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Tip 1 Diyabetes Mellituslu Hastalarda 25 - Hidroksi Vitamin D Düzeyi ve Metabolik Kontrol Arasındaki İlişki

Amaç: Diyabetes Mellitus, insülin sekresyonu, insülin etkisi veya her ikisindeki bozukluğa bağlı olarak gelişen kan şekeri yüksekliği ile karakterize metabolik bozukluktur. Diyabet ilişkili komplikasyonlardan korunmak için metabolik kontrol takibi glikolize hemoglobin A1C ile yapılmaktadır. 25-hidroksi vitamin D steroid yapıda bir hormon olup pankreasta insülin salgılanmasında etkili olduğu bilinmektedir. Bu çalışma Tip 1 diyabetli çocuklarda D vitamini eksikliği sıklığının ve metabolik kontrol ile ilişkisini araştırmak amacıyla yapılmıştır.Gereç ve Yöntemler: Bu retrospektif çalışmada, tip 1 diyabetli 109 çocuk değerlendirildi. Serum 25-hidroksivitamin D, hemoglobin A1C, tiroid fonksiyon testleri, kalsiyum, fosfor, magnezyum, parathormon ve alkalen fosfataz düzeyleri ölçüldü. Hastalar vitamin D düzeyine göre eksik, yetersiz veya normal olarak 3 gruba ayrıldı.Bulgular: Serum 25(OH)D düzeyleri, hastaların%31.8’inde eksik veya yetersiz saptandı. 25(OH)D düzeyi< 20 ng / mL olan hasta grubunda parathormon ve alkalen fosfataz düzeyleri 25(OH)D düzeyi≥ 20 ng / mL olan gruba göre yüksek (p

The Relationship Between 25 - Hydroxy Vitamin D Level and Metabolic Control in Type 1 Diabetes Mellitus Patients

Objective: Diabetes Mellitus is a metabolic disorder characterized by elevated blood sugar due to impairment of insulinsecretion, insulin effect, or both. Metabolic control is performed with glycolated hemoglobin A1C to protect againstdiabetes-related complications. 25-hydroxy vitamin D is a steroid hormone that is known to be effective in pancreaticinsulin secretion. This study was conducted to investigate frequency of vitamin D deficiency and relationship effect of itson metabolic control in children with type 1 diabetes. Material and Methods: In this retrospective study, 109 children with type 1 diabetes were evaluated. Serum25-hydroxyvitamin D, hemoglobin A1C, thyroid function tests, calcium, phosphorus, magnesium, parathormone, andalkaline phosphatase levels were measured. Patients were divided into 3 groups according to their vitamin D level. Results: Serum 25(OH)D levels revealed vitamin D deficiency or insufficiency in 31.8% of the patients. Higherparathormone, and alkaline phosphatase levels were found in the patient group whose mean 25(OH)D level was 20 ng/mL (p0.05). Conclusion: Although we could not show a significant association between vitamin D deficiency and 25(OH)D and itsmetabolites and the metabolic control in patients with chronic diseases such as type 1 diabetes, we consider that systemiceffects should be considered routinely.

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