Ali Rıza TÜRKOĞLU, Yasemin BUDAK, Soner ÇOBAN, Muhammet GÜZELSOY, Murat ÖZTÜRK, Atilla SATİR, Hakan DEMİRCİ, Kağan HUYSAL

The Hemoglobin-Red Cell Distribution Width and Neutrophil -Lymphocyte Ratio in Predicting Lamina Propria Invasion in Bladder Tumors?

Objective: To investigate the impor-tance of the Hemoglobin/Red cell distribu-tion width ratio (Hb/RDW) and Neutrophil/ Lymphocyte ratio (NLR) in predicting bladder lamina propria invasion before transurethral resection in non-muscular invasive bladder cancer (NMIBC) patients Meterial and Methods: The data of the patients whose pathology after transurethral resection of the bladder was NMIBC between January 2010 and June 2016 were evaluated retrospectively. Group 1 had Ta (mucosa in-volvement) and Group 2 had T1 (submucosa involvement) lesions. The age, gender, tumor size and number of tumors of the patients were identified. The preoperative blood leu-cocyte (WBC), hemoglobin (Hb), neutrophil (N), lymphocyte (L), monocyte (M), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW) values were identified and the NLR, PLR, LMR values cal-culated. The Hb/RDW ratio was determined. Results: A total of 369 patients were evaluated. The mean age was similar between groups. Group 1 (Ta) consisted of 219 patients (66.3±10.7 years) and Group 2 (T1) 150 pa-tients (66.9±10.4 years) (p=0.638). NLR was higher in Group 2 than Group 1 (2.4 (1.5) and 2.2 (1.5), respectively, p=0.042) and this difference was statistically significant. The Hb/RDW ratio in Group 2 was lower than in Group 1 (0.89±21 and 0.94±19, respectively, p=0.019) and this difference was statistically significant. Conclusion: We believe that a decrease in the Hb/RDW ratio and increase in NLR, which can be easily determined from the pe-ripheral blood in the preoperative period, can be associated with lamina propria invasion (T1). These studies should be supported with prospective large series

Amaç: Non-musculer invazive bladder cancer (NMIBC) hastalarında Hemoglobin-Red cell Distrubition Width oranı (Hb/RDW) ve Nötrofil/Lenfosit oranının (NLR) mesane-nin transüretral rezeksiyonu öncesi lamina propria invazyonunu önğörmede önemini araştırmak. Gereç ve Yöntemler: Ocak 2010- Hazi-ran 2016 yılları arası mesanenin transüretral rezeksiyonu sonrası patolojisi NMIBC olan hastaların verileri retrospektif değerlendirildi. Hastalar Grup 1: Ta (mukoza tutulumu), Grup 2: T1 (submukoza tutulumu) olarak 2 gruba ayrıldılar. Hastaların yaşları, cinsiyetleri, tü-mör boyutu ve tümör sayıları belirlendi. Preo-peratif tam kan değerlerinden lökosit (WBC), hemoglobin (Hb), nötrofil (N), lenfosit (L), monosit (M), platelet (PLT), mean platelet volümü (MPV), Red cell Distrubition Width (RDW) değerleri belirlendikten sonra NLR, PLR, LMR değerleri hesaplandı. Hb/RDW oranı belirlendi. Bulgular: Patolojik evresi NMIBC olan 369 hasta değerlendirildi. Gruplar arasın-da yaş farkı yoktu. Grup 1 (Ta); 219 hasta, 66.3±10.7 yıl olup grup 2 (T1); 150 hasta, 66.9±10.4 yıl oldu (p=0.638). NLR grup 2’de grup 1’den yüksek olup (sırasıyla 2.4 (1.5), 2.2 (1.5) ve p=0.042 ) istatistiksel olarak bu yükseklik anlamlıdır. Gruplar arasında Hb ve RDW oranları bakımından farklılık iz-lenmemesine rağmen Hb/RDW oranı grup 2’de grup 1’den düşüktür (sırasıyla 0.89±21, 0.94±19 ve p=0.019) ve istatistiksel olarak bu azalma anlamlıdır. Sonuç: Preoperatif dönemde periferik kandan kolay yolla elde edilebilen Hb/RDW oranında azalma ve NLR yükselmenin lamina propria invazyonu (T1) ile ilişkili olabileceğini düşünmekteyiz. Bu çalışmaların prospektif geniş serili çalışmalarla desteklenmesi ge-rekir.

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