Prematüre retinopatisinde intravitreal anti-VEGF tedavisi

Prematüre retinopatisi (PR) retinal vasküler gelişim bozukluğuna bağlı olarak oluşan, çocukluk çağındaki en önemli körlük nedenleri arasında yer alan bir hastalıktır. İmmatür retinaya sekonder olarak gelişen hipoksi ve bunun sonucunda ortama salınan birtakım mediatörler hastalığın karakteristik ‘ilerleyici retinopati’ özelliğini oluşturur. Bu mediatörler arasında hastalığın patogenezinde en etkin olanı VEGF (vasküler endotelyal büyüme faktörü)’tir. Literatürde hastalığın tanısı ve tedavisi ile ilgili kriterler belirlenmiş olup, son yıllarda özellikle anti-VEGF tedavi ile başarılı sonuçlar ortaya konmuştur. Bu makalede, PR tanımı, tarama, takip kriterleri ve patogenezinden özet olarak bahsedilmiş olup, özellikle hastalık tedavisinde anti-VEGF ajanların kullanımı ile ilgili güncel bilgiler gözden geçirilmiştir.

Anahtar Kelimeler:

Vasküler Endotelyal Büyüme Faktörü, intravitreal enjeksiyonlar, prematüre retinopatisi, monoklonal antikorlar

Intravitreal anti-VEGF therapy in retinopathy of prematurity

Retinopathy of prematurity (ROP) is the retinal vascular developmental disorder of the premature infants and it is a leading cause of childhood blindness. Hypoxia secondary to the immature retina with subsequent release of some mediators establish the characteristic feature of ‘progressive retinopathy’. The most promoter one among these mediators is vascular endothelial growth factor (VEGF). The screening and treatment criteria were identified in past literature and successful treatment results were revealed especially with anti-VEGF therapy in recent years. In this article, definition, screening, follow-up criteria and pathogenesis of ROP are summarized and current knowledge of anti-VEGF agent use in the treatment of the disease is reviewed.

Keywords:

Vascular Endothelial Growth Factors, intravitreal injections, retinopathy of prematurity, monoclonal antibodies,

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