Selim DERECİ, Fatih DURAN, Salim NESELİOGLU, Burcu HIDIMOGLU, Duygu İSKENDER MAZMAN, Aysel ÜNLÜSOY AKSU, Arzu Meltem DEMİR, Özcan EREL, Samil HİZLİ

Pediatrik Ülseratif Kolit Hastalarında Antioksidan Native Tiyol Düzeyinin İnflmatauvar Markırlar ve Hastalık Aktivite İndeksi ile İlişkisi

Amaç: Pediatrik ülseratif kolit (PÜK) inflamatuar bir hastalıktır. PÜK patogenezinde oksidatif stres oluşturan antioksidan aktivite ile reaktif oksijen türleri arasındaki dengesizlik ile ilişkilidir. Native tiyol (NT) seviyesi, iltihaplanma ve antioksidan seviyesinin pratik ve tekrarlanabilir belirteci olan antioksidan kapasitedir. NT düzeyinin inflamatuar belirteçler ve pediatrik ülseratif kolit aktivite indeksi (PÜKAI) ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya 38 PÜK hastası (ÇG) ve 33 kontrol grubu (KG) katılımcısı dahil edildi. PÜK hastaları, PUKAI’ye göre hastalık aktivitesi remisyonda, hafif, orta ve şiddetli olarak gruplandı. Tüm katılımcıların NT, hemoglobin (Hb), beyaz kan hücresi (WBC), trombosit (PLT), ortalama trombosit hacmi (MPV), albümin, C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESH), interlökin 6 (IL-6) seviyeleri ölçüldü ve kaydedildi. Bulgular: Grupların ortalama yaş ve cinsiyet oranları benzerdi (p>0.050). ÇG’nin NT düzeyi, KG’ye göre istatistiksel olarak yüksek (p=0.001). ÇG’nin Hb, PLT, MPV, CRP, ESR, IL-6 düzeyleri istatistiksel olarak KG’den farklıydı (p=0.045, p=0.026, p=0.001, p=0.001, p=0.001, p=0.001). ÇG’nin NT düzeyi Hb, MPV, albümin ile pozitif korelasyon gösterdi (p=0.001). ÇG’nin NT düzeyi PLT, CRP, ESR, IL-6 ve PUCAI ile negatif korelasyon gösterdi (p=0.001). Sonuç: PÜK hastalarında NT seviyesi, KG’den anlamlı olarak düşük bulundu. ÇG’nin NT düzeyi PÜK hastalarında iyi bir prognostik faktör olan albümin ile pozitif korelasyon gösterdi. NT ölçümü PÜK yönetimi için tekrarlanabilir, noninvaziv bir serum biyobelirteç olabilir.

Anahtar Kelimeler:

Aktivite, Antioksidan, Çocuk, Native tiyol, Ülseratif kolit

Relation of Antioxidant Native Thiol Level with Inflammatory Markers and Disease Activity Index in Pediatric Ulcerative Colitis

Objective: Pediatric ulcerative colitis (PUC) is an inflammatory disease. PUC pathogenesis is associated with an imbalance between reactive oxygen species and antioxidant activity which creates oxidative stress. Native thiol (NT) level is antioxidant capacity which is practical and repeatable marker of inflammation and antioxidan level. We aimed to analyse the relation of NT level with inflammatory markers and pediatric ulcerative colitis activity index (PUCAI). Material and Methods: Thirty-eight PUC patients (SG) and 33 control group (CG) participants were included in the study. PUC patients grouped as in remission, mild, moderate and severe activity according to disease activity according to PUCAI. NT, hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV), albumin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6) levels of all participants were measured at the time they were enrolled in the study and recorded. Results: Mean age and gender ratio of groups were similar (p>0.050). NT level of SG statistically high compared to CG (p=0.001). Hb, PLT, MPV, CRP, ESR, IL-6 levels of SG were statistically different than CG (p=0.045, p=0.026, p=0.001, p=0.001, p=0.001, p=0.001). NT level of SG was positively correlated with Hb, MPV, albumin (p=0.001, for all). NT level of SG was negatively correlated with PLT, CRP, ESR, IL-6 and PUCAI (p=0.001). Conclusion: NT level of PUC is significantly lower than CG. NT level of SG was positively correlated with albumin which is a good prognostic factor in PUC patients. NT may be repeatable, noninvasive candidate serum biomarker for PUC management.

Keywords:

Activity, Antioxidant, Children, Thiol, Ulcerative colitis,

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