Suna EMİR, Saime ERGEN, Bahri KEYİK, Elif GÜLER, Gülşen KÖSE

Germ Hücreli Tümörü Olan Bir Çocukta Moyamoya Hastalığı

Moyamoya hastalığı (MMH) internal karotid arterler ve proksimal dallarının ilerleyici stenozuyla birlikte hastalarda felçlere zemin hazırlayan serebrovasküler bir durumdur. Moyamoya hastalığı çeşitli doğumsal ve edinsel bozukluklar ile ilişkili olarak tarif edilmiştir. Konjenital hematolojik bozukluklar (Fanconi anemisi, orak hücreli anemi), genetik sendromlar (apert sendromu, Seckel sendromu, Robinow sendromu, Down sendromu, nörofibromatosiz tip 1), homosistinüri gibi metabolik bozukluklar Moyamoya hastalığı ile ilişkili olarak bilinmektedir. Aynı zamanda sella/kiazma bölgesi tümörlerinde ve lösemi nedeniyle profilaktik radyoterapi alan hastalarda MMH geliştiği bilinmektedir. Şimdiye dek MMH ile over tümörü arasında bir ilişki tanımlanmamıştır. Burada, tekrarlayan over tümörü olan, kurtarma kemoterapisi sonrası MMH gelişen 8 yaşında bir kız vaka bildirilmiştir.

Anahtar Kelimeler:

Kanser, Germ hücreli tumor, Moyamoya hastalığı, Over tümörü, Vaskülopati

Moyamoya Disease in a Child with Germ Cell Tumor

Moyamoya disease (MMD) is a cerebrovascular condition that predisposes affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches. Moyamoya disease has been described in association with a variety of congenital and acquired diseases. Some congenital hematological diseases (Fanconi anemia, sickle cell anemia), genetic syndromes (Apert’s syndrome, Seckel syndrome, Robinow syndrome, Down syndrome, neurofibromatosis type I), metabolic diseases (homocystinuria) are known to associated with Moyamoya syndrome. It is also known that MMD may develop after cranial radiotherapy in children with sella/chiasma region tumors or after prophylactic cranial irradiation for leukemia. However, there is no data regarding the presence of an association between ovarian tumor and MMD. Here, we report a case of an 8-year-old girl with recurrent ovarian tumor developed MMD after salvage chemotherapy

Keywords:

Cancer, Germ cell tumor, Moyamoya disease, Ovarian tumor, Vasculopathy,

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