Sacit Nuri GÖRGEL, Yusuf Kürşad ÖZDAMAR, Cengiz KARA, Kutan ÖZER

Prostat biyopsisinde prostat kanseri saptanan olgularda perinöral invazyonun Gleason skoru ve pozitif kor yüzdesi ile ilişkisi

Amaç: Bu çalışmada prostat spesifisik antijen PSA yüksekliği ve anormal rektal muayene nedeniyle transrektal ultrason TRUSG eşliğinde prostat biyopsisi alınan patolojisi prostat adenokarsinomu olarak raporlanan olgulardaki perinöral invazyonun PNI , gleason skoru ve pozitif kor yüzdesi ile ilişkisini araştırdık.Gereç ve Yöntem: Kliniğimizde 2004-2011 yılları arasında PSA yüksekliği ve anormal rektal muayene bulgusu nedeniyle TRUSG eşliğinde 10 kadran prostat biyopsisi alınan 1135 olgudan 274’ünde % 24.14 prostat adenokarsinomu saptandı. Prostat adenokarsinomu saptanan olguların 46’sında % 16.78 perinöral invazyon gözlendi. Perinöral invazyonu olan ve olmayan olgular yaş, total PSA, prostat volümü, PSA dansitesi, gleason skoru, pozitif kor yüzdesi, rektal muayene açısından karşılaştırıldı. Bunun yanı sıra olgular toplam gleason skoru ≤6 ve >6 ve pozitif kor yüzdesi ≤ % 33 ve > % 33 olmak üzere iki gruba ayrıldı ve perinöral invazyon açısından karşılaştırıldı.Bulgular: Gleason skoru ≤6 olan grupta yaş ortalaması 69.60 ± 6.56 iken gleason skoru >6 olan grupta yaş ortalaması 70.68 ± 8.34 idi p=0.153 . Gleason skoru ≤6 olan grupta ortalama PSA değeri 12.10 ± 4.57 mg/dl iken gleason skoru >6 olan grupta ortalama PSA değeri 13.11 ± 4.53 idi p=0.652 . Tüm olgularda sintigrafide kemik metastazı saptanma oranı % 31.25 iken bu oran gleason skoru ≤6 olan grupta % 6.6, gleason skoru > 6 olan grupta ise % 46.6idi. p6 olan hastalarda kemik sintigrafisinde saptanan metastaz oranı anlamlı derecede yüksekti p

Anahtar Kelimeler:

Prostat biyopsisi, Perinöral invazyon, Gleason skoru

Relationship between the positive core percentage and Gleason score with perineural invasion in patient with prostate cancer on prostate biopsy

Objective: In this study, we investigated relationship between the positive core percentage and gleason score with perineural invasion PNI in patients who underwent transrectal ultrasonography TRUSG guided prostate biopsy because of high prostate specific antigen PSA values and abnormal digital rectal examination.Materials and Methods: A total of 1135 patients underwent 10-quadrant TRUSG guide prostate biopsy because of high PSA values and abnormal digital rectal examination in our clinic between 2004-2011. Prostate adenocarcinoma was detected in 274 patients 24.14% . Perineural invasion was demonstrated in 46 16.78% of prostate carcinoma cases. Cases with and without PNI were compared in terms of age, total PSA, prostate volume, PSA density, gleason score, positive core percentage and rectal examination. Patients were divided into 2 groups of total gleason score ≤6 and total gleason score >6, also positive core percentages were divided into 2 groups ≤33% and > 33% and these groups were compared in terms of perineural invasion.Results: The mean age was 69.60 ± 6.56 in patients with gleason score ≤6 and 70.68 ± 8.34 in patients with gleason score > 6 p=0.153 . The mean PSA level was 12.10 ± 4.57 mg/ dl in patients with gleason score ≤ 6 and 13.11 ± 4.53 in patients with gleason score >6 p=0.652 . The rate of metastasis on bone scintigraphy was 31.25% in total, 6.6% in with gleason score ≤ 6 and 46.6% in patients with gleason score >6 p6 p

Keywords:

Prostate biopsy, Perineural invasion, Gleason score,

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