Mehmet Fatih ORHAN, İpek BULUT KAPLAN, Nida DİNÇEL, Kadriye ÖZDEMİR, Betül SÖZEREİ, Sevgi MİR, Mustafa Orhan BULUT

Böbrek Nakli Olan Çocuklarda Aneminin Sıklığı ve Risk Faktörleri

Amaç: Renal transplantlı hastaların takibinde anemi yaygın görülmektedir. Renal transplantlı çocuklarda görülen anemi hakkında yeterli bilgi bulunmamaktadır.Bu çalışmanın amacı; transplantasyon sonrası çocuklarda kısa ve uzun dönemde ortaya çıkan aneminin risk faktörlerini ve prevalansını değerlendirmektir.Gereç ve Yöntemler: Bu çalışma, Ege Üniversitesi’ndeki böbrek nakilli çocuklarda yapılmıştır. Hematokrit düzeyinin yaşa göre 2 standart deviasyon altında olması anemi olarak tanımlanmıştır.Bulgular: Erken post transplant dönemde anemi insidansı %18 bulundu. Geç post transplant dönemde ortalama olarak 60 ayda %27.5 oranda anemi saptandı. Anemi insidansı post transplant 24.36,48 ve 60. aylarda sırasıyla %18.4, %23.3, %23 ve %27.5 bulundu. Takip süresince herhangi bir zamanda 71 (%67.6) hastada en az bir kez anemi tespit edildi. Transplantasyon sonrası herhangi bir dönemde kullanılan ACE inhibitörü ile anemi arasında ilişki saptanmadı. Donör tipi ve yaşı ile geç anemi arasında anlamlı bir ilişki bulunmadı. Diğer yandan, geç dönem anemi rejeksiyon öyküsüyle anlamlı ilişkili bulundu.Sonuç: Renal transplant alıcısı olan çocuklarda tahmini glomerül filtrasyon hızının düşüklüğü, transplantasyon sonrası sürenin uzunluğu ve rejeksiyon atağı anemi için risk faktörleridir.

Anahtar Kelimeler:

Anemi, Çocuk, Renal transplantasyon

The Prevalence and Risk Factors of Anemia in Children with Renal he Prevalence and Risk Factors of Anemia in Children with Renal Transplant

Objective: Anemia is commonly observed during the follow-ups of patients with renal transplantation. There is not enough information on anemia observed in children with renal transplantation. The aim of this study was to evaluate the prevalence and risk factors of anemia in children with renal transplantation on the short and long-term posttransplantation period.Material and Methods: This study was performed in children who underwent renal transplant at Ege University. Anemia was defi ned as having a value less than 2 Standard Deviation for hematocrit levels according to age.Results: In the early post-transplant period, the incidence of anemia was found as 18%. Late post transplant anemia rate was detected as 27.5% at 60 months. The incidence of anemia was 18.4%, 23.3%, 23% and 27.5%, at 24, 36, 48 and 60 months after transplantation, respectively. Anemia was detected at least once in 71 (67.6%) patients at any point of the follow-up period. There was no correlation between Angiotensin Converting Enzyme inhibitor therapy and anemia at any post-transplant time. Donor type and donor age were not signifi cantly associated with late anemia. On the other hand, late anemia was signifi cantly associated with a history of rejection. Conclusion: Low estimated Glomerular Filtration Rate, longer duration of post-transplantation and rejection attacks are the risk factors for anemia in pediatric renal transplant recipients

Keywords:

Anemia, Children, Renal transplantation,

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