . DOI: 10.47493/abantmedj.1324250
MLA	Dokurel, İ. , Çeneli, C. "An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion" . Abant Tıp Dergisi 12 (2023 ): 146-150 <
Chicago	Dokurel, İ. , Çeneli, C. "An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion". Abant Tıp Dergisi 12 (2023 ): 146-150
RIS	TY - JOUR T1 - Çocuklarda akut semptomatik nöbetin oldukça nadir bir nedeni: Kayısı çekirdeği yutulması AU - İpekDokurel, CansenÇeneli Y1 - 2023 PY - 2023 N1 - doi: 10.47493/abantmedj.1324250 DO - 10.47493/abantmedj.1324250 T2 - Abant Tıp Dergisi JF - Journal JO - JOR SP - 146 EP - 150 VL - 12 IS - 2 SN - 1305-4392-2147-1800 M3 - doi: 10.47493/abantmedj.1324250 UR - Y2 - 2023 ER -
EndNote	%0 Abant Tıp Dergisi An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion %A İpek Dokurel , Cansen Çeneli %T An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion %D 2023 %J Abant Tıp Dergisi %P 1305-4392-2147-1800 %V 12 %N 2 %R doi: 10.47493/abantmedj.1324250 %U 10.47493/abantmedj.1324250
ISNAD	Dokurel, İpek , Çeneli, Cansen . "An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion". Abant Tıp Dergisi 12 / 2 (Ağustos 2023): 146-150 .
AMA	Dokurel İ. , Çeneli C. An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Med J. 2023; 12(2): 146-150.
Vancouver	Dokurel İ. , Çeneli C. An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Tıp Dergisi. 2023; 12(2): 146-150.
IEEE	İ. Dokurel ve C. Çeneli , "An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion", , c. 12, sayı. 2, ss. 146-150, Ağu. 2023, doi:10.47493/abantmedj.1324250