Babesiosisli Koyunlarda Çinko ve Bakır Konsantrasyonları ve Karbonik Anhidraz Enzim Aktivitesinin Saptanması

Bu çalışma, Van yöresindeki babesiosisli koyunlarda çinko, bakır konsantrasyonları, Cu/Zn oranı ve karbonik anhidraz enzim aktivitesini araştırmak amacıyla planlandı. Çalışmada, canlı materyal olarak babesiosisli 1.5–2 yaş arası toplam 36 Akkaraman koyun (hasta grup) kullanıldı. Hasta koyunlar tedavi edilerek tedavi sonrası grubu oluşturuldu. Sağlıklı 20 Akkaraman ırkı koyun ise kontrol grubu olarak ayrıldı. Vena jugularisten usulüne uygun olarak alınan kan örneklerinde; bakır ve çinko konsantrasyonları ve karbonik anhidraz enzim aktiviteleri tayin edildi. Çinko düzeyleri; hasta grupta en düşük (p

Anahtar Kelimeler:

Koyun, Babesia ovis, Bakır, Çinko, Cu/Zn oranı, Karbonik anhidraz

Babesiosisli Koyunlarda Çinko ve Bakır Konsantrasyonları ve Karbonik Anhidraz Enzim Aktivitesinin Saptanması

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Abdel-All TS (1991). Haematological and biochemical studies on the efficacy of synanthic against gastro-intestinal parasites in sheep. Assiut Vet Med J, 24(48): 197-203.
Akar Ş, Üner A (2001). Paraziter hastalıklarda eser elementlerin düzeyleri. Türk Parazitol Derg, 25(32): 86-290.
Ambawat HK, Malhotra DV, Kumar S, Dhar S (1999). Erythrocyte associated haemato-biochemical changes in Babesia equi infection experimentally produced in donkeys. Vet Parasitol, 85(4): 319– 324.
Anonim (2007). http://www.dpi.qld.gov.au/images/Biosecurity_ GeneralAnimal BabesiaBovis-Organism-250.jpg. Erişim tarihi: 15.06.2007 AndDiseases/ TickFever
Baum MK, Shor Posner G, Campa A (2000). Zinc status in human immunodeficiency virus infection. J Nutr, 130, 1421–1423.
Berg J, Tymoczko J, Stryer L (2002). Biochemistry, 5th Ed., W.H. Freeman Co.
Chaturvedi UC, Shrivastava R, Upreti RK (2004). Viral infections and trace elements: a complex interaction. Curr Sci, 87, 1536– 1554.
Costanzo L, De-Guidi G, Giuffrida S, Sortino S, Condorelli G (1995). Antioxidant effect of inorganic ions on UVC and UVB inuced lipid peroxidation. J Inorg Biochem, 59(1): 1-13.
Çimtay İ, Sevgili M (2003). Koksidiyozisli kuzularda tedavi öncesi ve sonrası bazı hematolojik ve biyokimyasal parametreler üzerine araştırmalar. YYÜ Vet Fak Derg, 4, 91-94.
Dede S, Değer Y, Değer S ve Alkan M (2000). Bazı endoparazitlerle (Fasciola sp.+Trichostrongylidae sp.+Eimeria sp.) enfekte koyunlarda lipit peroksidasyonu ve antioksidan durumunun saptanması. Türk Parazitol Derg, 24 (1): 190-193.
Dede S, Değer Y, Değer S, Tanritanir P (2008). Plasma Pevels of Zinc, Copper, Copper/Zinc Ratio, and Activity of Carbonic Anhydrase in Equine Eiroplasmosis. Biol Trace Elem Res, 25 (1): 41-45.
Değer S, Biçek K,Değer Y (2005). Theileriosisli sığırlarda bazı biyokimyasal parametrelerdeki (Demir, Bakır, Vit C, Vit E) değişiklikler. YYÜ Vet Fak Derg, 16, 49-50.
Eaton SB, and Eaton SB (2000). Consumption of Trace Elements and Minerals by Pragricultural Humans Chepter 1. in: Clinical Nutrition of the Essential Trace Elements and Minerals Ed: Bogden J.D. Klevay L.M. Humana Press, Totowa, New Jersey.
Failla ML (2003). Trace elements and host defense: recent advances and continuing challenges. J Nutr, 133, 1443–1447.
Greenberg WE, Trusell RR, Clescer LS (1996). Standart Methods for the Examination of Water and Wastewater, 60ht ed. American Public Health Association, Washington.
Healy J, Tipton K (2007). Ceruloplasmin and what it might do. J Neurol Transm, 114(6): 777–781.
Karakaş Z, Demirel N, Tarakcioglu M, Mete N (2001). Serum zinc and copper levels in southeastern Turkish children with Giardiasis or amebiasis. Biol Trace Elem Res, 84 (1-3): 143-146.
Koçyiğit A, Gür S, Erel O, Gürel MS (2002). Associations among plasma selenium, zinc, copper, and iron concentrations and immunoregulatory cytokine levels in patients with cutaneous leishmaniasis. Biol Trace Elem Res, 90 (1): 2-3.
Kozat S,Yüksek N,Altuğ N,Ağaoğlu ZT,Erçin F (2003). Studies on the effect of iron preparations in addition to babesiosis treatment on the haematological and some mineral levels in sheep naturally infected with Babesia ovis. YYÜ Vet Fak Derg, 14(2): 18-21.
Leung PL, Lsi XL (1996). Multielement analysis in serum of thyroid cancer patients before and after a surgical operation. Biol Trace Elem Res, 51(3): 259–266.
Lin CC, Huang JF, Tsai LY, Huang YL (2006). Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biol Trace Elem Res, 109, 15–24.
Lindskog S (1997). Structure and mechanism of carbonic anhydrase. Pharmacol Ther, 74, 1-20.
Longbottom JE, Martin TD, Edgell KW, Long SE, Plantz MR, Warden BE (1994). Determination of trace elements in water by inductively coupled plasma-mass spectrometry, collaborative study. J AOAC Int, 77 (4): 1004-1023.
Lukaski HC (2004). Vitamin and mineral status: effects on physical performance. Nutrition, 20 (7–8): 615– 619.
Mafra M, Cozzolino SMF (2004). Erythrocyte Zinc and Carbonic Anhydrase Levels in Nondialyzed Chronic Kidney Disease Patients. Clin Biochem, 37, 67-71.
Maren TA (1960). A simplified micromethod for the determination of carbonic anhydrase and 1+5 inhibitors. J Pharmacol Exp Ther, 72, 77–87.
Matousek AJ, Burguera JL, Burguera M, Añez N (1993). Changes in the total content of iron, copper, and zinc in serum, heart, liver, spleen, and skeletal muscle tissues of rats infected with Trypanosoma cruzi. Biol Trace Elem Res, 37(1): 110-116.
Mishra NC, Kabilan L, Sharma A (1994). Oxidative stress and malaria-infected erythiocytes. Ind J Mahrid, 31 (2): 77–87.
Mocchegiani E, Muzzioli M (2000). Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections. J Nutr, 130, 1424–1431.
Morton S, Robert D J (1993). Unicam AAS Methods, Manual Issue 2 (05/93) Universty of Bristol, UK.
Radostits OM, Blood DC, Gay CC (1995). Veterinary Medicine. Bailliere and Tindall, England.
Seyrek K, Paşa S, Kıral F, Bildik A, Babür C, Kılıç S (2004). Levels of zinc, copper and magnesium in sheep with Toxoplasmosis. Uludag Univ J Fac Vet Med, 23 (1-2-3): 39-42.
Supuran CT, Scozzafava A, Conway J (2004). Carbonic anhydrase its inhibitors and activators. CRC, Boca Raton, FL, USA.
Tanyüksel M, Sayal A, Aydın A (1995). Paraziter hastalıklarda eser elementlerin düzeyleri. Türk Parazitol Derg, 19 (2): 315-321.
Taşçı S, Sengil AZ, Altındiş M, Arısoy K (1995). The effect of zinc supplementation in experimentally induced Toxoplasma gondii infection. J Egypt Soc Parasitol, 25, 745-755.
Taşkapan Ç, Atambay M, Aycan ÖM ve ark. (2007). Giardiosisli hastalarda serum çinko (Zn) düzeyleri. Türk Parazitol Derg, 31 (1): 14-16.
Underwood EJ (1977). Trace Elements in Human and Aminal Nutrition, 4th ed Academic Press , New York.
Van Weyenbergh J, Santana G, D'Oliveira A et al. (2004). Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study. BMC Infect Dis, 17, 50.
Voyvoda H, Sekin S, Kaya A, Bildik A (1997). Koyunların Doğal Babesia konsantrasyonu (Fe,Cu), Total ve latent demir bağlama kapasitesi (TDBK, LDBK) ve transferin doyumu (TD) modifikasyonları. Tr J Vet Anim Sci, 21(3): 31-37. serum demir, bakır
Wellinghausen N, Jöchle W, Reuter S, Flegel WA, Grünert A, Kern P (1999). Zinc status in patients with alveolar echinococcosis is related to disease progression. Parasite Immunol, 21(5): 237–241.
Wirth JJ, Fraker PJ, Kierszenbaum F (1989). Zinc requirement for macrophage function: effect of zinc deficiency on uptake and killing of protozoan parasite. Immunology,68, 114-119.
Yörük I, Deger Y, Mert H, Mert N (2007). Serum concentration of copper, zinc, iron and cobalt and the copper/zinc ratio in horses with equine herpesvirus-1. Biol Trace Elem Res, 118 (1): 38–42.