Propofol

Bu makalede, son yıllarda kısa etkili intravenöz anestezik olarak yaygın bir şekilde kullanılan propofolun özellikleri, farmakokinetiği, etkileri ve yapılan son klinik çalışmalar hakkında bilgi verilmiştir

Anahtar Kelimeler:

Propofol, Anestezi indüksiyonu

Propofol

In this article on propofol, its properties, pharmacokinetics, effects, adverse reactions and recent data obtained from clinical trials were reviewed

Keywords:

Propofol, Induction of anaesthesia.,

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Sear JW: Continuous of hypnotic agents for maintenance of anaesthesia. Ed. B Kay : Total Intravenous Anaesthesia. 21th ed. (Elsevier, Ireland), p.40, (1991).
Glen JB, Hıınter SC: Pharmacology of an emulsion formulation of ICI 35868, Br J Anaesth 56: 617-625, (1984).
Duke T: A new intravenous anesthetic agent: propofol, Can Vet J 36: 181-183, (1995).
Kanto J, Gepts E: Pharmacokinetic implications for the clinical use of propofol, Clin Phaımacokinet 17: 308-326, (1989).
Simons PJ, Cockshott ID, Douglas EJ, et al : Species diffeıences in blood profıles, metabolism and excrection of 14C- propofol, Xenobiotica 21:1243-1256, (1991).
Mandsager RE, Clarke CR, Shawley RV, Hague CM: Effects of chloramfenicol on infusion pharmacokinetics of propofol in greyhounds, Am J Vet Res 56: 95-99, (1995).
Reid J Nolan AM, Welsh E: Propofol as an indııction agent in the goat: a pharmacokinetic study, J Vet Pharmacol Therap 16: 488- 493, (1993).
Cockshott ID, Douglas EJ, Plummer GF. Simons PJ: The pharmacokinetics of propofol in laboratory animals, Xenobiotica 22: 369-375, (1993).
Morgan DJ, Campbell GA, Crankshaw DP: Pharmacokinetics of propofol when given by intravenous infusion, Br J Clin Pharmac 30: 144-148, (1990).
Campbell GA, Morgan DJ, Kumar K, Crankshaw DP: Extended blood collection period required to define distribution and elimination kinetics of propofol, Br J Clin Pharmac 26: 187-190, (1988).
Kiıkpatrick T, Cockshott ID, Douglas EJ, Nimma WS: Pharmacokinetics of propofol (diprivan) in elderly patiens, Br J Anaesth 60: 146-150,(1988).
Reid J, Nolan AM: Pharmocokinetics of propofol as an induction agent in geriatric dogs, Res Vet Sci 61: 169-171, (1988).
Dailland P, Cockshott ID, Lirzin JD, et al: intravenous propofol duıing cesarean section : placental transfer, concentıations in breast milk, and neonatal effects. A preliminary study, Anesthesiology 71: 827-834, (1989).
Bayhan N, Güzeldemir ME, Önder S: Küçük cerrahi girişimlerde anestezi indüksiyonunda ve idamesinde propofol. Türk Anest Reanim Cem Mec 17(S 1): 202-205, (1989).
Bayhan N, Güzeldemir ME, Önder S, Dağlı G: Küçük cerrahi girişimlerde anestezi indüksiyonu ve idamesinde propofol ve etomidatın karşılaştırmalı olarak incelenmesi, Türk Anest Rean Cem Mec 18: 91-94, (1990).
Şentürk Y, Tanrıverdi B, Tomatır E, Bağcılar İ: Propofol ile kısa süreli anestezinin indüksiyonu ve idamesi, Türk Anest Rean Cem Mec 17(S 1): 206-210, (1989).
Sebel PS, Lowdon JD: Propofol: a new intravenous anesthetic, Anesthesiology 71: 260-277, (1989).
Oikkonen M: Anaesthesia for geriatric oesophagoscopy: isofluıane vs, alfentani-methohexitone vs, propofol. Açta Anaesthesiol Scand 36: 195-200, (1992).
Sun S, Köse Y, Özkoca S, ve ark : Propofol ile indüksiyon, Türk Anest Rean Cem Mec 17(S 1): 199-201, (1989).
Keçik Y, Tüziiner F, Bulucu P, Yörükoğlu D: İndıiksiyonda tiyopenton ve propofolun göziçi basıncına etkileri, Türk Anest Rean Cem Mec 17(S 1): 241-243, (1989).
Ramazanoğlu A, Ertok E, Yücel İ, ve ark: Propoflun göziçi basıncı ve kardiyovasküler sistem üzerine olan etkilerinin tiyopenton ile karşılaştırılması, Türk Anest Rean Cem Mec 17(S1): 236-240,(1989).
Langley MS, Heel RC: Propofol : a review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthetic, Drugs 35: 334-372, (1988).
Morgan DWT, Legge K: Clinical evaluation of propofol as an intravenous anaesthetic in cats and dogs, Vet Rec 14: 31-33, (1989).
Weaver BMQ, Raptopoulos D: Induction of anaesthesia in dogs and cats with propofol, Vet Rec 23: 617-620, (1990).
Portella LV, Natalini CC, Toledo EC, et al: Cardiovascular and respiratory effects of anaesthesia with propofol in cats previously treated with xylazine/ketamine. Ciencia Ruıal 26: 223-227 (Vet Bull 1998; 68 : Abstr No 561), (1996).
Canpolat İ, Karabulut E, Günay C: Köpeklerde propofol ile anestezi, F Ü Sağl Bil Derg 11: 333-336, (1997).
Thurman C, Ko JCH, Benson GJ, et al : Hemodynamic and analgesic effects of propofol infusion in medetomidine- premedicated dogs, Am Vet Res 55: 363-367, (1994).
Thurman C, Tranquilli WJ, Ko JCH, et al: Clinical appraisal of propofol as an anesthetic in dogs premedicated with medetomidine, Canine Pract 20: 21-25, (1995).
Hellebrekers LJ, Sap R: Medetomidine as a premedicant for ketamine, propofol or fentanyl anaesthesia in dogs, Vet Rec 140: 545-548, (1997).
Keegan RD, Green SA: Cardiovascular effects of continuous two-hour propofol infusion in dogs comparison with isoflurane anesthesia, Vet Surgery 22: 537-543, (1993).
Funkquist PME, Nyman GC, Löfgren AMJ, et al: Use of pıopofol-isoflurane as an anesthetic regimen for cesarean section in dogs, JAVMA 211: 313-317, (1997).
Lin HC, Purohit RC, Powe TA: Anesthesia in sheep with propofol or with xylazine-ketamine followed by halothane, Vet Surgery 26: 247-252,(1997).
Mather LE, Selby DG, Runciman WB: Pharmacology of propofol, Anaest Intens Çare 15: 112-113, (1987).
Gaynor JS, Wertz EM, Alvis M, Tumer AS: A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes, J Vet Pharmacol Therap 21: 69-73, (1998).
Mama KR, Steffey EP, Pascoe PJ: Evaluation of propofol as a general anaesthetic for horses, Vet Surgery 24: 188-194, 0995).
Matthevvs NS, Chaffın MK, Erickson SW, Overhulse WA: Propofol anesthesia for non-surgical procedures of neonatal foals, Equine Pract 17: 15-20, (1995).
Flaherty D, Reid J, Welsh E, et al: A pharmacodynamic study of propofol or ketamine infusions in ponies undergoing surgery, Res VetSci 62: 179-184,(1997).
Lüders C, Ahumada F, Baroni E, et al: Pharmacokinetic study of propofol in horses, Vet Bull 68: 1442, Abstr No 8998, (1998).
Duke T, Egger CM. Ferguson JG, Frketic MM: Cardiopulmonary effects of propofol infusions in llamas, Am J Vet Res 58: 153- 156,(1997).
Lukasik VM, Gentz EJ, Erb HN, et al: Cardiopulmonary effects of propofol anesthesia in chickens (Gallus gallus domesticus), J Avian Med Surgery 11: 93-97, (1997).
Ceren G : Tavuklarda Propofol Anestezisi, (Yüksek Lisans Tezi), YYÜ Sağl Bil Enst (savunulmamış tez sonuçları).
Schumacher J, Citino SB, Hemandez K, et al: Cardiopulmonary and anesthetic effects of propofol in wild tuıkeys, Am J Vet Res 58: 1014-1017, (1997).
Mama KR, Phillips LG, Pascoe P: Use of propofol for induction and maintenance of anesthesia in a bam owl (Tyto alba) undergoing tracheal resection, J Zoo Wildlife Med 27: 397- 401,(1996).
Tüzüner F, Keçik Y, Bilgin S, Özdemir Ş: Anestezi indüksiyonu ve devamlılığında propofol, Türk Anest Rean Cem Mec 17(S1): 211-213,(1989).
Altan A, Yaşar F, Gürpınar î: Çocuklarda propofol ve tiopentonun indiiksiyon ajanı olarak karşılaştırılması, Türk Anest Rean Cem Mec 17(S 1); 222-225, (1989).
Muir WW, Gadawski JE: Respiratory depression and apnea induced by propofol in dogs, Am J Vet Res 59: 157-161, (1998).
Bufalari A, Miller SM, Giannoni C, Short CE: The use of propofol as an induction agent for halothane and isoflurane anesthesia in dogs, J Am Anim Hosp Assoc 34: 84-91, (1998).