Kedilerde İntranasal ve İntramusküler Zolazepam-Tiletamine Kombinasyonu Uygulamasının Karşılaştırılması
Bu
çalışmanın amacı kedilerde zolazepam-tiletamine (ZT) kombinasyonunun
intramusküler (IM) ve intranasal (IN) uygulamasını karşılaştırmaktı.
Ağırlıkları 2.47 ± 0.6 kg olan 8 sağlıklı erişkin kedi kullanıldı. Her kediye 10 mg/kg ZT
kombinasyonunu uygulamalar arasında en az birer hafta ara olacak şekilde IN ve
IM yol ile verildi. Sedasyon başlangıcı, cerrahi anestezi süresi ve uyanma
zamanı kaydedildi. Parametreler ZT kombinasyonundan hemen önce ve uygulama
sonrasındaki 5, 10, 15, 20 ve 30. dakikalarda kaydedildi. Her iki uygulama
yolunda, herhangi bir anestezik komplikasyon görülmedi. Tüm hayvanlarda uyanma
problemsiz gerçekleşti. Anestezi süresi ve sedasyon başlangıcı değerleri, IN ve
IM uygulamaya bağlı istatistiksel farklılık göstermedi. ZT kombinasyonu IN
yolla verildiğinde (30.63 ± 0.32 dakika) IM enjeksiyona (33.38 ± 0.32 min) göre
istatistiksel olarak daha kısa sürede uyanma gerçekleşti. ZT kombinasyonun
uygulama yolunun, kalp frekansı (P =
0.388), solunum sayısı (P = 0.628),
rektal sıcaklık (P = 0.066) ve
peripheral hemoglobin oksijen saturasyonu (P
= 0.442) değerleri üzerine etkisi yoktu. ZT kombinasyonunun intranasal
uygulanması kedilerde sedasyon için alternatif bir teknik olabilir.
Anahtar Kelimeler:
Anestezi, Intranasal, Intramusküler, Kedi, Tiletamine, Zolazepam
Comparison of Intranasal and Intramuscular Administration of Zolazepam-Tiletamine Combination in Cats
The purpose of the current study was to compare intranasal (IN) and
intramuscular (IM) administration of zolazepam-tiletamine (ZT) combination in
cats. Eight adult healthy cats weighing 2.47 ± 0.6 kg were used. Each animal received 10 mg/kg ZT
combination by IN and IM routes with a minimum one week intervals. The onset of
sedation, the length of surgical anaesthesia and the recovery time were
recorded. The parameters were recorded
immediately before and at 5, 10, 15, 20, and 30 min after administration of ZT
combination. No anaesthetic complication was observed in either
administration route. Recovery was uneventful in all animals. There were no
statistical differences between the IN and IM administration with respect to
onset of sedation and the length of anaesthesia. Recovery time was
significantly shorter when the ZT combination was administered IN route (30.63
± 0.32 min) compared to IM injection (33.38 ± 0.32 min). The route of
administration of the ZT combination had no effect on heart rate (P = 0.388), respiratory rate (P = 0.628), rectal temperature (P = 0.066), and peripheral haemoglobin
oxygen saturation (P = 0.442).
Intranasal administration of ZT combination can be an alternative technique for
sedation in cats.
Keywords:
Anaesthesia, Cat, Intramuscular, Intranasal, Tiletamine, Zolazepam,
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- Başlangıç: 2022
- Yayıncı: Atatürk Üniversitesi