Karyotipik bozukluk gösteren intratestiküler leyomiyom
İntratestiküler leyomiyom benign karakterli ve nadir görülen bir skrotal kitle sebebidir. Preoperatif klinik bulgular ile malign bir testiküler kitleden ayrımı mümkün olmamaktadır. Bu durum benign karakterdeki bir tümör nedeniyle testis kaybına yol açmaktadır. Klinik olarak malign-benign ayrımı yapılamayan şüpheli durumlarda peroperatif yapılacak frozen inceleme ile doğru tanı ve tedavi yapılabilir. Erkeklerde düz kas dokusu kaynaklı benign tümörlerde karyotipik anormallik görülmesi son derece ender bildirilen bir durumdur. Leyomiyom patogenezinin altında yatan moleküler mekanizmaların henüz anlaşılamamış olması saptanan karyotipik anomalilerin önemini arttırmaktadır
Intratesticular leiomyoma with abnormal karyotype
Intratesticular leiomyoma is a benign and rarely observed cause of scrotal mass. It can not be distinguished from a malign testicular mass by using preoperative clinical findings. This may cause the loss of testis because of a benign tumour. In uncertain cases which malign-benign decision can not be made clinically, the correct diagnosis and treatment can be achieved using peroperatively frozen section procedure. Karyotype anomalies in -smooth muscle originated benign tumours- in males is a very rarely observed. The fact that the molecular mechanisms of the leiomioma pathogenesis have not been understood yet, is increasing the importance of karyotype anomalies observed
___
- Ellimoottil C, Perz S, Mehta V, Turk TM, Wheeler J. Solid testicular mass in a 63-year-old man. Urology 2013;81:9- 11.
- Giyanani VL, Hennigan DB, Fowler M, Sanders TJ. Sonog- raphic findings in leiomyoma of postorchiectomy scrotum. Urology 1985;25:204-6.
- Gorunova L, Bjerkehagen B, Heim S. Paratesticular lei- omyoma with a der(14)t(12;14)(q15;q24). Cancer Genet 2011;204:465-8.
- Park SB, Lee WC, Kim JK, Choi SH, Kang BS, Moon KH, et al. Imaging features of benign solid testicular and parates- ticular lesions. European Radiol 2011;21:2226-34.
- Mak CW, Tzeng WS, Chou CK, Chen CY, Chang JM, Tzeng CC. Leiomyoma arising from the tunica albugi- nea of the testis: sonographic findings. J Clin Ultrasound 2004;32:309-11.
- Bremmer F, Kessel FJ, Behnes CL, Trojan L, Heinrich E. Leiomyoma of the tunica albuginea, a case report of a rare tumour of the testis and review of the literature. Diagn Pat- hol. 2012;7:140.
- Kim W, Rosen MA, Langer JE, Banner MP, Siegelman ES, Ramchandani P. US MR imaging correlation in pathologic conditions of the scrotum. Radiographics 2007;27:1239- 53.
- Akbar SA, Sayyed TA, Jafri SZ, Hasteh F, Neill JS. Multi- modality imaging of paratesticular neoplasms and their rare mimics. Radiographics 2003;23:1461-76.
- Heidenreich A. A case of an intratesticular leyomyoma. J Ultrasound Med 1999;18:614.
- Canda AE, Atmaca AF, Ozdemir AT, Akbulut Z, Balbay MD. Testis sparing surgery for sequential bilateral testicu- lar tumors. Can J Urol 2009;16:4677-81.
- Kirkali Z, Tüzel E, Canda AE, Mungan MU. Testis sparing surgery for the treatment of a sequential bilateral testicular germ cell tumor. Int J Urol 2001 ;8:710-2.
- Tuygun C, Ozturk U, Goktug HN, Zengin K, Sener NC, Bakirtas H. Evaluation of frozen section results in patients who have suspected testicular masses: a preliminary re- port. Urol J 2014;11:1253-7.