DENİZ ANUK İNCE, Ece YAPAKÇI, Aylin TARCAN

Hipokalsemi ile giden subkutan yağ nekrozu olan bir vaka

Subkutan yağ nekrozu yaşamın ilk haftalarında nadir görülen, adipoz dokunun inflamatuvar hastalığıdır. Lezyonlar yüz, boyun, proksimal ekstremite, sırtta subkutan nodül veya plaklar şeklinde gözlenmektedir. Patofizyolojisi tam olarak bilinmemektedir. Subkutan yağ nekrozunun seyrinde sıklıkla hiperkalsemi tanımlanmış olup, hipokalsemi ile birlikteliği nadir görülmektedir. Hastamızda hipokalsemi-nin nedeninin polistemi, asfiksi olabileceği, bu nedenle subkutan yağ nekrozunun neden değil, eşlik eden bir bulgu olduğu düşünülmüştür.

Anahtar Kelimeler:

Yağ nekrozu, Hipokalsemi, Süt çocuğu, yenidoğan, Kadın

Subcutaneous fat necrosis with hypocalcaemia in a newborn

Subcutaneous fat necrosis is an inflammatory disorder of the adipose tissue, which appears during the first weeks of life. The skin lesions are usually located on the face, trunk, proximal extremities and back which present as subcutaneous nodules and plaques. The pathogenesis of subcutaneous fat necrosis is still unknown. The cutaneous involvement is often associated with hypercalcemia, but hypocalcemia is rarely reported with subcutaneous fat necrosis. Hypocalcemia might be secondary to perinatal hypoxia and polycytemia in neonatal period, therefore we think that hypocalcemia with subcutaneous fat necrosis is coincidental in this case.

Keywords:

Fat Necrosis, Hypocalcemia, Infant, Newborn, Female,

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1. Karochristou K, Siahanidou T, Kakorou-Tsivitanidou T, Stefanaki K, Mandyla H. Subcutaneous fat necrosis associated with severe hypocalcaemia in a neonate. Journal of Perinatology 2006;26: 64-6.
2. Tran J, Sheth A. Complications of subcutaneous fat necrosis of the newborn: a case report and review of the literature. Pediatric Dermatology 2003;20: 257-61.
3. Rice A, Rivkees S. Etidronate therapy for hypercalcemia in subcutaneous fat necrosis of the newborn. Journal of Pediatrics 1999;134: 349-51.
4. Balfour E, Antaya R, Lazova R. Subcutaneous fat necrosis of the newborn presenting as a large plaque with lobulated cystic areas. Continuing Medical Education 2002;70: 169-74.
5. Dudink J, Walther FJ, Beekman RP. Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification. Arch Dis Child Fetal Neonatal Ed 2003;88: 343-5.
6. Borgia F, Pasquale L, Cacace C, Meo P, Guarneri C, Cannavo S. Subcutaneous fat necrosis of the newborn: Be aware of hypercalcaemia. Journal of Paediatrics and Child Health 2006;42: 316-8.