Ayşe Ceylan HAMAMCIOĞLU, Zehra SAFİ ÖZ, Taner BAYRAKTAROĞLU

Yeni Tanı Almış Tip 2 Diabetes Mellitus Hastalarında Plazma E Vitamini ve Plazma Nitrit/Nitrat Anyon Düzeylerinin Değerlendirilmesi

Amaç: Oksidatif stres, tip 2 Diabetes mellitus (T2DM) başlangıcını indükler. Hem plazma E vitamini (EV) hem de nitrit/nitrat anyon (NOx) seviyeleri, farklı mekanizmalar yoluyla diyabetin neden olduğu endotelyal hasarı belirlemek için çok önemli faktörler olabilir. Bu nedenle bu çalışmada yeni tanı almış T2DM hastalarının plazma EV ve NOx konsantrasyonlarını değerlendirmeyi ve hastaların lipid profilleri ile herhangi bir korelasyon olup olmadığını anlamayı amaçladık. Gereç ve Yöntemler: Hastalar (n=15) ve kontroller (n=15) üniversitemiz diyabet polikliniğine sağlık muayenesi için ilk geldiklerinde kan örnekleri alındı ve plazma EV ve NOx düzeylerinin saptanması için kullanıldı. Hasta dosyaları hem demografik verileri hem de biyokimyasal parametreleri kaydetmek için değerlendirildi. Veriler Kolmogorov-Smirnov testine göre normal dağıldı. Bu nedenle hasta ve kontrol verilerinin karşılaştırılmasında Student t testi ve korelasyon analizi için Pearson testi uygulandı. Bulgular: Yeni tanı konmuş T2DM hastalarında total kolesterol (TK) ve trigliserit düzeyleri anlamlı olarak yükselirken (sırasıyla p=0,036 ve p

Anahtar Kelimeler:

E vitamini, nitritler, nitratlar, kolesterol, diabetes mellitus;tip 2

The Evaluation of Plasma Vitamin E and Plasma Nitrite/Nitrate Anion Levels in Newly Diagnosed Type 2 Diabetes Mellitus Patients

Aim: Oxidative stress induces the onset of type 2 Diabetes mellitus (T2DM). Both plasma vitamin E (VE) and nitrite/nitrate anion (NOx) levels might be crucial factors to determine diabetes induced endothelial damage through different mechanisms. Therefore, in this study, we aimed to evaluate plasma VE and NOx concentrations of newly diagnosed T2DM patients and to understand whether any correlation exists with the patients’ lipid profiles. Material and Methods: Blood samples were taken when the patients (n=15) and the controls (n=15) first came to our university’s diabetes policlinic for investigation and were used to detect plasma VE and NOx levels. Patients’ files were evaluated to record both the demographic data and biochemical parameters. The data was distributed normally according to Kolmogorov-Smirnov test. Therefore, Student t test was chosen to compare patient and control data and Pearson test was applied for correlation analysis. Results: In newly diagnosed T2DM patients, total cholesterol (TC) and triglyceride levels were found to be significantly elevated (p=0.036, and p

Keywords:

vitamin E, nitrites, nitrates, cholesterol, diabetes mellitus;type 2,

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