Pınar Atasayar TABANLI, Bahar Çuhaci ÇAKIR, Ceyda Tuna KIRSAÇLIOĞLU, İhsan ESEN

Benign Geçici Hiperfosfatazemili Bir Olgu Sunumu

Benign geçici hiperfosfatazemi (BGH) 5 yaşın altında, karaciğer ya da kemik hastalığına dair herhangi bir bulgusu olmayan çocuklarda, serum alkalen fosfataz (ALP) düzeylerinin yükselmesi ve 12-16 hafta içinde kendiliğinden normal düzeylere inmesidir. Bu yazıda rutin muayene sırasında tetkik edilirken, ALP yüksekliği saptanan, karaciğer ve kemik hastalığı bulgusu olmayan ve izleminin 6. haftasında ALP düzeyleri normale dönen, 11 aylık bir kız olgu sunulmuştur.

Anahtar Kelimeler:

Alkalen fosfataz, Çocuk

Benign Transient Hyperphosphatasemia in an Infant

Benign Transient Hyperphosphatasemia (BTH) is an elevation in serum alkaline phosphatase (ALP) level under 5 years of age without any symptoms of liver or bone disease and a return to normal levels within 12-16 weeks. Herein, an 11-month-old girl with no evidence of liver or bone disease, having elevated serum ALP level that was noticed on a routine examination and returned to normal levels after 6 weeks of follow-up has been presented

Keywords:

Alkaline phosphatase, Child,

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Huh SY, Feldman HA, Cox JE, Gordon CM. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009;124:703-9.
Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: A prospective cohort. J Pediatr Endocrinol Metab 2011;24:93-5.
Balcı YI, Işık P, Türk M, Polat Y, Erbil N. Selim geçici hiperfosfatazemili bir cocuk. Yeni Tıp Dergisi 2008;25:239-40.
Turan S, Topcu B, Gökçe İ, Güran T, Atay Z, Omar A, et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol 2011;3:7-11.
Arikan C, Arslan MT, Kilic M, Aydogdu S. Transient hyperp- hosphatasemia after pediatric liver transplantation. Pediatr Int 2006;48:390-2.
Eboriadou M, Skouli G, Panagopoulou P, Haidopoulou K, Makedou A, Varlamis G. Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: A new case of transient hyperphosphatasemia in early childhood. J Paediatr Child Health 2006;42:149-50.
Tolaymat N, de Melo MC. Benign transient hyperphosphatasemia of infancy and childhood. South Med J 2000;93:1162-4.
Suzuki M, Okazaki T, Nagai T, Törõ K, Sétonyi P. Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002;33:215-8.
Crofton PM. What is the cause of benign transient hyperphospha- tasemia? A study of 35 cases. Clin Chem 1988;34:335-40.
Fawaz R, Israel E. Transient hyperphosphatasemia of infancy and early childhood. http://www.uptodate.com This topic last updated: Nisan 22, 2010.
Eymann A, Cacchiarelli N, Alonso G, Llera J. Benign transient hyperphosphatasemia of infancy. A common benign scenario, a big concern for a pediatrician. J Pediatr Endocrinol Metab 2010;23:927-30.
Dunn V, Condon VR, Rallison ML. Familial hyperphosphatasemia: Diagnosis in early infancy and response to human thyrocalcitonin therapy. AJR Am J Roentgenol 1979;132:541-5.