Sacit Nuri GÖRGEL, Yusuf Kürşad ÖZDAMAR, Uğur BALCI

Gleason skoru 3+4 ve 4+3 prostat kanseri olgularında preoperatif klinikopatolojik ve radyografik bulguların karşılaştırılması

Amaç: Bu çalışmada prostat spesifik antijen PSA yüksekliği ve anormal rektal muayene bulgusu nedeniyle transrektal ultrasonografi TRUSG eşliğinde prostat biyopsisi alınan olgularda, biyopsi spesmenindeki gleason skoru 3+4 olan olgularla, 4+3 olan olguların preoperatif klinikopatolojik ve radyografik bulgularını karşılaştırmayı amaçladık. Gereç ve Yöntem: Kliniğimizde 2004-2011 yılları arasında PSA yüksekliği ve anormal rektal muayene bulgusu nedeniyle TRUSG eşliğinde 10 kadran prostat biyopsisi alınan 1135 olgudan, patolojisi prostat adenokarsinomu olarak raporlanan ve gleason skoru 3+4 olan 56 hasta Grup 1 ile gleason skoru 4+3 olan 48 hasta Grup 2 çalışmaya dahil edildi. Her iki gruptaki olgular yaş, total PSA, PSA dansitesi, ortalama prostat volümü, pozitif kor yüzdesi, pozitif kor yüzdesinin ≥ %33 olması, pozitif korlardaki en yüksek tümör yüzdesinin ortalaması, perinöral invazyon, rektal muayene ve tomografik bulgular açısından karşılaştırıldı. Bulgular: Grup 1 ve Grup 2’deki olgular karşılaştırıldığında yaş, ortalama prostat volümü, total PSA, PSA dansitesi, pozitif kor yüzdesi, pozitif kor yüzdesinin ≥ %33 olması, perinöral invazyon, rektal muayene ve tomografik bulgular açısından fark saptanmadı. Pozitif korlardaki en yüksek tümör yüzdesinin ortalaması Grup 1’de %69.60 ± 25.31 ve Grup 2’de %86.55 ±17.68 olarak bulundu ve gleason skoru 4+3 olan grupta istatistiksel olarak anlamlı oranda yüksekti p

Anahtar Kelimeler:

Prostat kanseri, Prostat biyopsisi, Gleason Skoru

Comparison of preoperative clinicopathological and radiographical findings between prostate cancer cases with gleason score 3+4 and 4+3

Objective: In this study, our objective was to compare the preoperative clinicopathological and radiographical findings of prostate cancer cases with gleason score 3+4 and 4+3 diagnosed by transrectal ultrasonography TRUSG guided biopsy. Materials and Methods: A total of 1135 patients underwent 10-quadrant TRUSG guide prostate biopsy because of high PSA values or abnormal digital rectal examination in our clinic between 2004-2011. Of those patients who had adenocarcinoma were divided into 2 groups of Gleason score 3+4 Group 1, 56 patients and Gleason score 4+3 Group 2, 48 patients . These two groups were compared in terms of age, total PSA, PSA density, mean prostate size, positive core percentage, a positive core value of 33% or more, mean highest positive core tumor percentage, perineural invasion, rectal examination and tomography findings. Results: Both groups are compared clinical, pathological and in terms of tomographical findings preoperatively. In this comparison, there was no difference in terms of age, total PSA, PSA density; mean prostate volume, positive core percentage, a positive core value of 33% or more, perineural invasion, rectal examination and tomography findings. The mean highest positive core tumor percentage was %69.60 ± 25.31 in group 1 and %86.55 ±17.68 in group 2. The mean highest positive core tumor percentage was significantly higher in the group 2 p

Keywords:

Prostate cancer, Prostate biopsy, Gleason score,

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