Namık Kemal DURU, SEYİT TEMEL CEYHAN, İbrahim ALANBAY, Murat MUHCU, Uğur KESKİN, İskender BAŞER

Anti Müllerian Hormon düzeylerinin invitro fertilizasyonda kullanımı

Anti Müllerian Hormon (AMH) glikoprotein yapıda bir molekül olup temel olarak erkek seks diferensiasyonunda regulatuar rol oynamaktadır. Erkekte fetal testisin sertoli hücreleri tarafından salgılanmakta iken, dişilerde gelişmekte olan follikülün granüloza hücreleri tarafından s algılanmaktadır. Erkekte Müllerian kanal regresyonunda rol almakta olup, kadınlarda follikül seçiminin inhibisyonunda rol oynamaktadır. Antimüllerian hormon, erkekte, prenatal ve yeni doğan döneminde yüksek konsantrasyonlarda salınmakta olup, puberte döneminde düzeyi daha düşük seyretmektedir. Kadınlarda ise, puberte döneminde artış göstermeye başlayıp, reprodüktif dönemde en üst düzeye çıkmaktadır. Menopoz döneminde ise azalmaktadır. Follikülogeneziste, primordial follikül evresinden preantral follikül evresine geçiş olan inisiyel seçim aşamasında AMH inhibitor rol oynamaktadır. AMH seviyeleri IVF te; ovarian yanıt belirteci, ovarian rezerv belirteci, Lutealfaz belirteci, IVF outcome belirteci, PCOS tanı / tedaviye yanıt, POF- Kanser tedavisi sonrası ovarian hasar, Non-obstruktifAzospermi ve operatif ovarian hasarın değerlendirilmesinde kullanılabilmektedir.

Anahtar Kelimeler:

Anti-Mullerian Hormon, İnvitro fertilizasyon, Polikistik yumurtalık sendromu, Azoospermi

In vitro fertilization and Anti-Mullerian hormone

Anti-Mullerian hormone (AMH), is a glycoprotein structured molecule. AMH plays an important role in male sex differantiation and female folliculogenesis. It has an inhibitor role infolliculer selection period. It's serum consantrations increase in puberty, decrease in menapose andrnaximun in reproductive period in female. This review describes several studies showing that AMH serum level is avaiable to evaluate ovarian response, ovarian reserve, luteal phase and IVF outcome in IVF practise, and the diagnosis and management of polycistic over disease (PCOD) and primer ovarian failure (POF) due to cancer terapy, and non- obstructive asospermi and operative ovarian injury.

Keywords:

Anti-Mullerian Hormone, Fertilization in Vitro, Polycystic Ovary Syndrome, Azoospermia,

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