Murat TÜKEN, Emrah YÜRÜK, Ege Can ŞEREFOĞLU

Ürolojide botulinum nörotoksin kullanımı

Botulinum nörotoksin BoNT çeşitli ürolojik ve ürolojik olmayan hastalıkların tedavisinde, her geçen gün artan bir sıklıkla kullanılmaktadır. Üroloji alanındaki bilgilerin büyük bölümü onabotulinumtoksin A’nın Botox® mesane / detrüsör aşırı aktivitesi DAA , detrüsör-sfinkter dissinerjisi A Botox® into the urethra, prostate, bladder and DSD , benign prostat hiperplazisi BPH , intersipelvic floor for the treatment of voiding and sexual siyel sistit İS / ağrılı mesane sendromu AMS , kronik pelvik ağrı sendromu KPAS ve prematür ejakulasyon PE gibi işeme ve cinsel fonksiyon bozuklukları tedavisinde; üretra, prostat, mesane ve pelvik tabana enjekte edilmesiyle elde edilmiştir.Yapılan çalışmalar BoNT’un dikkatli bir şekilde uygulandığında yüksek etkinlik sağladığını ve düşük yan etki profili ile hastalar tarafından iyi tolere edilebildiğini göstermektedir. Ancak verse event profile. However, multi-center studies BoNT’un uzun dönem etkinlik ve yan etki özellikwith longer follow-up period are required for elulerinin daha iyi değerlendirilebilmesi için çok merkezli ve uzun takip süreli çalışmalara ihtiyaç vardır

Anahtar Kelimeler:

Benign prostat hiperplazisi, Botulinum nörotoksin, Detrüsör aşırı aktivitesi, Detrüsör-sfinkter dissinerjisi, İntersisiyel sistit, İşeme fonksiyon bozuklukları, Kronik pelvik ağrı

Botulinum neurotoxin use in urology

Botulinum neurotoxin BoNT is increasingly being used for treating various urological and non-urological disorders. Most of our knowledge regarding its use for urological conditions is gathered from the injection of onabotulinumtoxin A Botox® into the urethra, prostate, bladder and pelvic floor for the treatment of voiding and sexual dysfunctions such as bladder / detrusor overactivity, detrusor – sphincter dyssynergia, benign prostatic hyperplasia, interstitial cystitis / painful bladder syndrome, chronic pelvic pain and premature ejaculation. Numerous clinical trials demonstrated that carefully performed BoNT injections are well tolerated because of their high efficacy and low adverse event profile. However, multi-center studies with longer follow-up period are required for elucidating the long-term efficacy and side effects of BoNT therapy

Keywords:

Benign prostatic hyperplasia, Botulinum neurotoxin, Detrusor overactivity, Detrusor – sphincter dyssynergia, Interstitial cystitis, Voiding dysfunction, Chronic pelvic pain,

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