Levent MDYAT, Aşan ÖNDER, Gabil MURSALOV, Yasemin ÖZDEMİR, Sevgi MİR

Kızamıkçık ve hepatit B aşısı sonrası görülen bir Guillan-Barre sendromu olgusu

Guillain-Barre Sendromu (GBS), çoğunlukla hızlı ilerleyen, simetrik güçsüzlük ve arefleksi ile karakterize, akut enflamatuar birpolinöropatidir. Enfeksiyöz ajanların, aşıların, cerrahi girişimlerin ve doğum sürecinin bu hastalığın oluşumunu tetikleyebildiği iddia edilmektedir. Bu çalışmada, hepatit B ve kızamıkçık aşıları uygulamasından bir hafta sonra yürümede bozukluk şikayetiyle başvuran ve tedavi sonrası minimal sekelle düzelen on bir yaşında bir olgu sunulmuş ve literatür bilgileri incelenerek, aşı-GBS ilişkisi araştırılmıştır.

Anahtar Kelimeler:

Guillain-Barre sendromu, Çocuk, Erkek, Hepatit B aşıları, İlaç yan etkisi raporlama sistemleri, Kızamıkçık aşısı, Yan etkiler

Guillan-Barre syndrome due to rubella and hepatitis B vaccination: A case report

Guillain-Barre Syndrome (GBS) is an acute inflammatory polyneuropathy which is most commonly characterized by rapidly progressive, essentially symmetric weakness and areflexia. Infectious agents, immunizations, surgery or parturition may trigger formation of the disease. In this study, an eleven years old child is reported, who had symptoms of walking disabilities one week after the hepatitis B and rubella vaccination and who almost fully recovered except for small weakness in the ankle dorsiflexors. Also, relation of GBS and vaccines is investigated with the aid of literature.

Keywords:

Guillain-Barre Syndrome, Child, Male, Hepatitis B Vaccines, Adverse Drug Reaction Reporting Systems, Rubella Vaccine, Adverse effects,

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1.Schessl J, Luther B, Kirschner J, Mauff G, ve ark. Infections and vaccinations preceding childhood Guillain-Barre syndrome: a prospective study. 2006;165:605-12
2.Rantala H, Cherry JD, Shields WD, Uhari M. Epidemiology of Guillain-Barre syndrome in children: relationship of oral polio vaccine administration to occurrence. J Pediatr 1994,-124:220-3
3.Asbury AK. New concepts of Guillain-Barre syndrome. J Child Neurol 2000; 15:183-91 4.Midyat L, Egemen A. Çocukluk çağı aşıları ve thiomersal. Ege Pediatri Bülteni 2007;14:53-62
5.Souayah N, Nasar A, Suri MFK, Qureshi AL Guillain—Barre syndrome after vaccination in United States A report from the CDC/FDA Vaccine Adverse Event Reporting System. Vaccine 2007;25:5253-5.
6.Lasky T, Terracciano GJ, Magder L, Koski CL, ve ark. The Guillain-Barre syndrome and the 1992-1993 and 1993-1994 influenza vaccines. N EnglJMed 1998;339:1797-802
7.Ryan MM. Guillain-Barre syndrome in childhood.J.Paediatr.Child Health 2005;41:237-41
8.Asbury AK, Cornblath DR. Assessment of current diagnostic criteria for Guillain—Barre syndrome. Ann. Neurol 1990;27(Suppl.):21-4
9.Hughes RA, Charlton J, Latinovic R, Gulliford MC. No association between immunization and Guillain-Barre syndrome in the United Kingdom, 1992 to 2000. 2006,-166:1301-4
10.Schonberger LB, Bregman DJ, Sullivan-Bolynai JZ, ve ark. Guillain-Barre syndrome following vaccination in the National Influenza Immunization Program, United States 1976-1977. Am J Epidemiol. 1979;110:105-23
11.Anlar O, Tombul T, Arslan S, Akdeniz H, ve ark. Report of five children with Guillain-Barre syndrome following a nationwide oral polio vaccine campaign in Turkey. 2003; 51:544-5
12.Patja A, Paunio M, Kinnunen E, Junttilla O, ve ark. Risk of Guillain-Barre syndrome after measles-mump s-rub ell a vaccination. 2001;138:250-4
13.R.A. Hughes and D.R.Cornblath, Guillain—Barre syndrome,Lancet 2005;366:1653-66
14.Sladky JT. Guillain-Barre syndrome in children. J Child Neurol. 2004; 19:191-200
15.Brads haw DY, Jones HR Jr. Guillain-Barre syndrome in children:Clinical course, electrodiagnosis, and prognosis. Muscle Nevre 1992,-15:500-6
16.Korinthenberg R, Monting JS. Natural history and treatment effects in Guillain-Barr 'e syndrome: A multicentre study. Arch. Dis. Child 1996; 74: 281-7
17.Demir SE, Aydın G. Guillain Barre Sendromu rehabilitasyonu. Romatizma 2001:2:107-13
18.Cruse RP. Treatment of Guillain-Barre syndrome in children.
19.Aşı Çalışma Grubu. Aşı yan etkileri, http ://www.asicalismagrubu. org/asi_y an _etkileri. asp