Mustafa GÜRKAN YENİCE, MURAT TUNCER, Kubilay SABUNCU, Selçuk ŞAHİN, Volkan TUĞCU, Kemal SARICA, Ali İhsan TAŞÇI

Obstruktif uyku apne sendromu ve erektil disfonksiyon

Amaç: Tekrarlayan üst solunum yolu kollapsı ile karakterize olan Obstruktif Uyku Apne Sendromu OSAS , 40’lı yaşlarını geçmiş erkeklerin %10’undan fazlasında gösterilmiş olup bu erkeklerin %30 ile 50’sinde sebebi tam açıklanamamış erektil disfonksiyon görülmektedir. Bu çalışmamızda etiyolojisi netlik kazanmamış multifaktöryel nedenlere bağlı olduğu düşünülen OSAS ve ED ilişkisi ortaya konulmaya çalışılmıştır. Gereç ve Yöntem: Uyku bozukluğu nedeniyle Kulak Burun Boğaz hastalıkları obstruktif uyku apne bozukluğu polikliniğine başvurusu sonrası polisomnografik testleri yapılan , erektil disfonksiyon nedeniyle tedavi olamamış 70 hastanın demografik bilgileri, gonadal fonksiyonları, alt üriner sistem semptom sorguları, komorbidite indeksleri ve IIEF International Index of Erectile Function -15 sorgu formları eşliğinde erektil disfonksiyon açısından sorgulanmıştır. Bulgular: Polisomnografik bulgularına göre obstruktif sleep apne derecesi sınıflandırılan hastalar gruplandırılarak IIEF-15 formu ve belirtilen parametreler çerçevesinde değerlendirildiğinde uyku apne sendromu ile erektil disfonksiyon arasında anlamlı ilişki olduğu saptandı p

Anahtar Kelimeler:

Uyku, Apne, Erektil Disfonksiyon

Obstructive sleep apnea syndrome and erectile dysfunction

Objective: Obstructive Sleep Apnea Syndrome OSAS , which characterized recurrent upper respiratory tract collapse, is shown over 40 years old men in more than 10% incidence, which cause erectile dysfunction that not clearly defined, in 30% with 50% of these men have OSAS. In this study we have tried to reveal the relationship OSAS and ED because of unclear multifactorial etiology. Material and Methods: We have examined 70 patients who could not be treated because of erectile dysfunction; demographic information, gonadal function, lower urinary tract symptoms, comorbidity index and IIEF International Index of Erectile Function -15 form for erectile dysfunction, who applied for sleep disturbance and testing polisomnograpy at polisomnograpy laboratuary. Results: The polysomnographic findings by obstructive sleep apnea degree of patients classified by grouping IIEF-15 form and evaluated within the framework specified parameters with sleep apnea syndrome were found to have significant association between erectile dysfunction p

Keywords:

Sleep, Apnea, Erectile Dysfunction,

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Kochar MS, Mazur LI, Patel A et al. (1999) What is causing your patient’s sexual dysfunction? Uncovering a connection with hypertension and antihypertensive therapy. Postgrad Med 106:149–152, 155–147.
Hirshkowitz M, Karacan I, Arcasoy MO et al. Prevalen- ce of sleep apnea in men with erectile dysfunction. Uro- logy 1990;36:232-4.
Young T. Pepard PE, Gottlied DJ et al. Epidemyology of obs- tructive sleep apne; a population health perspective, Am J Respir Crit, CarecMed 2002;165:1217-39.
Pressman, M.R. et al Problems in the interpretation of noc- turnal penile tumescence studies: disruption of sleep by oc- cult sleep disorders. J Urol 1986;136:595.
Fanfulla F, Malaguti S, Montagna T et al. Erectile dysfunc- tion in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep 2000; 23: 775–81.
Margel D, Cohen M, Livne PM et al. but not mild, obstructi- ve sleep apnea syndrome is associated with erectile dysfunc- tion. Urology 2004; 63: 545–9.
Guilleminault C, Eldridge FL, Tilkian A et al. Sleep apnea syndrome due to upper airway obstruction. A review of 25 cases. Arch Intern Med 1977; 137: 296–300.
Feldman HA, Johannes CB, Derby CA et al. Erectile dysfunction and coronary risk factors, prospective re- sults from the Massachusetts male aging study. Prev Med 2000;30: 328–338.
Fanfulla F, Malaguti S, Montagna T et al. Erectile dysfunc- tion in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep 2000; 23: 775–81.
Ip MS, Lam B, Chan LY et al. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by na- sal continuous positive airway pressure.
McKenna KE. Neural circuitry involved in sexual function. J Spinal Cord Med 2001;24:148-54.
Soukhova-O Hare GK, Shah ZA, Lei Z et al. Erectile dysfunction in a murine model of sleep apnea. Am J Respir Crit Care Med 2008; 178:644-50.
Roizenblatt S, Guilleminault C, Poyars D et al. A dub- le blind, placebo controlled, crossover study of silde- nafil in obstructive sleep apnea. Arc intern Med 2006 166:1763-1767.14-Kennedy SH, Rizvi S et al. Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 2009;29:157-64.