Volkan KOŞAL, Ömer Faruk KELEŞ, Ahmet Ufuk KÖMÜROĞLU, Yıldıray BASBUGAN

Geriatrik (3 Yaşlı) Erkek Ratlarda Üreme Parametrelerinin Araştırılması

Yaşlanmaya bağlı olarak pek çok sağlık sorunu görülmektedir. Bu sorunlardan biri de üreme sistemindeki problemlerdir. Üreme sistemi sorunlarına alt üriner sistem semptomları, prostat hastalıkları, düşük dölverimi, testis fonksiyon bozuklukları neden olur. Bu çalışmadaki amaç geriatrik (3 yaş) ve genç (3 aylık) sıçanların üreme parametrelerinin karşılaştırılması oldu. 3 yaşındaki bir rat ortalama 90-95 yaşındaki bir insana denk gelmektedir. Bu amaçla geriatrik (3 yaş) ve genç (3 aylık) ratlarda sperm analizi, testis ve prostat histopatolojisi, testiküler oksidatif stres parametreleri incelendi. Analiz sonuçlarında geriatric grupta sperm motilite oranının düştüğü (p<0.001), anormal sperm oranının arttığı (p<0.001), sperm yoğunluğunun azaldığı (p<0.001) belirlendi. İstatistiksel olarak geriatric grupta oksidatif stress parametrelerinin MDA, AOPP, T-SH seviyelerinin arttığı (p<0.05) ve CAT seviyesinin düştüğü (p<0.05) tespit edildi. Histopatolojik olarak geriatrik grupta tubulus seminiferous contortuslarda dejenerasyon, nekroz ve düzensiz dizilimler gözlendi. Geriatik grupta prostat bezinde hiperplazi ve dilatasyon tespit edildi. Bu çalışma verileri sonucunda geriatrik erkek ratlarda üreme performansının çok düşük olduğu ve üreme olasılığının çok zor olduğu düşünülmektedir.

Anahtar Kelimeler:

Geriatri, Prostat, Rat, Sperm, Testis

Investigation of Reproductive Parameters in Male Geriatric (3 years old) Rats

Many health problems are seen due to aging. One of these is problems in the reproductive system. Reproductive system problems are caused by lower urinary system symptoms, prostate diseases, low fertility, testicular dysfunction. The aim of this study was to compare reproductive parameters of geriatric (3 years old) and young (3 months old) rats. A 3-year-old rat is equivalent to an average 90-95-year-old human. For this purpose, sperm analysis, testicular and prostate histopathology, testicular oxidative stress parameters were examined in geriatric (3 years old) and young (3 months old) rats. In the analysis results, it was determined that sperm motility ratio decreased (p<0.001), abnormal sperm ratio increased (p<0.001) and sperm density decreased (p<0.001) in the geriatric group. Statistically, oxidative stress parameters MDA, AOPP, T-SH levels increased (p<0.05) and CAT level decreased (p<0.05) in geriatric group. Histopathologically, degeneration, necrosis and irregular alignments were observed in the tubulus seminiferous contortus in the geriatric group. Hyperplasia and dilatation of the prostate gland were detected in the geriatric group. As a result of this study, it is thought that reproductive performance in geriatric male rats is very low, and the probability of reproduction is very difficult.

Keywords:

Geriatri, Prostate, Rat, Sperm, Testis.,

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