Spermatogenesis süreçlerinin düzenlenmesinde GDNF’nin ( gliyal hücre türevi nörotropik factor ) rolü

Spermatogenesis pek çok faktörün direk/dolaylı etkilediği ve hayat boyu devam eden karmaşık bir süreçtir. Spermatogonial kök hücre transplantasyonu ve spermatogenesisin in-vitro kültüründeki teknik gelişmeler bu faktörler kombinasyonunun anlaşılması yönünde özgün deneme kurgularının oluşturulmasına olanak tanımaktadır. Bu bağlamda spermatogenesiste önemli bir büyüme faktörü olarak GDNF (gliyal hücre türevi nörotropik faktör), spermatogonial kök hücrelerinin kendilerini yenileme ve farklılaşmasında belirleyici rol oynamaktadır. Şimdiye kadar yapılan çalışmalarda GDNF’in spermatogenesisin düzenlenmesindeki bu eşsiz rolü apaçık gösterilmekte ve spermatogonianın kendini yenileme ve farklılaşma yönündeki aktivitesinin GDNF karmaşık işaretsel ağı içinde gerçekleştiği belirtilmektedir. Sonuç olarak çiftlik hayvanlarında döl verimi moleküler düzeyde tanımlanabilmekte ve buna ilişkin problemlerin giderilmesi yönünde etkili yöntemlerin geliştirilmesi sağlanmaktadır.

The role of the GDNF (glial cell line-derived neurotropic factor) in regulating of the spermatogenesis processes

Spermatogenesis is a complex and continuing process in which many factor plays a role directly or indirectly. Transplantation of the spermatogonial stem cells and its culture as in-vitro offers an immense potential to set up original experiment designs concerning with understanding of these factor combinations in spermatogenesis mechanism. As an important factor in spermatogenesis, GDNF (Glial Cell Line-Derived Neurotropic Factor) plays a vital role in renewal and differentiation of the spermatogonial stem cells. So far, studies done have clearly showed that GDNF plays an important role in regulating of the spermatogenesis and determines renewal or differentiation of the spermatogonial stem cells, maintaining spermatogonia population. As a result, spermatogenesis has been defined in molecular level and effective methods to study the problems of the infertilities in domesticated animals iw being developed.

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