Özgül ÖZGAN ÇELİKEL, Emine UNAL, Özlem DOĞAN, Nurkan AKSOY

Akne Vulgarisli Gebelerde A Vitamini Düzeyi ve Vücut Kitle İndeksinin İncelenmesi

Giriş: Gebelerde değişen şiddetlerde akne vulgaris kliniği görülebilmektedir. Bu çalışmamanın amacı; A vitamini seviyesi ve vücut kitle indeksi (VKI)’nin gebelerde akne oluşumu üzerine etkisi olup olmadığını araştırmaktır. Gereç ve Yöntem: Çalışmaya gebeliğin ikinci trimesterinde bulunan aknesi olan 40 kadın ve aknesi olmayan 38 kadın dahil edilmiştir. Akne tanısı “Global Akne Derecelendirme Sistemi (GADS)” ‘ne göre yapılmıştır. Serum vitamin A düzeyine Elabscience (USA) marka ELISA kiti ile bakılmıştır. İstatistiksel analizlerde anlamlılık p<0,05 olarak kabul edilmiştir. Bulgular: Grupların yaş ortalaması, gravida, gebelik sayısı, açlık kan şekeri, hemoglobin düzeyleri benzer olarak bulunmuştur. Akneli grupta tüm katılımcılar hafif ve orta şiddette akne tanısı almıştır. Aknesi olan gebe grubunda A vitamini düzeyi (94,41±16,47 ) kontrol grubuna (101,37±12,75) göre daha düşük olarak tespit edilmiştir (p=0,002). VKI akne vulgarisli gebe grubunda daha yüksek bulunmuştur (p=0,000). VKI ile vitamin A düzeyi arasında negatif yönde düşük düzeyde doğrusal ilişki saptanmıştır (r= -0,273; p=0,017). Sonuç: Gebelerde akne oluşumunda vitamin A eksikliğinin ve VKI yüksekliğinin rolü olabileceği düşünülmektedir. VKI yüksekliğinin; doğrudan ya da A vitamini düşüklüğüne sebep olarak akne vulgaris gelişimine sebep olabileceği kanaatine

Anahtar Kelimeler:

gebelik, , akne vulgaris, vitamin A

PDF

___

1. Mays RM, Gordon RA, Wilson JM, et al. New antibiotic therapies for acne and rosacea. Dermatol Ther. 2012;25(1):23–37.
2. Bataille V, Snieder H, MacGregor AJ,et al. The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. J Invest Dermatol 2002;119:1317–1322
3. Fried RG, Wechsler A. Psychological problems in the acne patient. Dermatol Ther. 2006;19(4):237–40.
4. Wong JW, Heller MM, Murase JE. Caution advised in interpretation of US FDA risk classification for dermatological medications during pregnancy. Dermatol Online J. 2012;18(10):15.
5. Dekkers OM , Thio BH , Romijn JA , Smit JWLeids Universitair Medisch Centrum, afd. Endocrinologie, Postbus 9600, 2300 RC Leiden. o.m.dekkers@lumc.Nederlands Tijdschrift Voor Geneeskunde [2006, 150(23):1281-1285]
6. Eken A. Kozmesötik Etken Maddeler. 1. Baskı, Ankara; Türkiye Klinikleri; 2006
7. Kaňová N , Bičíková. Hyperandrogenic states in pregnancy. MInstitute of Endocrinology, Prague, Czech Republic. nkanova@endo.czPhysiological Research / Academia Scientiarum Bohemoslovaca (2011, 60(2):243-252)
8. Guy F Webster, professor. Acne vulgaris. BMJ. 2002 Aug 31; 325(7362): 475–479.
9. Wu GR, Jing S, Momma K and Nakanishi T: The effect of vitamin A on contraction of the ductus arteriosus in fetal rat. Pediatr Res. 49:747–754. 2001.
10. Chagas CB, Saunders C, Pereira S, Silva J, Saboya C and Ramalho A: Vitamin a deficiency in pregnancy: Perspectives after bariatric surgery. Obes Surg. 23:249–254. 2013. 11. Ismail NH, Manaf ZA, Azizan NZ. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study. BMC Dermatol 2012;12:13
12.Katzman M, Logan AC. Acne vulgaris: nutritional factors may be influencing psychological sequelae. Med Hypotheses 2007;69:1080–1084
13. Rollman O, Vahlquist A. Oral isotretinoin (13-cis-retinoic acid) therapy in severe acne: drug and vitamin A concentrations in serum and skin. J Invest Dermatol 1986;86:384–389
14. Doshi A, Zaheer A, Stiller MJ: A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 1997;36:416-8.
15. B. Dréno, E. Blouin, D. Moyse, et al. Acne in pregnant women: a French survey Acta Derm Venereol, 94 (2014), pp. 82-83
16. C.C. Yang, Y.T. Huang, C.H. Yu, et al. Inflammatory facial acne during uncomplicated pregnancy and post-partum in adult women: a preliminary hospital-based prospective observational study of 35 cases from Taiwan. J Eur Acad Dermatol Venereol, 30 (2016), pp. 1787-1789
17. Di Landro A, Cazzaniga S, Parazzini F, Ingordo V, Cusano F, Atzori L, Cutrì FT, Musumeci ML, Zinetti C, Pezzarossa E, et al.. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J Am Acad Dermatol. 2012;67(6):1129.
18. Halvorsen JA, Vleugels RA, Bjertness E, Lien L. A population-based study of acne and body mass index in adolescents. Arch Dermatol. 2012. January;148(1):131–2.
19. Karolina Sas, Adam Reich. High Body Mass Index is a Risk Factor for Acne Severity in Adolescents: A Preliminary Report. Acta Dermatovenerol Croat. 2019 Jun;27(2):81-85.
20. L E Anaba 1, O A Ogunbiyi, O A George. Adolescent Facial Acne Vulgaris and Body Mass Index: Any Relationship? West Afr J Med. May-Aug 2019;36(2):129-132.
21. Gabriel S, Mihaela I, Angela B, Mariana A, Doru D. Prevalence of IgA antitissue transglutaminase antibodies in children with type 1 diabetes mellitus. J Clin Lab Anal. 2011;25(3):156–61.
22. Omer Kutlu, MD, MRCP, Ayse Serap Karadag, MD, Emine Unal, MD, Kıymet Handan Kelekci, MD, Aysegul Yalcınkaya. Acne in pregnancy: A prospective multicenter, crosssectional study of 295 patients in Turkey. International Journal of Dermatology 2020
23. Chen H, Qian N, Yan L, Jiang H. Role of serum vitamin A and E in pregnancy. Exp Ther Med. 2018 Dec;16(6):5185-5189.
24. El-Akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition? Clin Exp Dermatol 2006;31:430–434
25. Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, Kalkan G. Jul 5.Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris Cutan Ocul Toxicol. 2014 Jun;33(2):99-102
26. Alicja Kucharska, Agnieszka Szmurło, Beata Sińska. Significance of diet in treated and untreated acne vulgaris. Postepy Dermatol Alergol 2016 Apr;33(2);81-6.
27. Cengiz F. P. Emiroğlu N. Bahalı A. G. Su Ö. Onsun N. Vitamin A and E Levels in Patients with Mild and Moderate Acne. Bezmialem Science 2017; 5: 61
28. Schreiber R, Taschler U, Preiss-LandL K, et al. Retinyl ester hydrolases and their roles in vitamin A homeostasis. Biochim Biophys Acta 2012;23:113-23.
29. Pang XY, Wang S, Jurczak MJ, et al. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Arch Biochem Biophys 2017;633:93-102.
30. Rumana Yasmeen R, Shanmugam M, Jeyakumar A, et al. The contribution of vitamin A to autocrine regulation of fat depots. Biochim Biophys Acta 2012;1821(1):190-7.
31. Vincenta H, Bourguignonb C, Weltmanc A, et al. Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism 2009;58(2):254-62.
32. Syauqy A, Hsu CY, Rau HH, et al. Association of dietary patterns with components of metabolic syndrome and inflammation among middle-aged and older adults with metabolic syndrome in Taiwan. Nutrients 2018;10(2):143.
33. Bressan J, Hermsdorff L, Zulet A, et al. Impacto hormonal e inflamatório de diferentes composições dietéticas: ênfase em padrões alimentares e fatores dietéticos específicos. Arq Bras Endocrinol Metab 2009;572-81.
34. Claudia Bento, Andréa C Matos, Adryana Cordeiro 1, Andréa Ramalho. Vitamin A deficiency is associated with body mass index and body adiposity in women with recommended intake of vitamin A. Nutr Hosp . 2018 Oct 5;35(5):1072-1078.