Sema DEMİRBAŞOĞLU, Berna HALİLOĞLU, Barış MÜLAYİM, Evrim AKSOY, Ateş KARATEKE

Erken doğum tehdidinde risk faktörlerinin belirlenmesi

Amaç: Neonatal mortalitenin %83 ü preterm doğumlardan kaynaklanan nedenlere bağlıdır. Çalışmamızda erken doğuma yol açan risk faktörlerinin belirlenmesi amaçlanmıştır. Materyal Metod: Mayıs 2001 Aralık 2001 tarihleri arasında açıklanamayan nedenli erken doğum tehdidi tanısıyla interne edilen 112 olgu ve kontrol grubu olarak 55 gebe çalışmamıza dahil edilmiştir, istatistiksel analiz için SSPS VIO paket programı kul-lanılmış ve anlamlılık p

Anahtar Kelimeler:

Doğum, prematür, Risk faktörleri, Gebelik komplikasyonları, Yaş faktörü, Vücut kitle indeksi, Hemoglobinler

Determination of risk factors at threatened preterm labor

Objective: %83 of neonatal mortalities are due to preterm births. In our research we tried to determine the risk factors which causes preterm birth (labor). Materials and Methods: Between May 2001-December 2001, 112 cases which were diagnosed as threatened labor and whose etiology unknown includ-ed as study group and 55 pregnant women were included as the control group. For statistical analyses SSPS V10 program were used and the values of p

Keywords:

Labor, Premature, Risk Factors, Pregnancy Complications, Age Factors, Body Mass Index, Hemoglobins,

___

1. American College of Obstetricians and Gynecologists: Preterm Lahor. Technical Bulletin. No. 206, June 1995 2. Creasy RK, Resnik R: Maternal-Fetal Medicine WB Saunders Company, 1999; 498
3. Collaborative Group on Antenatal Steroid Theraphy: Effect of antenatal dexamethazone administration on the prevention of respiratory distress syndrome. Am J Obstet Gynecol 141: 276, 1981 4. Joseph KS, Kramer MS, Marcoux S, Ohlsson A, Wen SW, Allen A, Plait R: Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994. N EnglJ Med 339: 1434, 1998 5. F.Gary Cunningham , Norman F.Gant, Kenneth J. Leveno, Larry C.Gilstrap III, John C. Hauth, Katharine D. Wenstrom: Preterm birth. Me Graw-Hill Companies, 2001; 689-727 6. Copper RL, Goldenberg RL, Creasy RK: A multicenter study of preterm birth weight and gestational age specific mortality. Am J Obstet Gynecol, 1993; 168: 78
7. Meis PJ, Ernest JM, Moore ML: Regional program for prevention of premature birth in northwestern North Carolina. Am J Obstet Gynecol, 1987; 157: 550
8. Meis PJ, Goldenberg RL, Mercer BM, lams JD, Moawad AH, Miodovnik M, Menard MK, Caritis SN, Thurnau GR, Bottoms SF, Das A, Roberts JM, McNellis D:The preterm prediction study: Risk factors for indicated preterm births. Maternal Fetal Medicine Units Network of the National Institute of Child Health and Human Development. AmJ Obstet Gynecol 178:562, 1998 9. Meis PJ, Michielutte R, Peters TJ, Wells HB, Sands RE, Coles EC, Johns KA.Factors associated with preterm birth in Cardiff, Wales, I. Univariable and multivariable analysis. Am J Obstet Gynecol 173:590, 1995b 10. Kramer MS: Birthweight and infant mortality: Perceptions and pitfalls. Pediatr Perinat Epidemiol, 1990; 4: 381-389
11. Hickey CA, Cliver SP, McNeal SF, Goldenberg RL: Low pregravid body mass index as a risk factor for preterm birth: Variation by ethnic group. Obstet Gynecol, 1997; 89: 206-212
12. Edwards LE, Alton JR, Barrada MI, Hakanson EY: Pregnancy in the underweight woman: Course, outcome, and growth patterns of the infant. AmJ Obstet Gynecol, 1979; 135: 297-302
13. Brown JE, Jacobson HN, Askue LH, Peick MG: Influence of prepregnancy weight gain on the size of infants born to underweight women. Obstet Gynecol, 1981; 57: 13-17
14. Kramer MS: Determinants of low birth weight: Methodological assesment and meta-analysis. Bull World Health Organ, 1987; 65: 663-737
15. Kramer MS, Coates AS, Michoud M-C, Dagenais S, Hamilton EF, Papageorgiou A: Maternal anthropometry and idiopatine preterm labor. Obstet Gynecol, 1995; 86: 744-748J 16. Abrams B, Newman V, Key T, Parker J: Maternal weight gain and preterm delivery. Obstet Gynecol, 1989; 74: 577-583
17. Hickey CA, Cliver SP, McNeal SF, Hoffman HJ, Goldenberg RL: Prenatal weight gain patterns and spontaneous preterm birth among nonobese black and white women. Obstet Gynecol, 1995; 85: 909-914
18. Hediger ML, Scholl TO, Belsky DH, Ances I, Salmon RW: Patterns of weight gain in adolescent pregnancy: Effects on birth weight and preterm delivery. Obstet Gynecol, 1989; 74: 6-12
19. Subcommittee on Nutritional Status and Weight Gain During Pregnancy, Institute of Medicine. Nutrition during pregnancy
Washington, DC: National Academy Press, 1990
20. James WPT: Introduction: The challenge of adult chronic energy deficiency. EurJ Clin Nutr, 1994; 48: Sl-9
21. Wildschut HIJ, Nas T, GöldingJ. Are sociodemographic factors predictive of preterm birth? A reappraisal of the 1958 British Perinatal Mortality Survey. BrJ Obstet Gynecol, 1997; 104: 57-63
22. Gilstrap LC, Ramin SM: Urinary tract infections during preg¬ nancy. Obstet Gynecol Clin North Am, 2001; 28: 581-591
23. Dayan J, Creveuil C, Herlicoviez M et al: Role of anxiety and depression in the onset of spontaneous preterm labor. Am J Epidemiol, 2002; 155: 293-301
24. Covington DL, Hage M, Hall T, Mathis M: Preterm delivery and severity of violence during pregnancy. J Reprod Med, 2001; 46: 1031-1039
25. Monaghan SC, Little RE, Hulchiy O, Strassner H, Gladen BC: Risk factors for spontaneous preterm birth in two urban areas of Ukraine. Pediatr Perinat Epidemiol, 2001; 15: 123-130
26. Bondevik GT, Lie RT, Ulstein M, Kvale G: Maternal hematological status and risk of low birth weight and preterm delivery in Nepal. Ada Obstet Gynecol Scand, 2001; 80(5): 402-408
27. Xiong X, Buekens P, Alexander S, Demianczuk N, Wollast E: Anemia during pregnancy and birth outcome: a meta-analysis. Am JPerinatol, 2000; 17: 137-146
28. Kyrklund-Blomberg NB, Cnattingius S: Preterm birth and maternal smoking: Risk related to gestational age and onset of delivery. Am] Obstet Gynecol, 1998; 179: 1051-1055
29. Berkowitz GS, Papiernik E: Epidemiology of preterm birth
Epidemiol Rev, 1993; 15: 414-443
30. Meis PJ, Micheluette R, Peters TJ et al: Factors associated with preterm birth in Cardiff, Wales. I. Unvariable and multivariable analysis .11. Indicated and spontaneous preterm birth. Am] Obstet Gynecol, 1995; 173: 590-602
31. Shiono PH, Klebanoff MA, Rhoads GG: Smoking and drinking during pregnancy: their effects on preterm birth. JAMA, 1986; 255: 82-84
CİLT: 33 YIL: 2002 SAYI: 3 32. Harlow BL, Frigoletto FD, Cramer DW et al: Determinants of preterm delivery in low risk pregnancies. J Clin Epidemiol, 1996; 49: 441-448
33. ChasnofflJ, Griffith DR, MacGregor SN: Temporal patterns of cocaine use in pregnancy. JAMA, 1989; 261: 1714
34. Cherukuri R, Minkoff H, Hansen RL: A cohort study of alkoloidal cocaine (crack) in pregnancy. Obstet Gynecol, 1988; 72: 147
35. Hillier SL, Nugent RP, Eshenbach DA: Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. N EnglJ Med, 1995; 333: 1737-42 36. Hoist E, Goffeng AR, Andersch B: Bacterial vaginosis and vaginal microorganisms in idiopathic premature labor and association with pregnancy outcome. J Clin Microbiol, 1994; 23: 176-186
37. Hay PE, Morgan DJ, Ison CA: A logitudinal study of bacterial vaginosis during pregnancy. British] Obstet Gynecol, 1994; 101: 1048-1053
38. Ancel PY, Saurel-Cubizolles Mj, Papiernik ER, Breart G: Very and moderate preterm births: are the risk factors different? British J Obstet Gynecol, 1999; 106: 1162-1170
39. Wright SP, Mitchell EA, Thompson ]M: Risk factors for preterm birth: a New Zealand study. N Z Med], 1998; 111(1058): 14-16
40. Tallo CO,Vohr V, Oh W: Maternal and neonatal morbidity associated with in vitro fertilization. ] Pediatr, 1995; 127: 794
41. Weis G, Goldsmith LT, Sachdev R: Elevated first trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery
Obstet Gynecol, 1993; 82: 821